Hepatic venous pressure gradient measurement in pre-primary and primary prophylaxis of variceal hemorrhage

Vorobioff, Julio; Groszmann, Roberto J.

doi:10.1016/s1665-2681(19)31381-x

Cited by 17 publications

(12 citation statements)

References 62 publications

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“…It has been proposed that serial HVPG measurement could assess fibrosis or cirrhosis despite etiology 10,11. Taken together, HVPG measurement can be used in the diagnosis of liver fibrosis, risk stratification, identification of patients with hepatocellular carcinoma who are candidates for liver resection, monitoring of the efficacy of medical treatment, and assessment of progression of portal hypertension 5,8,12,13,14,15…”

Section: Introductionmentioning

confidence: 99%

Hepatic venous pressure gradient: clinical use in chronic liver disease

Suk

2014

Clin Mol Hepatol

119

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Portal hypertension is a severe consequence of chronic liver diseases and is responsible for the main clinical complications of liver cirrhosis. Hepatic venous pressure gradient (HVPG) measurement is the best available method to evaluate the presence and severity of portal hypertension. Clinically significant portal hypertension is defined as an increase in HVPG to >10 mmHg. In this condition, the complications of portal hypertension might begin to appear. HVPG measurement is increasingly used in the clinical fields, and the HVPG is a robust surrogate marker in many clinical applications such as diagnosis, risk stratification, identification of patients with hepatocellular carcinoma who are candidates for liver resection, monitoring of the efficacy of medical treatment, and assessment of progression of portal hypertension. Patients who had a reduction in HVPG of ≥20% or to ≤12 mmHg in response to drug therapy are defined as responders. Responders have a markedly decreased risk of bleeding/rebleeding, ascites, and spontaneous bacterial peritonitis, which results in improved survival. This review provides clinical use of HVPG measurement in the field of liver disease.

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Section: Introductionmentioning

confidence: 99%

Hepatic venous pressure gradient: clinical use in chronic liver disease

Suk

2014

Clin Mol Hepatol

119

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“…Possible explanation of association between alcohol intake and chronic liver injury is alcohol potentiation of other hepatotoxins present in the environment at subtoxic levels, according to Hall [18]. Besides, alcohol intake often leads to a rapid increase of portal pressure, which is a common complication of cirrhosis [19]. According to the report, liver fi brosis and cirrhosis is also associated with immune dysfunction in various types, justifying liver cirrhosis being descripted as a common immunodefi ciency syndrome [20].…”

Section: Occurrence Of Hepatic Fi Brosis and Cirrhosismentioning

confidence: 99%

Occurrence, diagnosis and management of hepatic fibrosis and cirrhosis: An updated literature review

Qiao¹

2019

Arch Hepat Res

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Background: Hepatic fi brosis and cirrhosis, characterized with signifi cant morbidity and mortality, have always been worldwide health care problems. Objective: This manuscript is aimed at providing a research progress overview of hepatic fi brosis and cirrhosis. Method: Online search for articles published in years from 2009 to 2019 with "hepatic fi brosis", "cirrhosis", "therapy", "liver disease" and "hepatitis" as keywords. The adopted database involves PubMed, MIDLINE, Google Scholar, CNKI and EMBASE. Result: This review summarizes the latest fi ndings about pathogenesis, diagnosis and therapies of hepatic fi brosis and cirrhosis, and describes their application prospect and future research directions, providing references to some extent for fellow academics.

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“…Endoscopy detects and grades the esophageal varices, Abdominal Imaging but it is an invasive procedure and is not accepted by many patients [1][2][3]. The hepatic vein pressure gradient is considered to be the gold standard for diagnosis of portal hypertension and esophageal varices in cirrhotic patients, but this is an invasive and expensive procedure that may be associated with potential complications [3,14]. Therefore, there is still a need for reliable, simple and non-invasive method for prediction of esophageal varices in cirrhotic patients.…”

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confidence: 99%