Hepatic carotenoid uptake in rainbow trout (Oncorhynchus mykiss) using an isolated organ perfusion model

Page, G.I.; Davies, Steffan

doi:10.1016/s0044-8486(03)00305-3

Cited by 17 publications

(12 citation statements)

References 21 publications

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“…() studied the bioavailabilities of 14 C‐keto‐carotenoids in rainbow trout and proved that the maximum blood concentration of 14 C‐astaxanthin was greater than 14 C‐canthaxanthin. The extent of hepatic carotenoid uptake and metabolism was also indirectly investigated in rainbow trout using an in vitro isolated perfused liver model (Page & Davies ). Piscine serum perfusion showed that the cumulative uptake mechanism for both astaxanthin and canthaxanthin was saturable in the carrier models, with astaxanthin uptake saturated relatively faster than for canthaxanthin.…”

Section: Pharmacokinetics Of Astaxanthinmentioning

confidence: 99%

“…A previous investigation by Guillou et al (1992) found comparatively higher absorption rates of astaxanthin than canthaxanthin and zeaxanthin in mature female rainbow trout force-fed radiolabelled carotenoids. Accordingly, Choubert et al (2005) studied the bioavailabilities of 14 C-keto-carotenoids in rainbow trout and proved that the maximum blood concentration of 14 C-astaxanthin was greater than trout using an in vitro isolated perfused liver model (Page & Davies 2003). Piscine serum perfusion showed that the cumulative uptake mechanism for both astaxanthin and canthaxanthin was saturable in the carrier models, with astaxanthin uptake saturated relatively faster than for canthaxanthin.…”

Section: Metabolic Aspects Of Astaxanthinmentioning

confidence: 99%

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Astaxanthin as feed supplement in aquatic animals

Lim

Yusoff

Shariff

et al. 2017

Reviews in Aquaculture

307

208

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Astaxanthin is a high value keto‐carotenoid pigment renowned for its commercial application in various industries comprising aquaculture, food, cosmetic, nutraceutical and pharmaceutical. Among the verified bio‐resources of astaxanthin are red yeast Phaffia rhodozyma and green alga Haematococcus pluvialis. The supreme antioxidant property of astaxanthin reveals its tremendous potential to offer manifold health benefits among aquatic animals which is a key driving factor triggering the upsurge in global demand for the pigment. Numerous scientific researches devoted over a number of years have persistently demonstrated the instrumental role of astaxanthin in targeting several animal health conditions. This review article evaluates the current best available evidence to judge the beneficial usage of astaxanthin in aquaculture industry. Most apparent is the profound effect on pigmentation, where astaxanthin is frequently utilized as an additive in formulated diets to boost and improve the coloration of many aquatic animal species, and subsequently product quality and price. Moreover, the wide range of other physiological benefits that this biological pigment confers to these animals is also presented which include various improvements in survival, growth performance, reproductive capacity, stress tolerance, disease resistance and immune‐related gene expression.

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Section: Pharmacokinetics Of Astaxanthinmentioning

confidence: 99%

Section: Metabolic Aspects Of Astaxanthinmentioning

confidence: 99%

Astaxanthin as feed supplement in aquatic animals

Lim

Yusoff

Shariff

et al. 2017

Reviews in Aquaculture

307

208

View full text Add to dashboard Cite

show abstract

“…This is in agreement with the findings of Hardy et al . (1990) and Page and Davies (2003) in rainbow trout and Torrissen and Ingebrigtsen (1992) in Atlantic salmon. On the other hand, urinary elimination of 14 C‐canthaxanthin and 14 C‐astaxanthin in fish appeared as a very minor pathway in rainbow trout in comparison with biliary elimination.…”

Section: Discussionmentioning

confidence: 97%

Pharmacokinetics and bioavailabilities of 14C-keto-carotenoids, astaxanthin and canthaxanthin, in rainbow trout, Oncorhynchus mykiss

Choubert

Cravedi²,

Laurentie³

2005

Aquac Research

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The pharmacokinetics and bioavailabilities of 14 C-astaxanthin and 14 C-canthaxanthin were studied in the blood of rainbow trout following intra-arterial (i.a.) and oral (p.o.) administration. Sixteen months old 1 kg trout were cannulated in the dorsal aorta.[6,7,6 0 ,7 0 -14 C]-keto-carotenoids were administered i.a. and p.o. at a dose of 573.5 kBq kg À1 ¢sh body weight for astaxanthin and 836.2 kBq kg À1 ¢sh body weight for canthaxanthin. After i.a. distribution, total body clearance (Cl tot ) was 17.30 AE 20.29 mL kg À1 of ¢sh h À1 for 14 C-canthaxanthin and 3.30 AE 1.50 mL kg À1 of ¢sh h À1 for 14 C-astaxanthin. The volume of distribution at steady-state (V ss ) was 208.32 AE 124.79 mL kg À1 of ¢sh and 71.84 AE 64.15 mL kg À1 of ¢sh for 14 C-canthaxanthin and 14 C-astaxanthin respectively. Less than 0.4% of the administered radioactivity was recovered in urine. Radioactivity (expressed as percent of the dose) excreted in the bile of ¢sh that received 14 C-canthaxanthin by i.a. route was 20-fold higher than that observed for ¢sh treated p.o. This ratio was lower for 14 C-astaxanthin (7.6-fold). The mean keto-carotenoid bioavailabilities calculated were 10^15% for both compounds. Findings suggest one daily astaxanthin application is preferable, while12-h time intervals between applications are preferable for canthaxanthin.

