1991
DOI: 10.1002/hep.1840130607
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Hepatitis B virus infection in patients with idiopathic liver disease

Abstract: We studied 67 HBsAg‐negative Israeli patients (36 negative for all HBV serological markers as group 1 and 31 positive for antibodies to HBs and HBc as group 2) with chronic liver disease and cirrhosis of unknown origin using a rapid, sensitive and specific assay for the detection of low levels of hepatitis B virus in serum. This technique uses a high‐affinity monoclonal antibody to HBs against an a domain epitope of HBsAg to capture the virion, followed by hepatitis B virus DNA amplification with the polymeras… Show more

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Cited by 67 publications
(36 citation statements)
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“…Several reports indicate that occult HBV infection is associated with the progression of liver fibrosis and cirrhosis development also in patients with cryptogenic liver disease [18,48,[62][63][64]122,123,130]. This observation is not easy to explain, also in consideration of the abovementioned hypothesis that occult HBV might be unable to produce severe hepatic injury by itself.…”
Section: Occult Hbv Infection and Chronic Liver Diseasementioning
confidence: 71%
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“…Several reports indicate that occult HBV infection is associated with the progression of liver fibrosis and cirrhosis development also in patients with cryptogenic liver disease [18,48,[62][63][64]122,123,130]. This observation is not easy to explain, also in consideration of the abovementioned hypothesis that occult HBV might be unable to produce severe hepatic injury by itself.…”
Section: Occult Hbv Infection and Chronic Liver Diseasementioning
confidence: 71%
“…In fact, the studies evaluating the presence of occult HBV both in liver and in serum samples have shown that a relevant percentage of subjects who are negative for HBV DNA in the serum prove to be positive at liver tissue level [21,[48][49][50]. However, the fact that occult HBV carriers have very low viremia levels does not necessarily imply that the amount of viral genomes present in the liver is also very low.…”
Section: Virological Aspectsmentioning
confidence: 94%
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“…Reports of HBV genome detection have been published since 1990 with a frequency ranging from 4.8% to 72.7% [52]. The first studies performed in Europe, China and Israel, reported OBI in 55.5% [78], 60.7% [79] and 72.7% [80] of liver samples (frozen or paraffin-embedded tissues) obtained from patients negative for HBsAg.…”
Section: Discussionmentioning
confidence: 99%
“…These serobiologic conventions began to disintegrate when Brechot and others (reviewed in [8]) discovered hepatitis B virus (HBV) DNA in the serum or liver of patients negative for hepatitis B surface antigen (HBsAg) who lacked detectable antibodies to hepatitis B core antigen (antiHBc) and to HBsAg (anti-HBs). However, even when HBV was discovered in the liver and not in the serum [9], the sensitivity of the technology for detecting HBV DNA was questioned. Although completely negative seromarker test results for HCV-infected humans and chimpanzees have been observed transiently during follow-up, the causes of these rare events usually have been attributed to either collection, storage, and processing conditions;the varying sensitivity of the assays; or procedural testing errors.…”
mentioning
confidence: 97%