Hepatitis B vaccination and reduced risk of primary liver cancer among male adults: a cohort study in Korea

Lee, Moo-Song; Kim, Dong-Hyun; Kim, Heon; Lee, Hyo-Suk; Kim, Chung-Yong; Park, Tae‐Soo; Yoo, Keun-Young; Park, Byung Joo; Ahn, Yoon‐Ok

doi:10.1093/ije/27.2.316

Cited by 61 publications

(45 citation statements)

References 6 publications

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“…Figure 4 Selected examples of the strength of the associations (RR/ OR) between risk factors and human cancer; estimates of the attributable fraction (AF%) and of the protective fraction (PF%). Refs: the Philippines, 28 Costa Rica, 37 Bangkok, 5 Taiwan, 43 Greece, 44 Italy, 45 UK, 46 Korea, 47 and Taiwan. 71 Colgan et al (1989) 70 Yokota et al (1990) 69 Zhang et al (1990) 68 Chang et al (1990) 67 Si et al (1991) 66 Wei et al (1991) 65 Ohta et al (1991) 64 Saito et al (1992) 63 Mandelblatt et al (1992) 62 Kadish et al (1992) 61 Kanetsky et al (1992) 60 Lörincz et al (1992) 59 Marin et al (1994) 58 squamous cell carcinomas and adenocarcinomas, the consistency of findings between preinvasive disease and invasive cancer, and the consistency of findings between risk estimates for HPV DNA (all types considered) and risk estimates restricted to high risk types.…”

Section: Strength Of Association Evaluationmentioning

confidence: 99%

The causal relation between human papillomavirus and cervical cancer

Bosch

Lörincz²,

Muñóz

et al. 2002

Journal of Clinical Pathology

3,030

2,122

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Section: Strength Of Association Evaluationmentioning

confidence: 99%

The causal relation between human papillomavirus and cervical cancer

Bosch

Lörincz²,

Muñóz

et al. 2002

Journal of Clinical Pathology

3,030

2,122

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“…The high incidence rate of HCC is thought to be related to the high carrier rate of HBV in the general population. The mean HBsAg-positive rate among the Korean population was 5.1% in men and 4.1% in women according to a national health survey carried out in 1998 [15, 16]. …”

Section: Factors Related To Hcc Occurrencementioning

confidence: 99%

“…For primary prevention, a nationwide HBV vaccination program has been conducted since the late 1980s in Korea and, 20 years later, the number of children positive for HBsAg has fallen substantially from 7–8 to 0.6%. Along with this decrease in the HBsAg carrier status, HCC development is expected to decrease in the near future [15, 24]. Secondary prevention is effected by interfering with the metabolism of the carcinogen, or by preventing it from reaching its target.…”

Section: Treatment and Prevention For Suppression Of Hcc Incidencementioning

confidence: 99%

Epidemiology of Hepatocellular Carcinoma in Japan and Korea

et al. 2008

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The worldwide burden of liver cancer has been estimated at 671,000 new cases for the year 2005. Hepatocellular carcinoma (HCC) accounts for between 85 and 90% of primary liver cancer and is one of the most frequent malignancies in Asia. In both Japan and Korea, the incidence exceeds 25 cases/100,000/year and ranks third in cancer deaths after stomach and lung cancer. In Korea the number of deaths from liver cancer increased from approximately 5,789 in 1983 to 9,966 in 1994, and then remained steady at 9,500/100,000 in 2003. In Japan the number of deaths from HCC increased until 2002, and then decreased to 34,089 in 2003, up to 15% of HCC cases are caused by hepatitis B virus (HBV) and ∼80% by hepatitis C virus (HCV) infection; the corresponding figures in Korea are ∼70 and ∼20%. Recent clinical data have shown that interferon and lamivudine treatment is effective in preventing the occurrence of HCC attributed to HCV and HBV infection, respectively, and that an aggressive vaccination program against the latter reduces the incidence of HCC. With the enormous efforts of researchers devoted to basic and clinical studies, the incidence of HCC is expected, in the near future, to gradually decline in both countries.

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“…PGA is an application specifically designed to calculate statistical power and other values of case-control genetic association studies. For the present study, a co-dominant (1df) model with relative risk 1.3, disease prevalence value 7.1% (Lee et al, 1998), EDF (Effective Degree of Freedom) 2, and alpha error level 5% were used to calculate the statistical power of p-values for HBV clearance and HCC occurrence.…”

Section: Statisticsmentioning

confidence: 99%

Identification of Polymorphisms in CYP2E1 Gene and Association Analysis among Chronic HBV Patients

Chun¹,

Park²,

Cheong³

et al. 2009

Genomics & Informatics

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Cytochrome P450 2E1 (CYP2E1) is a member of the cytochrome P450 superfamily, and it is a key enzyme responsible for the metabolic activation of many smallmolecular-weight compounds such as alcohol, which is classified as a human carcinogen. In this study, we identified 19 single nucleotide polymorphisms (SNPs) in CYP2E1 in Korean population. In these SNPs, we examined possible genetic association of CYP2E1 polymorphisms with HBV clearance and the risk of hepatocellular carcinoma (HCC). Five common polymorphic sites were selected, CYP2E1 polymorphisms at rs381-3867, rs3813870, rs2070673, rs2515641 and rs2480257, considering their allele frequencies, haplotype-tagging status and LDs for genotyping in larger-scale subjects (n=1,092). Statistical analysis demonstrated that CYP2E1 polymorphisms and haplotypes show no significant association with HBV clearance, HCC occurrence and onset age of HCC (p＞0.05). Previous studies, however, have shown contradictory findings on associations of CYP2E1 polymorphisms with CYP2E1 activities and HCC risk. Comparing the contrasting results of previous researches suggest that CYP2E1 polymorphism is associated with CYP2E1 activity induced by ethanol, but is not directly associated with HCC risk. CYP2E1 variation/haploype information identified in this study will provide valuable information for future studies on CYP2E1.

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Hepatitis B vaccination and reduced risk of primary liver cancer among male adults: a cohort study in Korea

Abstract: This study suggested that artificial immunization through HBV vaccination, even in adulthood, reduces the risk of liver cancer. It might also offer a practicable means of primary prevention, especially in areas with hyperendemicity of HBV infection.

Cited by 61 publications

References 6 publications

The causal relation between human papillomavirus and cervical cancer

The causal relation between human papillomavirus and cervical cancer

Epidemiology of Hepatocellular Carcinoma in Japan and Korea

Identification of Polymorphisms in CYP2E1 Gene and Association Analysis among Chronic HBV Patients

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