Hepatitis C: evaluation of outcomes and georeferencing of cases in Santa Cruz do Sul, Brazil, between 2002 and 2015. A cross-sectional study

Possuelo, Lia Gonçalves; Perin, Daiane; Breunig, Patricia Faber; Schroeder, Daniel Felipe; Allgayer, Manuela Filter; Darsie, Camilo; Carneiro, Marcelo; Hermes, Vanda; Renner, Jane Dagmar Pollo

doi:10.1590/1516-3180.2017.0169180917

Cited by 4 publications

(4 citation statements)

References 23 publications

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“…Although the distributions of HCV genotypes are well established in Brazil, they vary between regions and states. Even so, the predominance of genotype 1 over genotype 3 was also observed in several states, including Ceará, 15 Pernambuco, 16 Rio Grande do Sul, 17 , 18 Santa Catarina, 19 Amapá, Paraná, Rio de Janeiro, Rondônia and São Paulo, 17 in addition to states in the Midwest region. 17 , 20 …”

Section: Discussionmentioning

confidence: 94%

Hepatitis C virus genotypes and associated risk factors in the state of Pará, Northern Brazil

Castro

Amoras

Araújo

et al. 2020

The Brazilian Journal of Infectious Diseases

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Section: Discussionmentioning

confidence: 94%

Hepatitis C virus genotypes and associated risk factors in the state of Pará, Northern Brazil

Castro

Amoras

Araújo

et al. 2020

The Brazilian Journal of Infectious Diseases

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“…A partir da amostra analisada observou-se maior proporção de indivíduos do sexo masculino (58%), corroborando com os resultados encontrados por Hanus O grau de escolaridade de maior frequência correspondeu ao ensino fundamental incompleto, presente em 43% da amostra. Em um estudo transversal realizado por Possuelo et al (2018) no município de Santa Cruz do Sul-RS, demonstrou-se predominância do ensino fundamental completo/incompleto (67%), achado compatível com nossa pesquisa. Tabela 1: Dados sociodemográficos dos pacientes portadores de hepatite C admitidos na 20ª Regional de Saúde (n=137).…”

Section: Resultsunclassified

Caracterização clínica, geoprocessamento e perfil genotípico dos pacientes portadores de hepatite C admitidos na 20ª Regional de Saúde do Estado do Paraná

Ferronatto

Daronco

Rigon

et al. 2021

RSD

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A hepatite C é uma patologia de etiologia viral que compete como uma das principais causas de hepatopatia crônica a nível mundial. Globalmente, estima-se que em torno 80 milhões de pessoas são portadoras do vírus C da hepatite (HCV). No Brasil, os dados apontam que 2.5% a 4.9% da população está infectada pelo vírus. Objetivo: realizar a caracterização clínica, o geoprocessamento dos casos e identificar o perfil genotípico dos pacientes portadores de hepatite C admitidos pela 20ª Regional de Saúde do município de Toledo-PR, Brasil. Metodologia: estudo epidemiológico, retrospectivo e descritivo, tendo como fonte de coleta de dados os prontuários médicos e exames da 20ª Regional de Saúde do município de Toledo-PR, referente ao período de janeiro de 2015 a agosto de 2020. Resultados: dentre os 137 casos analisados, observou-se predominância de indivíduos do sexo masculino (58%), com entre 56 e 65 anos de idade (31%), de etnia autodeclarada branca (58%) e com ensino fundamental incompleto (43%). A hipertensão arterial sistêmica foi a comorbidade mais frequente (18%). Houve predominância do genótipo 1 (46%). Sofosbuvir+Daclatasvir+Ribavirina correspondeu ao esquema terapêutico mais utilizado (11%). F1 foi o grau de fibrose hepática mais comum (16%). Quanto à densidade de casos, o município de Toledo liderou com 46 portadores. Conclusão: as características sociodemográficas, clínicas e genotípicas dos pacientes portadores de hepatite C variam de acordo com a região geográfica e, portanto, a realização de estudos epidemiológicos deve ser estimulada.

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“…The South had the highest rate, which was greater than the national rate (9.3%). These findings may reflect the high degree of urbanization in the South and Southeast Regions of Brazil, which favours a greater prevalence of people who use injected drugs, which are an important source of hepatitis C and HIV infections [ 12 , 32 ]. In 2020, Nutini et al demonstrated a higher prevalence of HCV-HIV coinfection in the South Region of Brazil, where the mean age of coinfected individuals was lower than that of individuals who were monoinfected with HCV [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

A time series analysis of detection and mortality of hepatitis C in Brazil, 2008–2018

et al. 2022

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Background The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate hepatitis C virus (HCV) infection by 2030. In Brazil, efforts have been undertaken to achieve this goal; there are, however, great challenges. It is important to understand the disease profile in different regions of the country in order to design strategies to fight the disease nationwide. The objective of this study was to analyse the time trend of the incidence and mortality of hepatitis C in Brazil during the period from 2008 to 2018 according to sociodemographic and clinical characteristics. Methods All newly diagnosed cases of hepatitis C reported between 2008 and 2018, in all regions of Brazil, were included. The indicators were obtained from the databases of the Brazilian Ministry of Health. For the time series analysis, a joinpoint regression model was used. Results Between 2008 and 2018, 136,759 newly diagnosed cases of hepatitis C were reported considering anti-HCV and HCV RNA positivity, and 271,624 newly diagnosed cases were reported considering one or another positive test. The majority of the records were concentrated in the Southeast (61%) and South (26.2%) Regions. The joinpoint regression model indicated an increasing trend in the detection rate of hepatitis C in Brazil, but there was a decreasing trend in the mortality rate during the period analysed. Conclusions Differences were observed in the time trend of hepatitis C and in the sociodemographic and clinical characteristics in different regions of Brazil. These data can provide support to design strategies for the elimination of hepatitis C in Brazil, according to regional particularities.

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Hepatitis C: evaluation of outcomes and georeferencing of cases in Santa Cruz do Sul, Brazil, between 2002 and 2015. A cross-sectional study

Cited by 4 publications

References 23 publications

Hepatitis C virus genotypes and associated risk factors in the state of Pará, Northern Brazil

Hepatitis C virus genotypes and associated risk factors in the state of Pará, Northern Brazil

Caracterização clínica, geoprocessamento e perfil genotípico dos pacientes portadores de hepatite C admitidos na 20ª Regional de Saúde do Estado do Paraná

A time series analysis of detection and mortality of hepatitis C in Brazil, 2008–2018

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