Hepatitis B virus infection and vaccine-induced immunity in Madrid (Spain)

Pedraza-Flechas, Ana María; García-Comas, Luis; Ordobás-Gavín, María; Sanz-Moreno, Juan Carlos; Ramos-Blázquez, Belén; Astray‐Mochales, Jenaro; Moreno-Guillén, Santiago

doi:10.1016/j.gaceta.2014.05.007

Cited by 6 publications

(8 citation statements)

References 9 publications

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“…The HBsAg prevalence in the general population of the neighboring countries ranges from 0.1% in Ireland to 0.8% in Spain . In line with our findings, a higher HBV prevalence was found in FGMs born in intermediate‐ or high‐prevalence areas in comparison to the native population of countries such as France, Germany, the Netherlands, and Spain …”

Section: Discussionsupporting

confidence: 91%

Prevalence and risk factors of hepatitis B virus infection in Middle‐Limburg Belgium, year 2017: Importance of migration

Koc

Kremer

Bielen

et al. 2019

Journal of Medical Virology

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Background and Aim: The hepatitis B virus (HBV) prevalence study performed in 2003 in Belgium is believed to be underestimating HBV prevalence due to underrepresentation of the non-Belgian population. Therefore, we assessed the prevalence and risk factors of HBV infection in a multi-ethnic region situated in Middle-Limburg Belgium, in 2017. Methods: Between May and November 2017, blood samples and questionnaires were taken from patients who presented at the emergency department of a large educational hospital. Blood samples were tested for hepatitis B surface antigen (HBsAg) and hepatitis B core antibodies (anti-HBc). A sample size of 1000 persons was required to obtain a representative sample of the general Middle-Limburg population.Results: Of the 1131 patients screened, the overall HBsAg prevalence was 0.97% with differences between Belgians (0.67%) and first-generation-migrants (2.55%), (P = 0.015). Five (45.5%) of 11 HBsAg-positive individuals were not aware of their HBV status. All five (100%) newly diagnosed HBsAg-positive patients had further clinical evaluation and all had a normal level of alanine aminotransferase (ALT). The prevalence of anti-HBc was 8.4%, and was significantly associated with age-genderethnicity interaction, presence of HBV-infected household member, hepatitis C virus infection, men who have sex with men, and hemodialysis. Conclusions:In this area with large immigrant populations, we found a higher prevalence of HBV infection compared with the nationwide study of 2003. National HBV screening for first-generation migrants is needed as this high-risk group will go unnoticed due to the possible incorrect interpretation of normal ALT values. K E Y W O R D SBelgium, hepatitis B, migrants, prevalence, risk factors

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Section: Discussionsupporting

confidence: 91%

Prevalence and risk factors of hepatitis B virus infection in Middle‐Limburg Belgium, year 2017: Importance of migration

Koc

Kremer

Bielen

et al. 2019

Journal of Medical Virology

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“…1.23 per 100,000 population. Higher rates of HBsAg positivity among men have been described in several European countries [31-33]. Sex differences could be attributed to higher risk behaviour among men, particularly MSM.…”

Section: Discussionmentioning

confidence: 99%

Acute hepatitis B notification rates in Flanders, Belgium, 2009 to 2017

Koc

Damme²,

Busschots

et al. 2019

Eurosurveillance

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Background Belgium is a low-endemic country for hepatitis B. Universal hepatitis B vaccination in infants with catch-up in the age cohort of 10–13 year-olds began in 1999. Aims Our objective was to evaluate the effect of prevention and control strategies on acute hepatitis B notification rates in Flanders (Belgium) from 2009 to 2017. Methods This observational study collected demographic data and risk factors for acute hepatitis B from mandatory notifications to the Agency for Care and Health. Results In Flanders, acute hepatitis B notification rates per 100,000 population decreased from 1.6 in 2009 to 0.7 in 2017. These rates declined in all age groups: 0–4-year-olds: 0.6 to 0.0, 5–14-year-olds: 0.2 to 0.0, 15–24-year-olds: 0.8 to 0.7, 25–34-year-olds: 3.4 to 1.1 and ≥ 35-year-olds: 1.59 to 0.7. There was also a downward trend in acute hepatitis B notification rates in native Belgians and first-generation migrants. Among 15–24-year-olds and 25–34-year-olds, a possible reversal of the decreasing trend was observed in 2016 and 2015, respectively. Among 548 acute hepatitis B cases, the main route of transmission was sexual activity (30.7%), and the pattern of transmission routes over time showed an increasing proportion of sexual transmission in men who have sex with men (MSM) after 2014. During the period from 2009 to 2017, five mother-to-child transmissions were reported. Conclusions Prevention and control strategies were effective in reducing the acute hepatitis B notification rate. However, stronger prevention and control measures are needed in adult risk groups, particularly MSM.

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“…Chronic hepatitis B (HBV) is a relevant problem of public health all over the world [1][2][3] . This is due to the prevalence of hepatitis B virus in the world about 2 billion people are infected with it; there are over 500 million carriers of HBV, at 350 million.…”

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confidence: 99%

Features of Herd Immunity Against Hepatitis B (HBV) in the Territory of Republic of Sakha (Yakutia), Russian Federation

Savvin¹,

Reshetnikov²,

Barashkova³

et al. 2014

Biosci., Biotechnol. Res. Asia

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There is new data on the prevalence and characteristics of population immunity against HBV among the indigenous population of the Republic of Sakha (Yakutia) of the Russian Federation. HBV infection in the risk group is significantly higher than in the normal population, in patients with type 2 diabetes, there is a high parenteral infection of HBV, HCV and HBV + HCV (71,5%, 10,8% and 7,5% respectively). It was shown that every other 3-8 years among children and adults of Yakut population living in the Republic of Sakha (Yakutia) (hyperendemic region on HBV), vaccinated at birth against HBV, the frequency of detection of anti-HBs in protective concentrations (> 10 IU / l and higher) is-72.2%. Saving anti-HBs in vaccinated for 8 years indicates a high efficacy of vaccines against hepatitis B.

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Hepatitis B virus infection and vaccine-induced immunity in Madrid (Spain)

Abstract: Based on the prevalence of chronic infection (<1%), Madrid is a region with low HBV endemicity. Preventive strategies against HBV should especially target the immigrant population.

Cited by 6 publications

References 9 publications

Prevalence and risk factors of hepatitis B virus infection in Middle‐Limburg Belgium, year 2017: Importance of migration

Prevalence and risk factors of hepatitis B virus infection in Middle‐Limburg Belgium, year 2017: Importance of migration

Acute hepatitis B notification rates in Flanders, Belgium, 2009 to 2017

Features of Herd Immunity Against Hepatitis B (HBV) in the Territory of Republic of Sakha (Yakutia), Russian Federation

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