Hepatitis B Virus-Associated Hepatocellular Carcinoma from India: Role of Viral Genotype and Mutations in CTNNB1 (Beta-Catenin) and TP53 Genes

Vivekanandan, Perumal; Torbenson, Michael; Ramakrishna, B. S.

doi:10.1007/s12029-010-9222-4

Cited by 10 publications

(13 citation statements)

References 31 publications

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“…EpCAM is one of the markers that identify CSCs within a tumour 19 20 . Signaling pathways in HCC in Indian patients may be different from those in the West 21 22 , underscoring the importance of re-examining the biological correlates of CSC and HCC in this population.…”

Section: Discussionmentioning

confidence: 99%

Cancer stem cells in hepatocellular carcinoma - an immunohistochemical study with histopathological association

Matthai¹,

Ramakrishna²

2015

Indian J Med Res

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Background & objectives:Cancer stem cells (CSCs) may be responsible for tumour recurrence and resistance to chemotherapy in hepatocellular carcinoma (HCC). This study was carried out to evaluate the association between histological parameters and liver CSCs (LCSC) in HCC, and to compare distribution of liver CSCs in HCC associated with and without hepatitis B virus (HBV) infection.Methods:Seventy nine tumours (49 surgical resections from 46 patients, and 30 from autopsy) were reviewed. Immunohistochemical staining for the LCSC marker EpCAM (epithelial cell adhesion molecule), liver progenitor cell (LPC) markers CK19 (cytokeratin 19) and neural cell adhesion molecule (NCAM) were performed and were associated with histological features of tumour behaviour.Results:Thirty three tumours (41.8%) showed positive staining for EpCAM. CK19 and NCAM expression were seen in 26 (32.9%) and four (5.1%) tumours, respectively. The expression of EpCAM and CK19 was significantly associated with each other (P<0.001). EpCAM expression was significantly associated with clinical and histological features indicating aggressive tumour behaviour, including younger age of onset, higher serum alpha foetoprotein (AFP) levels, tumour cell dedifferentiation, increased mitotic activity, and vascular invasiveness. There was no significant difference in expression of EpCAM, CK19 and NCAM between HBV positive and negative HCC.Interpretation & conclusions:The LCSC marker EpCAM was expressed in less than half of HCC, was independent of HBV aetiology, and was strongly associated with clinical and histological features of aggressive tumour behaviour. Positive staining for CK19 suggests a possible LPC origin of the EpCAM positive HCCs.

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Section: Discussionmentioning

confidence: 99%

Cancer stem cells in hepatocellular carcinoma - an immunohistochemical study with histopathological association

Matthai¹,

Ramakrishna²

2015

Indian J Med Res

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“…The very low frequency of TP53 mutation suggests low levels of Aflatoxin B1 exposure. 40 Because of the discrepant and isolated reports on genetic risk factors for HCC it can be concluded that currently data is insufficient to implicate any genetic risk factor for HCC in India. Table 1 shows among the HCC patients without cirrhosis, 63.46% were positive for HBV markers, 1.92% for HCV markers and none had markers for both.…”

Section: Are Indians Genetically More Prone To Hepatocellular Carcinoma?mentioning

confidence: 99%

Risk Factors for Hepatocellular Carcinoma in India

Kar

2014

Journal of Clinical and Experimental Hepatology

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Hepatocellular carcinoma (HCC) is an important cause of death all over the world, more so in Asia and Africa. The representative data on epidemiology of HCC in India is very scanty and cancer is not a reportable disease in India and the cancer registries in India are mostly urban. 45 million people who are suffering from chronic Hepatitis B virus (HBV) infection and approximately 15 million people who are afflicted with chronic Hepatitis C virus (HCV) infection in India. HBV and HCV infection is considered an important etiologic factor in HCC. Positive association between HCC and consumption of alcohol where alcohol contribute as a cofactor for hepatotoxins and hepatitis viruses. Aflatoxin contamination in the diets, Hepatitis B virus infection and liver cirrhosis in Andhra Pradesh, India and direct chronic exposure to aflatoxins was shown to cause liver cirrhosis. Cirrhosis of liver of any cause lead to develop about 70%-90% of HCC. Aflatoxin interact synergistically with Hepatitis B virus (HBV)/Hepatitis C virus (HCV) infection which increase the risk of HCC. HBV infection, HBV infection with Aflatoxin exposure, viral infection and alcohol consumption leading to overt cirrhosis of the liver, alcohol consumption leading to cirrhosis of the liver with viral infection are the predominant risk factor for the development of HCC. HCV and alcohol are also associated with HCC in India. Indians develop diabetes at younger age, Asians have strong genetic susceptibility for type II diabetes. Diabetes mellitus is identified as a risk factor for HCC. Prevention of viral infection by universal vaccination against hepatitis virus, HCC surveillance program, preventing alcoholic liver diseases, fungal contamination of grains and ground crops to prevent basically Aflatoxin exposure are important measures to prevent liver diseases and HCC among those at risk. ( J CLIN EXP HEPATOL 2014;4:S34-S42)

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“…We did not find nuclear staining for beta catenin in tumor cells of both HCC and FLC in the present case. Our previous study [ 12 ] has also shown that the beta-catenin pathway appears to be infrequent in hepatitis B related HCC in India.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B Virus-Associated Hepatocellular Carcinoma from India: Role of Viral Genotype and Mutations in CTNNB1 (Beta-Catenin) and TP53 Genes

Cited by 10 publications

References 31 publications

Cancer stem cells in hepatocellular carcinoma - an immunohistochemical study with histopathological association

Cancer stem cells in hepatocellular carcinoma - an immunohistochemical study with histopathological association

Risk Factors for Hepatocellular Carcinoma in India

Combined Hepatocellular Carcinoma and Fibrolamellar Carcinoma Presenting as Two Adjacent Separate Lesions in a Young Boy: First Case Report from Asia

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