Hepatitis aguda asociada a ingestión de camellia thea y orthosiphon stamineus

García-Morán, Sara; Sáez-Royuela, F; Gento, Elena; Morante, Aristide; Arias, Lara

doi:10.1016/s0210-5705(03)70527-5

Cited by 27 publications

(13 citation statements)

References 7 publications

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“…Assumed causality was mostly based on clinical judgment, rarely on the results of liver specific causality assessment methods [70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135…”

Section: Tcm Herbs With Published Claims Of Hepatotoxic Potentialmentioning

confidence: 99%

“…Information on the amounts of green tea in these two products was not provided. At least as extract, Camellia sinensis is a potent weight loss aid with potentially hepatotoxic effects, as thoroughly discussed first in 2004 [131,132,133] and in subsequent years as shown for many cases [134,135,136,137,138,139,140,141,142,143,144]. Therefore, hepatotoxicity of green tea as extracts was not yet clearly established in 2003 when the case reports were published [93].…”

Section: Narratives Of Tcm Hili Casesmentioning

confidence: 99%

“…Liver injury due to green tea extracts (GTE) has been reported as single cases [131,132,133,134,135,142], case series [136,137,138,139,141,144], and discussed in review articles [60,139,140,141,180]. Overall, more than 100 suspected cases of liver injury by GTE have been published [60,180], while details of other cases are provided by the NIH liver Tox [47].…”

Section: Narratives Of Tcm Hili Casesmentioning

confidence: 99%

“…An additional 135 Onshido-induced cases of hepatotoxicity were reported to the regulatory agency in Japan but not further analyzed [93]. A possible role of Camellia sinensis for the observed hepatotoxicity of Onshido was not discussed in 2003 [93], because hepatotoxic properties of Camellia sinensis extracts became only known in 2004 [132,133,134]. For additional details and discussions, see also Chaso and Lu Cha ( Camellia sinensis ).…”

Section: Narratives Of Tcm Hili Casesmentioning

confidence: 99%

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Traditional Chinese Medicine (TCM) and Herbal Hepatotoxicity: RUCAM and the Role of Novel Diagnostic Biomarkers Such as MicroRNAs

et al. 2016

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Background: Traditional Chinese Medicine (TCM) with its focus on herbal use is popular and appreciated worldwide with increased tendency, although its therapeutic efficacy is poorly established for most herbal TCM products. Treatment was perceived as fairly safe but discussions emerged more recently as to whether herb induced liver injury (HILI) from herbal TCM is a major issue; Methods: To analyze clinical and case characteristics of HILI caused by herbal TCM, we undertook a selective literature search in the PubMed database with the search items Traditional Chinese Medicine, TCM, alone and combined with the terms herbal hepatotoxicity or herb induced liver injury; Results: HILI caused by herbal TCM is rare and similarly to drugs can be caused by an unpredictable idiosyncratic or a predictable intrinsic reaction. Clinical features of liver injury from herbal TCM products are variable, and specific diagnostic biomarkers such as microsomal epoxide hydrolase, pyrrole-protein adducts, metabolomics, and microRNAs are available for only a few TCM herbs. The diagnosis is ascertained if alternative causes are validly excluded and causality levels of probable or highly probable are achieved applying the liver specific RUCAM (Roussel Uclaf Causality Assessment Method) as the most commonly used diagnostic tool worldwide. Case evaluation may be confounded by inappropriate or lacking causality assessment, poor herbal product quality, insufficiently documented cases, and failing to exclude alternative causes such as infections by hepatotropic viruses including hepatitis E virus infections; Conclusion: Suspected cases of liver injury from herbal TCM represent major challenges that deserve special clinical and regulatory attention to improve the quality of case evaluations and ascertain patients’ safety and benefit.

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Section: Tcm Herbs With Published Claims Of Hepatotoxic Potentialmentioning

confidence: 99%

Section: Narratives Of Tcm Hili Casesmentioning

confidence: 99%

Section: Narratives Of Tcm Hili Casesmentioning

confidence: 99%

Section: Narratives Of Tcm Hili Casesmentioning

confidence: 99%

See 2 more Smart Citations

Traditional Chinese Medicine (TCM) and Herbal Hepatotoxicity: RUCAM and the Role of Novel Diagnostic Biomarkers Such as MicroRNAs

et al. 2016

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“…Первый отчет о поражении пе-чени, связанный с потреблением экстракта зеленого чая, был опубликован в 1999 году [29]. После этого было описано значительное число случаев поражения печени, связанных с потреблением различных БАДов, содержа-щих экстракты зеленого чая [7,12,[29][30][31][32][33][34][35][36][37][38][39][40]. Опубликованные случаи гепатотоксичности экстрактов зеленого чая из США, Велико-британии и Австралии до 2008 года были рассмотрены Фармакопеей США.…”

Section: экстракт зеленого чая (Camellia Sinensis)unclassified