Hepatic inflammatory pseudotumor related with IgG4

Legkiy, Oleksandr; Wajda, Jarosław; Ćwierz, Anna; Wysocka, Joanna; Komorowski, Andrzej L.

doi:10.1016/j.gastrohep.2018.03.004

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…Research on the relationship between IMTL and IgG4 is being carried out[ 17 ]. (5) Genes: ALK is associated with IMTL, but the exact relationship between them has not been reported[ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic treatment of inflammatory myofibroblastic tumor in liver: A case report

Li¹,

Zang²,

Zhang³

2022

World J Clin Cases

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BACKGROUND Inflammatory myofibroblastic tumor in the liver (IMTL) is a rare borderline mesenchymal tumor. Neither clinical symptoms nor laboratory tests have absolute specificity for the diagnosis of IMTL, and imaging also lacks obvious specificity. Although there are sporadic reports of recurrence after surgical treatment, surgical resection is the mainstay of treatment. CASE SUMMARY A 29-year-old man complained of general weakness, slight discomfort in the upper abdomen, with a history of upper respiratory tract infection for 1 wk before admission. Plain and enhanced upper abdominal magnetic resonance imaging showed a mass in liver segments II and III (48 mm × 53 mm). He was treated by laparoscopic left lateral segmentectomy. Postoperative pathological examination with hematoxylin and eosin staining suggested that the mass in liver segments II and III was IMTL. During 21 mo postoperative follow-up, no obvious residual or recurrent lesions were observed. CONCLUSION There is a risk of malignant degeneration in IMTL. The principal choice of treatment is laparoscopic left lateral segmentectomy.

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“…Research on the relationship between IMTL and IgG4 is being carried out[ 17 ]. (5) Genes: ALK is associated with IMTL, but the exact relationship between them has not been reported[ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic treatment of inflammatory myofibroblastic tumor in liver: A case report

Li¹,

Zang²,

Zhang³

2022

World J Clin Cases

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“…Histologically, IPT of the liver is characterized by proliferation of fibrous tissue and inflammatory cells, including plasma cells, neutrophils, lymphocytes, eosinophils, macrophages, and/or multinucleated giant cells. 12 …”

Section: Discussionmentioning

confidence: 99%

Enlarging Liver Mass: Inflammatory Pseudotumor in a Patient With Polymyalgia Rheumatica

Kanagalingam

Dulymamode

Jafroodifar

et al. 2022

Journal of Investigative Medicine High Impact Case Reports

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Inflammatory pseudotumors of the liver are rare, non-neoplastic liver tumors. Due to the nonspecific clinical presentation, imaging features, and histopathological findings, they can mimic malignant tumors requiring invasive diagnostics. We present a case of a 61-year-old female patient with a history of type 2 diabetes mellitus, hypothyroidism, hyperlipidemia, and polymyalgia rheumatica who had initially presented with abdominal pain for 3 weeks. Further workup showed normal liver chemistries and tumor markers: AFP and CA 19-9. Magnetic resonance imaging (MRI) of the abdomen showed a segment 6 lesion measuring 4.1 × 4.0 × 3.7 cm. A liver biopsy then confirmed the diagnosis of an inflammatory pseudotumor of the liver with negative IgG4. On follow-up imaging, a rapid growth of this liver lesion was noted. Laparoscopy was done but did not show any distinct liver lesion. Follow-up imaging confirmed a decrease in the size of the mass. Interestingly, the patient had been on a higher dose of steroids for her polymyalgia rheumatic leading up to the follow-up imaging. This is the first case of an inflammatory pseudotumor of the liver in a patient with polymyalgia rheumatica. With this case, we would like to increase the awareness for inflammatory pseudotumors of the liver as a differential diagnosis of liver lesions in patients with underlying autoimmune disorders.

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“…Laboratory data will be notable for elevated liver enzymes in a cholestatic pattern. 9 , 10 Typically ultrasound is the first diagnostic imaging of choice which demonstrates single or multifocal hypoechoic or hyperechoic masses with increased through transmission and septation. 9 CT imaging with or without contrast notes low attenuation with several patterns of enhancement.…”

Section: Discussionmentioning

confidence: 99%

“… 9 Histopathological analysis remains the cornerstone of diagnosis demonstrating a storiform pattern, obliterative phlebitis, and mild to moderate eosinophil infiltrate with positive IgG4 plasma cells. 10 , 11 …”

Section: Discussionmentioning

confidence: 99%

Fevers, Sweats, Weight Loss, Oh My! When IgG4 Related Disease Comes Knocking. . .

Essien

Wolfley

Tate

et al. 2021

Clin Med Insights Case Rep

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Immunoglobulin G4-related systemic disease (IgG4-RSD) is a fibro-inflammatory immune condition characterized by IgG4 positive plasma cells, fibrosis, and frequently elevated serum IgG4 level. Akin to sarcoidosis, IgG4-RSD is a systemic disease with diverse organ manifestations linked by common histopathologic features. IgG4-RSD typically presents sub acutely without significant constitutional symptoms or fever. Hepatic Inflammatory pseudotumor (HIP) is a rare manifestation of IgG4-RSD composed of dense lymphoplasmacytic infiltrate and extensive fibrosis. We present an older Asian male who presented with acute onset of fever and weight loss found to have IgG4-RSD complicated by a HIP and concomitant MSSA abscess.

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Hepatic inflammatory pseudotumor related with IgG4

Cited by 5 publications

References 6 publications

Laparoscopic treatment of inflammatory myofibroblastic tumor in liver: A case report

Laparoscopic treatment of inflammatory myofibroblastic tumor in liver: A case report

Enlarging Liver Mass: Inflammatory Pseudotumor in a Patient With Polymyalgia Rheumatica

Fevers, Sweats, Weight Loss, Oh My! When IgG4 Related Disease Comes Knocking. . .

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