Hepatic Effects of Estrogen on Plasma Distribution of Small Dense Low-Density Lipoprotein and Free Radical Production in Postmenopausal Women

Nii, Shota; Shinohara, Koichi; Matsushita, Hiroshi; Noguchi, Yasuyuki; Watanabe, Kazushi; Wakatsuki, Akihiko

doi:10.5551/jat.33175

Cited by 11 publications

(6 citation statements)

References 36 publications

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“…In addition to its benefits to the cardiovascular system, estrogen also has an effect on biomarkers of vascular activity [146]. For example, a study concerning normal postmenopausal women revealed that taking estrogen for one year significantly reduced catecholamine levels, mean blood pressure, and low-density lipoprotein (LDL), while increasing nitrite and nitrate levels [147][148][149]. Other studies on the effects of estrogen on OS have shown that serum lipid peroxides decrease, and the overall antioxidant status is upregulated [150].…”

Section: Estrogen Inhibits Oxidative Stressmentioning

confidence: 99%

Protective Effects of Estrogen on Cardiovascular Disease Mediated by Oxidative Stress

Liu

Zhou

et al. 2021

Oxidative Medicine and Cellular Longevity

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Perimenopause is an important stage of female senescence. Epidemiological investigation has shown that the incidence of cardiovascular disease in premenopausal women is lower than that in men, and the incidence of cardiovascular disease in postmenopausal women is significantly higher than that in men. This phenomenon reveals that estrogen has a definite protective effect on the cardiovascular system. In the cardiovascular system, oxidative stress is considered important in the pathogenesis of atherosclerosis, myocardial dysfunction, cardiac hypertrophy, heart failure, and myocardial ischemia. From the perspective of oxidative stress, estrogen plays a regulatory role in the cardiovascular system through the estrogen receptor, providing strategies for the treatment of menopausal women with cardiovascular diseases.

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Section: Estrogen Inhibits Oxidative Stressmentioning

confidence: 99%

Protective Effects of Estrogen on Cardiovascular Disease Mediated by Oxidative Stress

Liu

Zhou

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…We previously reported that estrogen‐induced increase in plasma triglyceride may decrease the size of LDL particles that are more susceptible to oxidative modification, 10 and increase the plasma distribution of small dense LDL 11 . As estrogen directly enters the hepatic circulation when administered orally, it stimulates the hepatic synthesis of SHBG.…”

Section: Discussionmentioning

confidence: 99%

“…Previously, we also reported that oral administration of estrogen may increase plasma triglycerides but may decrease the size of low‐density lipoprotein (LDL) particles in postmenopausal women 10 . In addition, despite its antioxidant effects, oral estrogen may enhance the production of free radicals 11 …”

Section: Introductionmentioning

confidence: 99%

Effects of androgenic properties of progestin combined with ethinyl estradiol on vascular endothelial reactivity, plasma lipids and free radical production in women with endometriosis

Sakurada

Matsushita

Noguchi

et al. 2021

J of Obstet and Gynaecol

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Aim Endothelial reactivity is inhibited and oxidative stress is enhanced in women with endometriosis. Testosterone may adversely affect lipids and endothelium. We investigated the effects of androgenic properties of progestins combined with ethinyl estradiol (EE) on endothelial function, lipids and free radical production in such women. Methods Women with endometriosis were treated with 20 μg EE + 3 mg drospirenone (DRSP) or 35 μg EE + 1 mg norethisterone (NET) for 3 months. Plasma concentrations of sex hormone‐binding globulin (SHBG), lipids, copper (Cu), derivatives of reactive oxygen metabolites (d‐ROMs), biological antioxidant potential (BAP), nitrite/nitrate, endothelin‐1 and asymmetrical dimethylarginine (ADMA) were measured before and after treatment. Flow‐mediated vasodilation (FMD) of the brachial artery was measured by ultrasonography. Results DRSP group, but not NET group, significantly increased FMD and concentrations of nitrite/nitrate and small dense LDL cholesterol, while decreased endothelin‐1 concentrations. In both groups, ADMA and LDL cholesterol concentrations were significantly decreased, but triglyceride, SHBG, d‐ROMs, Cu and ceruloplasmin concentrations increased, and BAP concentrations did not change. DRSP group significantly increased HDL cholesterol concentrations, whereas NET group decreased its concentrations. Changes in triglyceride correlated positively either with changes in SHBG (r = 0.57, P < 0.001) or with small dense LDL cholesterol (r = 0.45, P = 0.005). Changes in Cu correlated positively with changes in d‐ROMs (r = 0.87, P < 0.001). Conclusion Androgenic properties of progestin may counteract EE's favorable effects on endothelial function and HDL cholesterol, while eliminating its adverse effects on increased triglyceride‐induced small dense LDL cholesterol in women with endometriosis.

