Hepatitis B

Gerlich, Wolfram H.; Kann, Michael

doi:10.1002/9780470688618.taw0261

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Introduction1

Envelopment and Release1

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2015

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Article2

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Cited by 2 publications

(2 citation statements)

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“…Replication of HBV involves reverse transcription (RT) of pregenomic viral RNA (pgRNA) packaged into viral capsids. 7 Transcription of pgRNA is tightly regulated by pg cp/EII. 8 cp/EII seems to be a central element in the regulation of viral replication, and many variants from natural infection that change the replicative properties of HBV have been described.…”

Section: Introductionmentioning

confidence: 99%

Molecular Mechanism of p73-Mediated Regulation of Hepatitis B Virus Core Promoter/Enhancer II: Implications for Hepatocarcinogenesis

Buhlmann

Raček

Schwarz

et al. 2008

Journal of Molecular Biology

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Section: Introductionmentioning

confidence: 99%

Molecular Mechanism of p73-Mediated Regulation of Hepatitis B Virus Core Promoter/Enhancer II: Implications for Hepatocarcinogenesis

Buhlmann

Raček

Schwarz

et al. 2008

Journal of Molecular Biology

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“…Co-assembly of particles with higher amounts of L (ratio of 1:1:4 of L:M:S) leads to the formation of filamentous structures (Heermann et al 1984; Short et al 2009). Yeast-expressed recombinant S-HBsAg is the basis of the HBV vaccine (Gerlich and Kann 2010). …”

Section: Envelopment and Releasementioning

confidence: 99%

Assembly and Release of Hepatitis B Virus

Selzer

Zlotnick

2015

Cold Spring Harb Perspect Med

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The HBV core protein is a dynamic and versatile protein that directs many viral processes. During capsid assembly, core protein allosteric changes ensure efficient formation of a stable capsid that assembles while packaging viral RNA-polymerase complex. Reverse transcription of the RNA genome as well as transport of the capsid to multiple cellular compartments, are directed by dynamic phosphorylation and structural changes of core protein. Subsequently, interactions of the capsid with the surface proteins and/or host proteins trigger envelopment and release of the viral capsids or the transport to the nucleus. Held together by many weak protein-protein interactions, the viral capsid is an extraordinary metastable machine that is stable enough to persist in the cellular and extracellular environment but dissociates to allow release of the viral genome at the right time during infection.

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Hepatitis B

Cited by 2 publications

References 265 publications

Molecular Mechanism of p73-Mediated Regulation of Hepatitis B Virus Core Promoter/Enhancer II: Implications for Hepatocarcinogenesis

Molecular Mechanism of p73-Mediated Regulation of Hepatitis B Virus Core Promoter/Enhancer II: Implications for Hepatocarcinogenesis

Assembly and Release of Hepatitis B Virus

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