Hepatic Δ9 desaturating activity in genetically lean and fat chickens

Legrand, Philippe; Lemarchal, P.

doi:10.1016/b978-0-408-01036-8.50024-5

Cited by 26 publications

(33 citation statements)

References 4 publications

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“…Legrand and Lemarchal (1988) showed that hepatic D9 desaturating activity was higher in 11-week-old FL birds than in LL birds (41.1 v. 11.7 nmol/min per g liver), suggesting a higher rate of VLDL secretion.…”

Section: Plasma Lipidsmentioning

confidence: 92%

Chicken lines divergent for low or high abdominal fat deposition: a relevant model to study the regulation of energy metabolism

Baéza¹,

Bihan-Duval²

2013

Animal

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Divergent selection of chickens for low or high abdominal fat (AF) but similar BW at 63 days of age was undertaken in 1977. The selection programme was conducted over seven successive generations. The difference between lines was then maintained constant at about twice the AF in the fat line as in the lean line. The aims of the first studies on these divergent chicken lines were to describe the growth, body composition and reproductive performance in young and adult birds. The lines were then used to improve the understanding of the relationship between fatness and energy and protein metabolism in the liver, muscle and adipose tissues, as well as the regulation of such metabolism at hormonal, gene and hypothalamic levels. The effects on muscle energy metabolism in relation to meat quality parameters were also described. This paper reviews the main results obtained with these lines.

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Section: Plasma Lipidsmentioning

confidence: 92%

Chicken lines divergent for low or high abdominal fat deposition: a relevant model to study the regulation of energy metabolism

Baéza¹,

Bihan-Duval²

2013

Animal

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“…Studies performed in lean and fat line by Leclercq et al (1980) indicated that the difference in adiposity between lines was not the result of a difference in food consumption or in metabolic utilization of energy. Stearoyl-CoA desaturase activity and plasma VLDL concentration were found to be higher in the fat line (Legrand and Hermier, 1992), suggesting a higher lipogenesis rate in this line. Body Selection for high VLDL has increase the proportion of circulating VLDL-triglyceride taken up by the abdominal fat pad by over 2 fold, but there was no difference between high and low VLDL lines in the proportion of VLDL triglyceride taken up by tissues and oxidized to 14C -carbon dioxide (Griffin et al, 1991).…”

Section: Discussionmentioning

confidence: 91%

“…Studies performed in lean and fat line by (Leclercq et al, 1980) indicated that the difference in adiposity between lines was not the result of a difference in food consumption or in metabolic utilizetion of energy. Stearoyl-CoA desaturase activity and plasma VLDL concentration were found to be higher in the fat line, suggesting a higher lipogenesis rate in this line (Legrand and Hermier, 1992).…”

Section: *Correspondingmentioning

confidence: 99%

Association of polymorphisms in avian apoVLDL-II gene with body weight and abdominal fat weight

Musa¹,

Chen²

2007

Afr. J. Biotechnol.

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To investigate the association of avian apoVLDL-II gene polymorphism with body weight and fat, exactly 120 genetically fat (Anka) and lean (Rugao) chicken reared under the same environment and management were selected. Blood samples from the respective populations were taken for DNA extraction, and then slaughter for fat determination. Polymorphism was detected by PCR-RFLP and PCR-SSCP techniques. Gene frequency was non significantly different between population at VLDL6 and VLDL10 loci. However, in VLDL9 and VLDL17 loci the gene frequency was differed significantly (P<0.01) between populations. Polymorphism in apoVLDL-II gene was significantly (P<0.05) associated with body weight and fat weight at VLDL9 and VLDL17 loci in lean chicken. In addition, polymorphism of apoVLDL-II gene at VLDL6, VLDL9 and VLDL10 loci was significantly (P<0.05) associated with body weight and fat weight.

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“…Hence, the SCD1 transcript level could be considered as an indicator of the SCD1 enzyme activity. Moreover, in the chicken, several studies have shown that hepatic SCD1 enzyme and the subsequent availability of endogenous oleic acid have an enhancing effect on the hepatic triglyceride secretion [28,29, Diot, Laboratoire de génétique animale, INRA, Rennes, France, personal communication]. Mono-unsaturated fatty acids would be incorporated more easily into triglycerides and subsequently into VLDL, which would facilitate their hepatic secretion [25,37].…”

Section: Discussionmentioning

confidence: 99%

Hepatic lipogenesis gene expression in two experimental egg-laying lines divergently selected on residual food consumption

Lagarrigue¹,

Daval²,

Bordas

et al. 2000

Genet Sel Evol

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-Two Rhode Island Red egg-laying lines have been divergently selected on residual food intake (low intake R − line, high intake R + line) for 19 generations. In addition to direct response, correlated responses have altered several other traits such as carcass adiposity and lipid contents of several tissues, the R + animals being leaner than the R − ones. In a search for the biological origin of the differences observed in fat deposit, the hepatic mRNA amounts of genes involved in lipid metabolism were investigated. No difference was found between lines for mRNA levels of ATP citrate-lyase, acetyl-CoA carboxylase, fatty acid synthase, malic enzyme and CCAAT/enhancer binding protein α, a transcription factor acting on several lipogenesis genes. The genes coding for stearoyl-CoA desaturase and apolipoprotein A1 displayed significantly lower mRNA levels in the R + cockerels compared to the R − . All together these mRNA levels explained 40% of the overall variability of abdominal adipose tissue weight, suggesting an important role of both genes in the fatness variability.laying fowl / food efficiency / fatness / mRNA / liver Résumé -Expression hépatique de gènes de la lipogénèse chez des lignées divergentes de poules pondeuses sélectionnées sur la consommation alimentaire résiduelle. Deux lignées de poules pondeuses Rhode Island Red ontété sélectionnées de façon divergente sur la consommation alimentaire résiduelle (R − /R + ) pendant

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Hepatic Δ9 desaturating activity in genetically lean and fat chickens

Cited by 26 publications

References 4 publications

Chicken lines divergent for low or high abdominal fat deposition: a relevant model to study the regulation of energy metabolism

Chicken lines divergent for low or high abdominal fat deposition: a relevant model to study the regulation of energy metabolism

Association of polymorphisms in avian apoVLDL-II gene with body weight and abdominal fat weight

Hepatic lipogenesis gene expression in two experimental egg-laying lines divergently selected on residual food consumption

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