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Introduction.Patients with metastatic gallbladder cancer (GBC) are generally considered incurable and compelled to palliative chemotherapy. Nevertheless, there are numerous reports of successful surgical management of metastatic GBC. The impact of such treatment is yet unclear. Material and methods. We conducted a systematic literature review within Medline and Scopus databases using the following pattern: "gallbladder" and "cancer" and "dissemination". Also, our own experience with two resected metastatic GBC patients was added to the results. Discussion. The literature search yielded 8 publications with a total of hundred and twelve patients ful lling the inclusion criteria. Two additional patients were included in the analysis: one with resected GBC liver metastasis and the second with resected GBC diaphragmatic metastasis. A total of hundred and fourteen patients who underwent resection of a solid organ GBC metastasis were analyzed. The study con rmed a rare long-term survival after resection of an isolated GBC metastasis. Conclusions.There is no clear indication for surgical management of gallbladder cancer metastasis. In selected cases, an aggressive surgical approach may be justi ed. NOWOTWORY J Oncol 2019; 69, 2: 43-46

Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a rare (< 1%) primary liver cancer which contains elements of hepatocellular cancer (HCC) and bile duct cancer (CC). On account of the difficulties in reaching preoperative diagnosis, it is frequently diagnosed only after resection is performed. A surgical resection of the liver is the treatment of choice, whilst a liver transplant is a rarely implemented option. The prognosis of cHCC-CC tumours is better than in CC but worse than in HCC. This paper presents the case report of a 62-year-old man undergoing a left hemihepatectomy for a cHCC-CC liver tumour. NOWOTWORY J Oncol 2018; 68, 2: 92-94

Introduction: Skin melanoma is estimated for 2% of malignant neoplasms occurring in humans. It is characterized by a high level of malignancy and low sensitivity to cytostatic drugs. The incidence of skin melanoma increases in Poland. Lymphatic system is the most common route of dissemination of this neoplasm. The appearance of a sentinel node biopsy technique has made it possible to identify patients with a regionally advanced disease. It is a minimally invasive method with a small percentage of complications. Aim: Analysis of disease free survival (DFS) in cutaneous melanoma patients with sentinel lymph node biopsy. Material and methods: The analysis included 222 patients with cutaneous melanoma treated in the Department of Oncological Surgery in 2010–2015, who underwent a sentinel node biopsy. The study group consisted of 136 women and 86 men, the average age of patients was 59 years. Patients were qualified for sentinel node biopsy based on clinical evaluation and ultrasound of regional lymph nodes. The average follow-up was 25.1 months. About 2 hours before surgery, patients received the radioisotope, then lymphoscintigraphy SPECT was performed. Additionally, they got the Patent Blue dye in the operating room. Results: The sentinel node was identified in 217 patients (98%), and the average sentinel sentinel nodes were 2.25. 27 patients (12%) had the metastasis in sentinel nodes. In this group, the duration of asymptomatic survival was significantly shorter. Sentinel node status and age of the patient were independent factors affecting the prognosis of disease free survival. Conclusions: Sentinel node biopsy is a precise method to identify patients with skin melanoma who have metastasis to regional lymph nodes and the most important prognostic factor.