Hepatic sarcoidosis associated with chronic hepatitis C

Yamada, Shinwa; Mine, Shinichiro; Fujisaki, Takeshi; Ohnari, Norihiro; Eto, Sumiya; Tanaka, Yoshiya

doi:10.1007/s005350200088

Cited by 19 publications

(9 citation statements)

References 20 publications

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“…IFN‐α is the mainstay treatment for chronic HCV infection since its approval by the FDA in 1991, and that is probably why most cases of IIS have been reported in that population. Similar to other species of viruses and bacteria implicated in the aetiology of sarcoidosis (101), some reports have suggested a potential role for the HCV itself in the development of sarcoidosis (110–112). Chronic HCV infection is associated with immune dysregulation phenomena (such as essential mixed cryoglobulinaemia, autoimmune thyroid disease, sialoadenitis, diabetes mellitus and myasthenia gravis) (113–118) and induces chronic liver damage through a Th‐1 immune type of response (119).…”

Section: Ifn‐induced Sarcoidosis (Iis)mentioning

confidence: 77%

Interferon-induced sarcoidosis

Alazemi

Campos

2005

International Journal of Clinical Practice

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Interferons (IFNs) are widely used for the treatment of various medical diseases. They have marked immunomodulatory effects, and many reports have been published associating IFN therapy with the induction of autoimmune phenomena and other disorders of immune regulation such as sarcoidosis. The clinical presentation of IFN-induced sarcoidosis (IIS) is insidious and can be confused with common constitutional side effects of these drugs. The age of onset of IIS is later than that of naturally occurring sarcoidosis. The most common organs involved are the lungs and skin. In the majority of cases, IIS follows a benign course. As we show in an illustrative case report, complete resolution after discontinuation of IFN therapy can be expected. This review summarises 65 cases of IIS reported in the literature and highlights the pathophysiology, clinical features, diagnostic modalities and therapeutic options for this increasingly recognised phenomenon.

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Section: Ifn‐induced Sarcoidosis (Iis)mentioning

confidence: 77%

Interferon-induced sarcoidosis

Alazemi

Campos

2005

International Journal of Clinical Practice

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“…Mais lorsque ces signes sont associés à des localisations extradigestives de la sarcoïdose, ils doivent faire rechercher de manière systématique les localisations digestives qui sont le plus souvent asymptomatiques [6][7][8]. La cholestase anictérique observée dans tous les cas confirme les données de la littérature [6,[8][9][10]. L'échographie hépatique a confirmé le gros foie dans tous les trois cas.…”

Section: Discussionunclassified

“…D'autres auteurs ont rapporté un cas de sarcoïdose gastrique dont l'endoscopique a évoqué d'abord une linite gastrique, et c'est au cours de l'examen histologique que le diagnostic de certitude de la sarcoïdose a été posé [5]. L'atteinte hépa-tique de la sarcoïdose est retrouvée au cours d'une atteinte systémique pulmonaire, ganglionnaire, oculaire, cutanée, splénique [9][10][11]. Chez nos patients, la sarcoïdose hépatique a été retrouvée au cours des localisations médiastinopulmo-naires comme en précisent les données de la littérature [2,6,7].…”

Section: Discussionunclassified

L’atteinte hépatique au cours de la sarcoïdose

Gassaye

Ibara

Okouo

et al. 2010

J Afr Hepato Gastroenterol

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The hepatic attack to the course of the sarcoïdosis G. Deby · S.-M. Camengo Police · B.-I. Atipo Ibara · M. Okouo · P. Ngoma Nkadoulou · J.-R. Ibara · A. Itoua Ngaporo © Springer-Verlag France 2010Résumé Nous rapportons trois cas d'atteinte hépatique au cours de la sarcoïdose chez des patients âgés respectivement de 43, 45 et 47 ans. Il s'agissait de deux hommes et d'une femme. L'atteinte hépatique s'est manifestée par des douleurs de l'hypochondre droit. L'examen physique a retrouvé un gros foie chez tous les patients. La biologie a été caracté-risée par la cholestase anictérique retrouvée dans tous les cas et une cytolyse hépatique modérée dans deux cas. L'analyse histologique des pièces de ponction-biopsie hépatique a montré des granulomes épithélioïdes et gigantocellulaires sans nécrose caséeuse, évoquant la sarcoïdose. La sarcoïdose a été associée à une hépatite chronique virale C au stade de précirrhose dans un cas (score de Métavir A1 et F2). Tous les patients ont été mis sous corticoïdes. L'évolution a été favorable après en moyenne cinq mois de traitement, mais une récidive a été observée après l'abandon précoce du traitement. Mots clés Sarcoïdose · Foie · BrazzavilleAbstract We report three cases of hepatic attack in sarcoidosis patients aged 43, 45, and 47years, respectively. The patients were two men and a woman. The hepatic attack appeared by pains to the right hypochondrium. Physical examination found an enlarged liver in all patients. The biology was characterized by anicteric cholestasis found in every case and hepatic cytolysis in two cases. The histological analysis of the hepatic biopsy showed epithelioid granulomas and gigantocellulars without necrosis caseum, evoking the sarcoidosis. The sarcoidosis was associated to a chronic hepatitis C virus to the stage of pre cirrhosis in a case (score of Metavir A1 and F2). All patients were put under corticoids. The outcome was favorable after about five months of treatment, but recurrence was observed after early dropout of treatment.

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“…Cases of HCV‐related sarcoidosis have been reported in treatment‐naive patients, 23–25 in those receiving antiviral therapy for HCV 7–13 and in those who had reactivation of previously known sarcoidosis while on antiviral therapy for HCV 14,26,27 . Overall, symptoms of sarcoidosis can occur any time after commencement of antiviral therapy and resolution of symptoms has been widely reported after cessation of antiviral treatment 9–13 .…”

Section: Discussionmentioning

confidence: 99%

Sarcoidosis presenting with granulomatous uveitis induced by pegylated interferon and ribavirin therapy for hepatitis C

Yan

Dinihan

Freiman

et al. 2008

Internal Medicine Journal

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Sarcoidosis is a systemic granulomatous disease that is triggered by an autoimmune process, and is now a well recognized but uncommon complication of antiviral therapy for Hepatitis C virus (HCV) infection, likely related to its immunomodulatory effects. The clinical presentation of HCV related sarcoidosis is as varied as systemic sarcoidosis, but ocular presentation alone has not been reported previously. We present a 23 year-old female who developed visual disturbances due to ocular sarcoidosis during the course of antiviral therapy for chronic HCV infection. Our case presentation is then followed by a review of the literature on the topic. We aim to stress the importance of screening for eye problems in following HCV patients undergoing antiviral therapy, and raise clinicians' awareness of sarcoidosis as a possible cause for eye problems even in the absence of respiratory complaints.

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Hepatic sarcoidosis associated with chronic hepatitis C

Cited by 19 publications

References 20 publications

Interferon-induced sarcoidosis

Interferon-induced sarcoidosis

L’atteinte hépatique au cours de la sarcoïdose

Sarcoidosis presenting with granulomatous uveitis induced by pegylated interferon and ribavirin therapy for hepatitis C

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