Hepatic conversion of angiotensin I and the portal hypertensive response to angiotensin II in normal and regenerating liver

Abstract

AI does not induce PHR; this effect is a result of its mandatory conversion into AII by the ACE and the sequential action of AII on the AII receptor type 1 located in the hepatic periportal zone. AII induced PHR pattern changes during liver regeneration.

Elevated Levels of Circulating Angiotensin Converting Enzyme in Patients with Hepatoportal Sclerosis

“…Angiotensin I is converted into Angiotensin II by the ACE and the sequential action of Angiotensin II on the Angiotensin II receptor type 1 located in the hepatic periportal zone. Angiotensin II induced PHR pattern changes during liver regeneration [18]. Increments in circulating ACE detected in our study may affect PHR in the portal circulation in patients with HPS.…”

“…The status of RAS in liver diseases has been investigated in several previous studies. Hepatic conversion of angiotensin I and the portal hypertensive response (PHR) to angiotensin II in normal and regenerating liver has been demonstrated by Carvalho et al [18]. Angiotensin I is converted into Angiotensin II by the ACE and the sequential action of Angiotensin II on the Angiotensin II receptor type 1 located in the hepatic periportal zone.…”

“…Increments in circulating ACE detected in our study may affect PHR in the portal circulation in patients with HPS. Angiotensin-converting enzyme (ACE), an important molecule of the renin-angiotensin system (RAS) is also considered as a regulatory molecule in systemic and portal circulation in distinct disorders [17][18][19][20]. In another study [23], ACE inhibition in the liver recipient by enalapril attenuated hepatic ischemia/reperfusion damage after experimental liver transplantation.…”

“…Demonstration of the local RASs at the tissue levels [18,21,22] further implicated the importance of ACE in the pathobiology of a wide variety of diseases. The aim of this study is to assess circulating ACE concentrations in HPS.…”

“…Angiotensin-converting enzyme (ACE), an important molecule of the renin-angiotensin system (RAS) is also considered as a regulatory molecule in systemic and portal circulation in distinct disorders [17][18][19][20]. Demonstration of the local RASs at the tissue levels [18,21,22] further implicated the importance of ACE in the pathobiology of a wide variety of diseases.…”