Hepatitis D virus (HDV) infection leads to severe acute and chronic liver disease in patients infected with hepatitis B virus (HBV). It is common among HBV-infected patients globally. HDV has an estimated prevalence of 4.5% among HBsAg-positive individuals. It is responsible for an estimated 18% of cirrhosis and 20% of HCC associated with hepatitis B. 1 An estimated 257-291 million people are chronically infected with HBV, 2 corresponding to 11-13 million individuals coinfected with HDV.