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“…Diets enriched with synthetic astaxanthin (Carophyll® pink 10%, DSM-Bright Science, Brighter Living™, Netherlands) and β-carotene (β-carotene 10% CWS, Direct Food Ingredients, UK) were weighed, dissolved in water at 35°C, and added to the diet according to each tested level (Page & Davies, 2003). All diets were prepared with fish oil and water and processed in a California Pelleting Machine (CPM), producing pellets at a size of 2x3 mm in diameter.…”

Section: Diet Treatmentsmentioning

confidence: 99%

Effects of dietary astaxanthin and β carotene on gonadosomatic and hepatosomatic indices, gonad and liver composition in goldfish Carassius auratus (Linnaeus, 1758) broodstocks

Tizkar

Soudagar

Bahmani³

et al. 2016

lajar

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This study investigated the effects of two source carotenoids on the hepatosomatic index (HSI) and the gonadosomatic index (GSI) of the goldfish (Carassius auratus). For this experiment, six diets containing concentrations of 50, 100, and 150 mg carotenoid kg-1 of synthetic astaxanthin and β-carotene were added to a basic carp diet, while one group of fish was fed a control diet (no added carotenoids). Fiberglass tanks were used for the study, which was performed from January to April of 2013. During the breeding period, the hepatosomatic (HSI) and gonadosomatic (GSI) indices were examined monthly, along with the total carotenoid levels in the ovaries and livers of female goldfish broodstock. A significant positive correlation was observed between total carotenoids in both the liver and ovary tissues and GSI after 90 and 120 days of the experiment. The HSI was not affected by the carotenoid-enriched diets. However, the carotenoid-enriched diets resulted in greater accumulation of carotenoids in the gonads. β-carotene-enriched diets (B150) led to greater accumulation of carotenoids in the liver after 90 days. Lastly, we found that diets containing higher levels of astaxanthin and β-carotene improve the GSI in goldfish broodstock. Efecto de la astaxantina y β-caroteno en la dieta, sobre los índices gonadosomático y hepatosomático, composición de la gónada e hígado en reproductores de carpa dorada Carassius auratus (Linnaeus, 1758) RESUMEN. Este estudio investiga el efecto de dos fuentes de carotenoides sobre el índice hepatosomático (HSI) y el índice gonadosomático (GSI) de la carpa dorada (Carassius auratus). En este experimento, se adicionaron seis dietas conteniendo concentraciones de 50, 100 y 150 mg carotenoide kg-1 de astaxantina sintética y β-caroteno a una dieta de carpa, mientras a otro grupo de peces se le suministró una dieta control (sin carotenoides). Se utilizaron estanques de fibra de vidrio de enero a abril 2013. Durante el periodo experimental, el HSI y el GSI se examinaron mensualmente junto con la concentración de carotenoides totales en ovario e hígado de hembras. Una correlación positiva significativa se encontró entre el total de carotenoides aportados en la dieta y el hígado, ovario y el GSI después de 90 y 120 días de experimento. El HSI no fue afectado por las dietas enriquecidas con carotenoides. Sin embargo, las dietas con carotenoides mostraron un mayor acumulación de carotenoides en las gónadas. La dieta con β-carotenos (B150) presentó una mayor acumulación de carotenoides ____________________ Corresponding editor: Enrique Dupré 364 Latin American Journal of Aquatic Research en el hígado después de 90 días. Finalmente, se encontró que las dietas que contenían el nivel más alto de astaxantina y β-caroteno mejoraron el GSI en los reproductores de carpa dorada.

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Hepatic carotenoid uptake in rainbow trout (Oncorhynchus mykiss) using an isolated organ perfusion model

Cited by 17 publications

References 21 publications

Astaxanthin as feed supplement in aquatic animals

Astaxanthin as feed supplement in aquatic animals

Pharmacokinetics and bioavailabilities of 14C-keto-carotenoids, astaxanthin and canthaxanthin, in rainbow trout, Oncorhynchus mykiss

Effects of dietary astaxanthin and β carotene on gonadosomatic and hepatosomatic indices, gonad and liver composition in goldfish Carassius auratus (Linnaeus, 1758) broodstocks

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