Hepatic Neoplasms from Internally Deposited 144CeCl3

Hahn, Fletcher F.; Muggenburg, Bruce A.; Boecker, B.B.

doi:10.1177/019262339602400304

Cited by 16 publications

(4 citation statements)

References 20 publications

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“…However, these estimates are likely conservative given that cancer is not typically diagnosed as soon as it reaches the threshold of clinical detection; in dogs, cancers are often diagnosed, or present for treatment, at 2.5-10 cm [61,[69][70][71][72][73][74][75][76][77][78], corresponding to 10 billion to 500 billion cells, and implying latency periods upwards of 5 years. This estimate is consistent with multi-year latency periods documented in dogs following exposure to ionizing radiation: 2-10+ years for bone malignancies [79][80][81], 2-4 years for hemangiosarcomas [67], 4-10+ years for hepatic malignancies [82], and 3-10+ years for pulmonary malignancies [83].…”

Section: Plos Onesupporting

confidence: 86%

Age at cancer diagnosis by breed, weight, sex, and cancer type in a cohort of more than 3,000 dogs: Determining the optimal age to initiate cancer screening in canine patients

Rafalko¹,

Kruglyak²,

McCleary‐Wheeler³

et al. 2023

PLoS ONE

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The goal of cancer screening is to detect disease at an early stage when treatment may be more effective. Cancer screening in dogs has relied upon annual physical examinations and routine laboratory tests, which are largely inadequate for detecting preclinical disease. With the introduction of non-invasive liquid biopsy cancer detection methods, the discussion is shifting from how to screen dogs for cancer to when to screen dogs for cancer. To address this question, we analyzed data from 3,452 cancer-diagnosed dogs to determine the age at which dogs of certain breeds and weights are typically diagnosed with cancer. In our study population, the median age at cancer diagnosis was 8.8 years, with males diagnosed at younger ages than females, and neutered dogs diagnosed at significantly later ages than intact dogs. Overall, weight was inversely correlated with age at cancer diagnosis, and purebred dogs were diagnosed at significantly younger ages than mixed-breed dogs. For breeds represented by ≥10 dogs, a breed-based median age at diagnosis was calculated. A weight-based linear regression model was developed to predict the median age at diagnosis for breeds represented by ≤10 dogs and for mixed-breed dogs. Our findings, combined with findings from previous studies which established a long duration of the preclinical phase of cancer development in dogs, suggest that it might be reasonable to consider annual cancer screening starting 2 years prior to the median age at cancer diagnosis for dogs of similar breed or weight. This logic would support a general recommendation to start cancer screening for all dogs at the age of 7, and as early as age 4 for breeds with a lower median age at cancer diagnosis, in order to increase the likelihood of early detection and treatment.

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Section: Plos Onesupporting

confidence: 86%

Age at cancer diagnosis by breed, weight, sex, and cancer type in a cohort of more than 3,000 dogs: Determining the optimal age to initiate cancer screening in canine patients

Rafalko¹,

Kruglyak²,

McCleary‐Wheeler³

et al. 2023

PLoS ONE

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show abstract

“…However, these estimates are likely conservative since cancer is not typically diagnosed as soon as it reaches the threshold of clinical detection; in dogs, cancers are often diagnosed, or present for treatment, in the range of 2.5 to 10 cm 49,62,63,74,78,83,98,105,107,108,117 (containing 10 billion to 500 billion cells), corresponding to latency periods upwards of 5 years. This estimate is consistent with multi-year latency periods previously documented in dogs following exposure to ionizing radiation: 2 to 10+ years for bone malignancies, 43,59,76 2 to 4 years for hemangiosarcomas, 116 4 to 10+ years for hepatic malignancies, 48 and 3 to 10+ years for pulmonary malignancies. 84…”

Section: Discussionsupporting

confidence: 90%

“…This estimate is consistent with multi-year latency periods previously documented in dogs following exposure to ionizing radiation: 2 to 10+ years for bone malignancies, 43,59,76 2 to 4 years for hemangiosarcomas, 116 4 to 10+ years for hepatic malignancies, 48 and 3 to 10+ years for pulmonary malignancies. 84 It is also important to note that tumor growth is not linear during the course of cancer progression.…”

Section: Discussionsupporting

confidence: 90%

Age at cancer diagnosis by breed, weight, sex, and cancer type in a cohort of over 3,000 dogs: determining the optimal age to initiate cancer screening in canine patients

Rafalko¹,

Kruglyak²,

McCleary‐Wheeler³

et al. 2022

Preprint

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The goal of cancer screening is to detect disease at an early stage when treatment may be more effective. Until recently, cancer screening in dogs has relied upon annual physical examinations and routine laboratory tests, which are largely inadequate for detecting preclinical disease. With the introduction of non-invasive liquid biopsy cancer detection methods, the discussion is shifting from How to screen dogs for cancer to When to screen dogs for cancer. To address this question, data from 3,452 cancer-diagnosed subjects were analyzed to determine the age at which dogs of certain breeds and weights are typically diagnosed with cancer. In the study population, the median age at cancer diagnosis was 8.8 years, with males diagnosed at younger ages than females, and spayed/neutered dogs diagnosed at significantly later ages than intact dogs. Overall, weight was inversely correlated with age at cancer diagnosis, and purebred dogs were diagnosed at significantly younger ages than mixed-breed dogs. For breeds with 10 or more subjects, a breed-based median age at diagnosis was calculated. A weight-based linear regression model was developed to predict the median age at diagnosis for breeds represented by fewer than 10 subjects and for mixed-breed dogs. The study findings support a general recommendation to start cancer screening for all dogs at the age of 7, and as early as 4 years of age for breeds with a lower median age at cancer diagnosis, in order to increase the chances of early detection and treatment.

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“…Commonly used induction methods are through food, drinking water, inhaled gases, or intraperitoneal or subcutaneous injection. Liver cancer can also be induced by radioactive-labeled substances like gold (Turusov 1976) or 144Ce (Hahn et al 1996).…”

Section: Induced Models Of Hccmentioning

confidence: 99%

Experimental models of hepatocellular carcinoma: developments and evolution

Tang

2009

J Cancer Res Clin Oncol

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Hepatocellular carcinoma (HCC) is one of the most common malignancies in the world. The biological mechanisms of hepatocarcinogenesis and progression are poorly understood. Experimental models of HCC provide valuable tools to evaluate the risk factors, new treatment modalities and biologic characteristics. Under the constant evolution in model design and technology development, new experimental models continue to emerge, including spontaneous models, induced models, viral models, transplantable models, and genetically engineered models. These models are used as tools to investigate basic biological mechanisms of growth and differentiation, oncogene function, and as systems to test new diagnostic and therapeutic approaches. Each model has its own advantages and disadvantages. The progress in HCC model construction and studies are summarized in this review.

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Hepatic Neoplasms from Internally Deposited 144CeCl3

Cited by 16 publications

References 20 publications

Age at cancer diagnosis by breed, weight, sex, and cancer type in a cohort of more than 3,000 dogs: Determining the optimal age to initiate cancer screening in canine patients

Age at cancer diagnosis by breed, weight, sex, and cancer type in a cohort of more than 3,000 dogs: Determining the optimal age to initiate cancer screening in canine patients

Age at cancer diagnosis by breed, weight, sex, and cancer type in a cohort of over 3,000 dogs: determining the optimal age to initiate cancer screening in canine patients

Experimental models of hepatocellular carcinoma: developments and evolution

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