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“…A review performed in 2017 showed that MHT significantly decreased LP (a) concentration ( Anagnostis et al, 2017 ). Some studies have shown that MHT negatively influences TG level ( Mercuro et al, 2003 ; Nii et al, 2016 ). However, a study conducted in 2016 indicated that TG level was lower in MHT group than that in non-MHT group ( Ki et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Menopause Hormone Therapy on Lipid Profile in Postmenopausal Women: A Systematic Review and Meta-Analysis

et al. 2022

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Importance: The incidence of dyslipidemia increases after menopause. Menopause hormone therapy (MHT) is recommended for menopause related disease. However, it is benefit for lipid profiles is inconclusive.Objective: To conduct a systematic review and meta-analysis of randomized controlled trials to evaluate the effects of MHT on lipid profile in postmenopausal women.Evidence Review: Related articles were searched on PubMed/Medline, EMBASE, Web of Science, and Cochrane Library databases from inception to December 2020. Data extraction and quality evaluation were performed independently by two reviewers. The methodological quality was assessed using the “Cochrane Risk of Bias checklist”.Results: Seventy-three eligible studies were selected. The results showed that MHT significantly decreased the levels of TC (WMD: −0.43, 95% CI: −0.53 to −0.33), LDL-C (WMD: −0.47, 95% CI: −0.55 to −0.40) and LP (a) (WMD: −49.46, 95% CI: −64.27 to −34.64) compared with placebo or no treatment. Oral MHT led to a significantly higher TG compared with transdermal MHT (WMD: 0.12, 95% CI: 0.04–0.21). The benefits of low dose MHT on TG was also concluded when comparing with conventional-dose estrogen (WMD: −0.18, 95% CI: −0.32 to −0.03). The results also showed that conventional MHT significantly decreased LDL-C (WMD: −0.35, 95% CI: −0.50 to −0.19), but increase TG (WMD: 0.42, 95%CI: 0.18–0.65) compared with tibolone. When comparing with the different MHT regimens, estrogen (E) + progesterone (P) regimen significantly increased TC (WMD: 0.15, 95% CI: 0.09 to 0.20), LDL-C (WMD: 0.12, 95% CI: 0.07–0.17) and Lp(a) (WMD: 44.58, 95% CI:28.09–61.06) compared with estrogen alone.Conclusion and Relevance: MHT plays a positive role in lipid profile in postmenopausal women, meanwhile for women with hypertriglyceridemia, low doses or transdermal MHT or tibolone would be a safer choice. Moreover, E + P regimen might blunt the benefit of estrogen on the lipid profile.Clinical Trial Registration: [https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42018092924], identifier [No. CRD42018092924].

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Hepatic Effects of Estrogen on Plasma Distribution of Small Dense Low-Density Lipoprotein and Free Radical Production in Postmenopausal Women

Cited by 11 publications

References 36 publications

Protective Effects of Estrogen on Cardiovascular Disease Mediated by Oxidative Stress

Protective Effects of Estrogen on Cardiovascular Disease Mediated by Oxidative Stress

Effects of androgenic properties of progestin combined with ethinyl estradiol on vascular endothelial reactivity, plasma lipids and free radical production in women with endometriosis

The Effects of Menopause Hormone Therapy on Lipid Profile in Postmenopausal Women: A Systematic Review and Meta-Analysis

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