Hepatic Inflammatory Myofibroblastic Tumor Detected in the Fetal Period That Caused an Oncologic Emergency

Abstract

A huge abdominal cystic lesion with ascites was detected in a male neonate at 31 weeks of gestation. Increasing ascites and the appearance of subcutaneous edema were detected, which caused fetal hydrops. The patient was delivered by emergency cesarean section at 33 weeks of gestation. The birth weight was 2,407 g, and the Apgar score was 8/9 points (1-/5-min values). Breathing at birth was stable, but the patient presented with remarkable abdominal distention due to the ascites. Later, the patient presented with tachypnea, and breathing gradually worsened, so an emergency operation was performed. There were no intraoperative findings within the small intestine, but there was a large amount of ascites and a cystic mass arising from the liver. The patient’s breathing and circulation dynamics could only be stabilized by ascites removal, so only a tumor biopsy was performed. The pathological findings led to the diagnosis of an inflammatory myofibroblastic tumor, and steroids were administered early after surgery for the purpose of an anti-inflammatory effect and tumor shrinkage. The abdominal distention was alleviated, and blood examinations showed a reduced inflammatory response. There was no apparent shrinkage of the tumor, however; thus, radical surgical treatment was performed on day 24. The postoperative course was uneventful, so the patient was discharged on day 36. Seven years after the operation there has been no recurrence or distant metastasis.

A Giant Solid-Cystic Gastric Inflammatory Myofibroblastic Tumor: A Case Report and Literature Review

“…Another patient had an IMT at the gastric remnant after a prior gastrectomy for an unrelated diagnosis [12]. There is a case report of H-IMT in the fetal period leading to an oncological emergency in the pregnancy [13]. The lesion has been reported in the gastric sub-mucosa in all cases and commonly in the pre-pyloric region, gastric body, and gastric antrum compared to the proximal stomach [6,[10][11][12].…”

Update on the Pathology of Pediatric Liver Tumors: A Pictorial Review

“…There is no gender predilection [61]. Occasional case reports have described an early presentation in the neonatal period [63]. The cause of IMT is unknown, although cytogenetic changes suggest that these lesions may be of clonal origin [62].…”