Hepatic effects of tartrazine (E 102) after systemic exposure are independent of oestrogen receptor interactions in the mouse

Meyer, Stephanie K.; Probert, Philip M. E.; Lakey, Anne F.; Axon, Andrew; Leitch, Alistair C.; Williams, Faith M.; Jowsey, Paul A.; Blain, Peter G.; Kass, George E.N.; Wright, Matthew C.

doi:10.1016/j.toxlet.2017.03.024

Cited by 23 publications

(14 citation statements)

References 57 publications

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“…The food additive dye, TZ, induced oxidative stress in the liver and brain [3][4][5], altered learning and memory functions [12], and triggered neurobiochemical alterations [22] in adult rodents. In this study, we investigated the effect of perinatal exposure to TZ on the mice newborns, focusing on the behavioral alterations and oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…Given their attractive coloring properties, variable hues, stability, and low cost, approximately eight million tons of the synthetic food colorants are produced every year [2]. The azo dyes have been receiving significant consideration since these synthetic agents can pose a health risk and exert negative effects on the liver, kidney, and nervous system [3][4][5][6]. Recent reports have pointed to the ability of azo dyes to elicit oxidative stress [4,5] and pro-inflammatory effects [1].…”

Section: Introductionmentioning

confidence: 99%

“…The azo dyes have been receiving significant consideration since these synthetic agents can pose a health risk and exert negative effects on the liver, kidney, and nervous system [3][4][5][6]. Recent reports have pointed to the ability of azo dyes to elicit oxidative stress [4,5] and pro-inflammatory effects [1]. The toxic effect of azo dyes has been attributed to the aromatic amines produced from the cleavage of the aryl- N=N-aryl At days 21 and 35, six male mice from each experimental group were sacrificed, and blood and brain samples were collected.…”

Section: Introductionmentioning

confidence: 99%

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Perinatal Exposure to Tartrazine Triggers Oxidative Stress and Neurobehavioral Alterations in Mice Offspring

et al. 2020

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The use of synthetic azo dyes as coloring agents in food products has dramatically increased. This study evaluated the effect of perinatal exposure to tartrazine (TZ) on mice offspring, focusing on neurobehavioral alterations and oxidative stress. The female mice received TZ (2.5 and 5 mg/kg) via oral gavage during pregnancy and the first 15 days after birth. At days 21 and 35 after birth, male mice were sacrificed, and samples were collected for analyses. Perinatal exposure to TZ triggered tissue injury evidenced by the histological alterations and neuronal damage in the cerebrum, medulla oblongata, and cerebellum. TZ provoked lipid peroxidation and diminished cellular antioxidants in different brain regions of the newborns. In addition, TZ increased hemoglobin content, as well as erythrocytes, leukocytes, and platelets count at days 21 and 35 after birth. Both the locomotor behavior and anxiety reflex were significantly altered in mice exposed to TZ. In conclusion, perinatal exposure to TZ within an adequate daily intake range induced oxidative stress and neurobehavioral and hematological alterations in mice offspring. Therefore, consuming foods containing TZ during pregnancy and lactation warrants public awareness.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Perinatal Exposure to Tartrazine Triggers Oxidative Stress and Neurobehavioral Alterations in Mice Offspring

et al. 2020

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“…Also, a significant rise in the mean liver weight and congested blood vessels and areas of hemorrhage in the liver were not confirmed (Himri et al, 2011). Meyer et al (2017) found that initial systemic administration of tartrazine in mice resulting in a periportal recruitment of inflammatory cells, raised serum alkaline phosphatase activity and mild periportal fibrosis. Moreover, Tartrazine alone induced the colon and hepatic NF-κB activities but there was no periportal recruitment of inflammatory cells or fibrosis.…”

Section: Effect Of Food Azo Dyes On Liver Enzymes and Hepatotoxicitymentioning

confidence: 99%

Toxicological and safety assessment of tartrazine as a synthetic food additive on health biomarkers: A review

Amin¹,

Al-Shehri²

2018

Afr. J. Biotechnol.

