Hepatic venoocclusive disease and perisinusoidal fibrosis secondary to arsenic poisoning

Study the Histopathogic Effects of Arsenic Trioxide on Some Parenchymatous Organs of Male Rats and Under Alphalipoic Acid

“…The results of arsenic trioxide toxicity in organs of rat were varied including degeneration , necrosis , inflammatory cellular reaction .together with hemorrhage and congestion in the all organs ,these pathological changes were due to toxicity of ATO lead to liberation of reactive oxygen species and induce oxidative stress (8) which induce tissue damage and necrosis due to effects of superxide , Hydrogen peroxide , hydroxyl and nitric oxid both of these reactive species were released under the effect of ATO in the tissue and its effects were decreased or suppressed due to treatment with alphalipoicacid ( ALA) which was evident in all the organs (9) whom considered that the opposite effect of alphalipoic acid against reactive oxygen species induced by effect of ATO in tissues , other workers reported that the ATO increased infiltration of inflammatory cells like neutrophils and enhance its migration under the effect of inflammatory mediators , protease (10) alphlipoic acid produce its effect as antinflammatory activity and reduced or inhibited inflammatory reaction which is more evident in this study and agreed with (11) .The results in this study indicated that the ATO increased its effect in tissues by oxidative stress mechanism and supplementation with alpha lipoic acid exhibit an opposing action , so protect tissue against ATO toxicity. Liver : is the main target site of ATO toxicity inducing hepatocyte damage , necrosis , vacuolation and fatty change , these finding were consistent with other studies (12) ; all these lesions were reduced or inhibited when animals treated with alphalipoic acid indicating the protective effect of alpha lipoic acid against ATO toxicity ,these results also agreed with (13) The Kidney : also showed extensive pathological lesions characterized by damage , necrosis of renal tubular epithelia , hemorrhage, congestion and inflammatory cellular reaction, all these lesions were occurred as a result of ATO toxicity under effect of reactive oxygen species (14) and the supplementation of alpha lipoic acid ihibit the pathological lesions, these findings agreed with (15) who found that large dose of alpha lipoic acid protect rat against cisplatin induced renal damage .…”

Arsenite stimulates cyclooxygenase‐2 expression through activating IκB kinase and nuclear factor κB in primary and ECV304 endothelial cells

“…Arsenic in deep-well drinking water has been associated with endemic peripheral vascular disease, hepatic veno-occlusive disease, and perisinusoidal ®brosis [Labadie et al, 1990]. Mechanisms for the effects of arsenic on proliferative diseases are unclear.…”

Environmental Pathology

“…A striking increase in hepatocytic mitotic activity was noted in two cases reported by Brenard et al (1996). Hepatic veno-occlusive disease following severe arsenic poisoning was described by Labadie et al (1990). Predominantly cholestatic injury has been reported with the antiamebicidal agent carbarsome and the antisyphilitic drug arsphenamine.…”