Hepatic cryosurgery precision evaluation of ultrasonography, thermometry, and impedancemetry in a pig model

Rivoire, Michel; Voiglio, Eric J.; Kaemmerlen, P; Molina, G.; Treilleux, Isabelle; Finzy, Jacqueline; Delay, E.; Gory, Fabien

doi:10.1002/(sici)1096-9098(199604)61:4<242::aid-jso2>3.0.co;2-a

Cited by 33 publications

(11 citation statements)

References 27 publications

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“…The volume of destroyed tissue was slightly less than the frozen volume which is to be expected because the cells in the tissue temperature range of 0 to −20°C are not completely destroyed. Other less commonly used monitoring techniques of experimental interest include thermography and impedance measurements, including the recently evolving technique of electrical impedance tomography [48,113,154,170]. …”

Section: Technology-methods and Control Of Freezingmentioning

confidence: 99%

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Experimental cryosurgery investigations in vivo

2009

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Cryosurgery is the use of freezing temperatures to elicit an ablative response in a targeted tissue. This review provides a global overview of experimentation in vivo which has been the basis of advancement of this widely applied therapeutic option. The cellular and tissue-related events that underlie the mechanisms of destruction, including direct cell injury (cryolysis), vascular stasis, apoptosis and necrosis, are described and are related to the optimal methods of technique of freezing to achieve efficacious therapy. In vivo experiments with major organs, including wound healing, the putative immunological response following thawing, and the use of cryoadjunctive strategies to enhance cancer cell sensitivity to freezing, are described.

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Section: Technology-methods and Control Of Freezingmentioning

confidence: 99%

“…Experiments with freezing the canine femur have shown that osteocytes are killed at about −10°C [64]. Normal cells of the kidney, liver and prostate die at about −15 to −20°C [170,177,185,191,192]. Fibroblasts resist freezing injury.…”

Section: The Cryogenic Lesionmentioning

confidence: 99%

Experimental cryosurgery investigations in vivo

2009

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“…Necrosis is evident within two days, and three to four days after ablation the tissue damage, i.e. the cryolesion, is sharply demarcated from undamaged surrounding hepatic tissue and consists of three main zones (9,19): A central zone of necrotic tissue, an intermediate zone of regenerative and inflammatory tissue, and a peripheral zone of partly damaged cells. In the peripheral zone the temperatures during freezing range between 240˚C and 0˚C.…”

Section: The Cryolesionmentioning

confidence: 99%

“…The spatial resolution, however, is low as only single point temperature recordings are made (19,43). Bioelectric impedance measurements are invasive, difficult to use and currently not sufficiently precise as a means for monitoring liver tumour cryoablation (19,43).…”

Section: Invasive Monitoringmentioning

confidence: 99%

Cryoablation of liver tumours – a review of mechanisms, techniques and clinical outcome

Mala

2006

Minimally Invasive Therapy & Allied Technologies

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Several techniques exist for in situ destruction or ablation of liver tumours not eligible for resection. Cryoablation, i.e. the use of low temperatures to induce local tissue necrosis, was among the first of the thermal ablative techniques widely used. The procedures have typically been performed by surgeons during laparotomy, but recently minimally invasive cryoablation has been reported feasible. The present review focuses on mechanisms of tissue destruction, techniques of ablation including procedural monitoring, and clinical outcome following cryoablation of liver tumours. Plausible causes of tumour persistence at the site of ablation, i.e. local treatment failure, are discussed. Shortcomings exist in monitoring of the freezing process and may be a main cause. The evidence for the long-term outcome following liver tumour cryoablation needs to be improved. Cryoablation has been challenged by other techniques of tumour ablation such as radiofrequency ablation. Randomised trials against these modern techniques may define the role of cryoablation in the treatment of liver tumours. With improved imaging technology and patient selection, cryoablation of liver tumours may hold promise for selected patients.

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“…A period of 4 days was selected as all tissue damage induced by freezing may not be established immediately after ablation and because no major shrinkage has occurred at this time [9,10]. At this time, the cryolesion, i.e., the region of tissue damage induced by low temperatures during freezing, is fully established and will gradually be replaced by infiltration of inflammatory cells from the periphery of the lesion [10,11].…”

Section: Animal Treatmentmentioning

confidence: 99%