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Recently, progressive use of synthetic food additives increase the attention paid on their benefit and toxicity in food, especially for the young. One of these additives is artificial azo dyes tartrazine. This study aimed to provide an outline of the existing evidence on the beneficial and side effect of food additive with special reference to tartrazine on different organ health. The methods include updated search for the relevant databases. The studies included a description of the types of food additives and products containing tartrazine and focused on the effect of tartrazine on liver, kidney function, lipid profile, oxidative stress biomarkers, nervous system, hyperactivity, behavior, cancer, reproductive and developmental toxicity and some bioelement levels of tartrazine. Several studies were identified and some investigated advantage and disadvantage of tartrazine. Summary of the study provides potentially harmful effects of tartrazine on liver, renal function, lipid profiles, behavior, carcinogenicity and forthcoming research recommendation are outlined. This review gives a broad evaluation of the safety and various toxicity effects of tartrazine. It can be concluded that there is a need for professional assistance for consumers regarding food safety issues. Cumulative indications have been increased, demonstrating the potential danger of tartrazine, and the possibility to avoid its consumption.

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“…Colour in the form of powder, pastes or semi fluid is added in a wide variety of food items like beverages, baking flavors, candies and other food items to improve appearance, attractiveness and taste [1,2]. These colors are able to influence or stimulate appetite, giving the consumer a quality perception [3].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Ovarian Integrity, Reproductive Hormones, and Oxidative Stress in Albino Rats Exposed to Tartrazine Azo Dye

Elekima

Horsfall

Adimefe

et al. 2020

AJBGMB

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Aim: To assess the effect of tartrazine at ADI doses on ovarian integrity (the weight and histology of the ovary), reproductive fertility hormones (luteinizing hormones (LH), follicle stimulating hormone (FSH) and prolactin (PRL)) and oxidative stress markers (glutathione peroxidase (GPX) and superoxide dismutase (SOD)) over a period of 30 and 60 days in albino rats. Study Design: A total of 63 female rats weighing approximately 0.2kg were divided into two phases. In phase 1 (30 days treatment period), the rats were divided into 2 groups - designated tartrazine treated group (TTG1) consisting of 20 rats and control untreated group (CUG1) consisting of 15 rats. In phase 2 (60 days treatment period), the rats were again divided into 2 groups – tartrazine treated group (TTG2) consisting of 16 rats and control untreated group (CUG2) consisting of 12 rats. The acceptable daily intake (ADI) of 7.5mg/kg of the dye was administered orally while the control groups were given food and water only. Methodology: At the end of the study, the animals were anaesthetized and 5 mL of whole blood samples was collected by means of cardiac puncture into plain bottles, later spun at 4000 rpm for 5 minutes to obtain serum. The laboratory analysis of LH, FSH and PRL as well as GPX and SOD activity were based on Enzyme Linked Immunosorbent Assay (ELISA) Technique using rat-specific kits. Ovarian tissues collected were weighed using electronic balance, washed in normal saline, fixed in 10% formalin saline, embedded in paraffin wax, 5μm thick sections were obtained by rotary microtome, stained using Haematoxylin & Eosin and examined using digital Olympus microscopic. Results: Non-significant higher values in the absolute weight of the ovary (WOV), FSH, LH, and PRL while non-significant lower values in GPX and SOD were observed in the treated rats against control rats over a period of 30 and 60 days at P=.05. The histological examination over a period of 30 days did not indicate any alteration but hydropic dilation and structural alterations were seen after 60 days. Conclusion: The administration of ADI doses of tartrazine over a period of 60 days affected the integrity of the ovary mildly as observed in the histology but did not markly reflect on the biochemical markers in the plasma as well as the weight of the ovary.

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Hepatic effects of tartrazine (E 102) after systemic exposure are independent of oestrogen receptor interactions in the mouse

Cited by 23 publications

References 57 publications

Perinatal Exposure to Tartrazine Triggers Oxidative Stress and Neurobehavioral Alterations in Mice Offspring

Perinatal Exposure to Tartrazine Triggers Oxidative Stress and Neurobehavioral Alterations in Mice Offspring

Toxicological and safety assessment of tartrazine as a synthetic food additive on health biomarkers: A review

Assessment of Ovarian Integrity, Reproductive Hormones, and Oxidative Stress in Albino Rats Exposed to Tartrazine Azo Dye

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