Hepatic Venous Congestion After Right-lobe Living-donor Liver Transplantation

Park, Eun‐Ah; Lee, Jeong Min; Kim, Se Hyung; Lee, Min Woo; Han, Joon Koo; Choi, Byung Ihn; Lee, Jae Young; Lee, Whal; Chung, Jin Wook; Park, Jae Hyung

doi:10.1097/01.rct.0000236420.28137.aa

Cited by 15 publications

(10 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in the field of LDLT, impairment of liver regeneration of the anterior section has been reported in donors after left hemiliver graft including the MHV . Furthermore, in recipients of a right hemiliver graft without MHV, the congestive rates in the anterior section were 62% to 92%, and the congestion was also highly related to the venous anatomy . In our present study, patients who underwent left hepatectomy including the MHV showed some congestive and dysfunctional areas in the anterior section.…”

Section: Discussionsupporting

confidence: 40%

See 1 more Smart Citation

An extended dysfunctional area in the congestive area of the remnant liver after hemi‐hepatectomy with middle hepatic vein resection for liver cancers evaluated on the gadoxetic acid disodium‐enhanced magnetic resonance imaging

Ariizumi

Katagiri

et al. 2013

J Hepato Biliary Pancreat

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 40%

“…Computed tomography and MRI can be used to evaluate congestion in the liver graft after transplantation or in the remnant liver of donors . Congestion appeared as high intensity on T2‐weighted MRI .…”

Section: Discussionmentioning

confidence: 99%

An extended dysfunctional area in the congestive area of the remnant liver after hemi‐hepatectomy with middle hepatic vein resection for liver cancers evaluated on the gadoxetic acid disodium‐enhanced magnetic resonance imaging

Ariizumi

Katagiri

et al. 2013

J Hepato Biliary Pancreat

View full text Add to dashboard Cite

show abstract

“…Significant RHV stenosis was diagnosed when there was appreciable weakness of pulsatility or changes in the waveform from a triphasic pattern to a biphasic or monophasic pattern on Doppler ultrasonography and there was concurrent noticeable narrowing of the RHV at the anastomosis within the liver graft or at the IVC on CT scans 19. Hepatic venous congestion was indicated by changes in parenchymal perfusion on CT scans, with or without increases in serum levels of hepatic enzymes 20‐22. A CT scan was undertaken promptly when serum levels of hepatic enzymes (aspartate/alanine aminotransferase) increased rapidly to values >500 IU/L at any time after transplantation.…”

Section: Methodsmentioning

confidence: 99%

Reply:

Solı́s-Herruzo

García-Ruiz

2007

Hepatology

View full text Add to dashboard Cite

We read with great interest the article by Garcia-Ruiz et al., 1 a study which evaluated the effects of rosiglitazone on liver histology and mitochondrial function in ob/ob mice, a model of nonalcoholic fatty liver disease (NAFLD). Briefly, in this controlled study, ob/ob mice were treated at 6 weeks of age with 1 mg/kg/day rosiglitazone by mouth for 12 weeks. Garcia-Ruiz et al. evaluated the effects of rosiglitazone on liver histology and mitochondrial function in the model. They revealed that rosiglitazone treatment improved neither the NAFLD inflammatory activity nor the mitochondrial injury of the model. On the contrary, the drug increased liver steatosis, particularly microvesicular steatosis and oxidative stress compared to control groups.To the best of our knowledge, we presented the first data concerning the effects of rosiglitazone on a nonalcoholic steatohepatitis (NASH) model induced by methionine-choline deficient diet (MCDD). 2,3 We examined the effects of 4 mg/kg/day rosiglitazone given by gavage on histological characteristics of liver in male Wistar rats at 4 and 12 weeks after commencing of feeding either with MCDD or MCDD supplied with methionine and choline (Harlan Teklad Biomedicals, Madison, WI). For grading and staging the histological lesions, the modification system of Brunt et al. was used. 4 All MCDD-fed rats exhibited characteristics of NASH with histological evidence of both significant hepatic steatosis and inflammation. In both study periods, MCDD alone led to grade III liver steatosis, irrespective of rosiglitazone use. Rosiglitazone treatment did not change MCDD-induced liver steatosis in either study terms. The rosiglitazone treatment reduced the number of median inflammatory foci and total inflammatory cells in the MCDD ϩ rosiglitazone group as compared to the MCDD group. Rosiglitazone therapy decreased the liver inflammation on the MCDD-induced NASH model with overt inflammation in both study terms. 2,3 As shown in Garcia-Ruiz et al., we also observed that rosiglitazone appeared to have increased the liver malondialdehyde, luminol, and lucigenin levels; however, these differences were not statistically significant in our studies. 2,3 After cytokine tests, we observed that rosiglitazone also improved interleukin-6 levels in the 4-week study and interleukin-1␤, interleukin-6, and tumor necrosis factor-␣ levels in the 12-week study (P Ͻ 0.01). 3 Our data are the first to show the anti-inflammatory effects of rosiglitazone in NASH. We speculated that rosiglitazone's effect on cytokines may be a key mechanism of its anti-inflammatory effect in NASH.Different NAFLD models may have different responses in terms of severity. Young ob/ob mice have been known to have fatty livers without overt histological or biological evidence of hepatic inflammation (that is, steatohepatitis). 5 Obese ob/ob mice with fatty liver and obvious steatohepatitis have been developed when challenged with lipopolysaccharide endotoxin, 6 ischemia-reperfusion, or ethanol. 7 Because we used an overt NASH ...

show abstract

“…Multiphase contrast enhanced CT, Doppler ultrasonography, and MRI are all used to non-invasively evaluate hepatic venous congestion after liver transplantation [16][17][18]. However, these imaging modalities can hardly provide quantitative measurements of segmental congestion.…”

Section: Perfusion Imaging In Liver Transplantationmentioning

confidence: 99%

Abdominal Perfusion Computed Tomography

Oğul

Bayraktutan

Kizrak

et al. 2013

EAJM

View full text Add to dashboard Cite

The purpose of this article is to provide an up to date review on the spectrum of applications of perfusion computed tomography (CT) in the abdomen. New imaging techniques have been developed with the objective of obtaining a structural and functional analysis of different organs. Recently, perfusion CT has aroused the interest of many researchers who are studying the applicability of imaging modalities in the evaluation of abdominal organs and diseases. Per-fusion CT enables fast, non-invasive imaging of the tumor vascular physiology. Moreover, it can act as an in vivo biomarker of tumor-related angiogenesis.

show abstract

Hepatic Venous Congestion After Right-lobe Living-donor Liver Transplantation

Abstract: A hypoattenuating area of the liver during DP scans indicates severe hepatic congestion and is correlated with hyperbilirubinemia and a high mortality rate.

Cited by 15 publications

References 24 publications

An extended dysfunctional area in the congestive area of the remnant liver after hemi‐hepatectomy with middle hepatic vein resection for liver cancers evaluated on the gadoxetic acid disodium‐enhanced magnetic resonance imaging

An extended dysfunctional area in the congestive area of the remnant liver after hemi‐hepatectomy with middle hepatic vein resection for liver cancers evaluated on the gadoxetic acid disodium‐enhanced magnetic resonance imaging

Reply:

Abdominal Perfusion Computed Tomography

Contact Info

Product

Resources

About