2011
DOI: 10.1152/ajpgi.00539.2010
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Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet

Abstract: Garbow JR, Doherty JM, Schugar RC, Travers S, Weber ML, Wentz AE, Ezenwajiaku N, Cotter DG, Brunt EM, Crawford PA. Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet. Am J Physiol Gastrointest Liver Physiol 300: G956 -G967, 2011. First published March 31, 2011 doi:10.1152/ajpgi.00539.2010.-Low-carbohydrate diets are used to manage obesity, seizure disorders, and malignancies of the central nervous system. These diets create a distinctive, but … Show more

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Cited by 151 publications
(183 citation statements)
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“…Furthermore, the increased plasma cytokine concentrations in our study suggest a systemic proinflammatory state in longterm KD-fed mice. This is in line with the observation that short-term KD in mice is associated with increased inflammatory markers in liver and adipose tissue (2) and macrophage infiltration in the liver (16). Also, we show that KD-fed mice had increased plasma levels of the chemokine MCP-1, which is associated with increased macrophage recruitment to the liver (26).…”
Section: Discussionsupporting
confidence: 91%
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“…Furthermore, the increased plasma cytokine concentrations in our study suggest a systemic proinflammatory state in longterm KD-fed mice. This is in line with the observation that short-term KD in mice is associated with increased inflammatory markers in liver and adipose tissue (2) and macrophage infiltration in the liver (16). Also, we show that KD-fed mice had increased plasma levels of the chemokine MCP-1, which is associated with increased macrophage recruitment to the liver (26).…”
Section: Discussionsupporting
confidence: 91%
“…This is in line with metabolic changes observed in previous studies in mice (2,16,20,22) and may indicate an early stage of nonalcoholic fatty liver disease (16,36). Recent short-term studies have shown that supplementation of KD with choline or methionine could limit hepatic steatosis and the proinflammatory state of the liver, respectively (31,37).…”
Section: Discussionsupporting
confidence: 89%
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