Hepatitis C in pregnancy

Hunt, Christine M.; Carson, Kelly L.; Sharara, Ala I.

doi:10.1016/s0029-7844(97)81434-2

Cited by 60 publications

(24 citation statements)

References 82 publications

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“…HCV positivity has been reported in approximately 1-4% pregnant women [20] and vertical transmission has been estimated to approximate 5% of population [21]. WHO estimates rate of vertical transmission to be 3-15% in different populations and exclusively in HCV-RNA-PCR positive mothers [2].…”

Section: Discussionmentioning

confidence: 99%

Vertical transmission of hepatitis C virus in low to middle socio-economic pregnant population of Karachi

Aziz¹,

Hossain²,

Karim³

et al. 2010

Hepatol Int

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Purpose To determine the rate of vertical transmission (transmission from mother to child) of hepatitis C virus in low to middle socio-economic pregnant women. Methods This study was conducted at Sarwar Zuberi Liver Centre (SZLC) in collaboration with the department of Gynaecology and Obstetrics, Civil Hospital Karachi (CHK) and Abbasi Shaheed Hospital (ASH) for a period of 4 years from September 2005 to December 2009. Total 18,000 women seeking antenatal care were screened for hepatitis C antibodies (Anti-HCV) using 4th generation ELISA technique. Positive 1,043 women were further offered HCV ribonucleic acid (RNA) by polymerase chain reaction (PCR). Six hundred and forty women agreed to have PCR done, and 510 PCR positive women were finally included in the study, followed till delivery and treated if required. Newborns of 510 PCR positive mothers were advised HCV-RNA by PCR from 3 to 12 months of age and Anti-HCV at 18 up to 24 months and followed up to 3 years.Results 1,043/18,000 (5.79%) mothers were Anti-HCV positive, of which PCR results of 640 mothers are available where 510/640 (79.7%) were PCR positive, 357/510 (70%) delivered by spontaneous vaginal delivery (SVD), 33 (6.4%) by forceps delivery, 70 (13.7%) had elective, and 50 (9.8%) had emergency caesarian section. Premature rupture of membranes (PROM) was present in 81 mothers. Data of 510 babies from 3 months to 3 years of age was available of which only 215 had their laboratory tests done (HCV-RNA-PCR in 86 and Anti-HCV in 129). Mean birth weight (kg), height (cm) and OFC (cm) were 2.74 ± 0.43, 52.4 ± 7.5, and 35 ± 4. Apgar score median at 1 and 5 min was 7 (range 2-10), 8 (range 4-10), respectively. Low birth weight was present in 49 (9.6%), 37 (7.2%) had history of Neonatal Intensive Care Unit (NICU) admission. PCR of none of the 86 babies done at 3-12 months was positive. Five babies out of 129 were Anti-HCV positive at 18 months of age. Of this, 3/5 was HCV-RNA-PCR positive. Rate of vertical transmission of HCV was 1.39. Conclusion In spite of the high hepatitis C positivity in pregnant population, the rate of vertical transmission to the neonate is low.

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Section: Discussionmentioning

confidence: 99%

Vertical transmission of hepatitis C virus in low to middle socio-economic pregnant population of Karachi

Aziz¹,

Hossain²,

Karim³

et al. 2010

Hepatol Int

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“…Higher rates have been reported for both vertical transmission(18%,6-36%) and 41%) [83],and prevalence in children(15%) [84].Factors associated with an increased rate of infection include membrane rupture of longer than 6 hours before delivery and procedures exposing the infant to maternal blood [85]. Higher HCV infection has been reported in immunocompromised and those with human immunodeficiency virus infection, recipients of organ transplants, and those with hypogammaglobunemia.…”

Section: Hcv In Children and Pregnancymentioning

confidence: 99%

Management of Chronic Hepatitis C Virus Infection: Current Perspectives

Mustafa¹,

Menon²,

Illzam³

et al. 2016

IOSR

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“…Bei 60 bis 80% der Patienten wird die Erkrankung chronisch, bei der Hälfte entwickelt sich eine Leberzirrhose und bei ca. 10% nach 15 [2,3]. Ein erhöhtes Übertragungsrisiko eines bestimmten HCV-Genotyps konnte nicht gefunden werden [4,5].…”

Section: Allgemeinesunclassified

“…Ein sicherer Grenzwert ist jedoch aufgrund wechselnder Virämie nicht anzugeben [2,6,7,8,9,10]. ◗ Wenn die Mutter HCV-Antikörper-positiv (anti-HCV), aber HCV-RNA- [2,6,8]. ◗ Ein Neugeborenes, das HCV-RNApositiv ist, kann auch wieder negativ werden [8,9,11].…”

Section: Allgemeinesunclassified

Hepatitis C und Stillen

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2002

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschu

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Hepatitis C in pregnancy

Cited by 60 publications

References 82 publications

Vertical transmission of hepatitis C virus in low to middle socio-economic pregnant population of Karachi

Vertical transmission of hepatitis C virus in low to middle socio-economic pregnant population of Karachi

Management of Chronic Hepatitis C Virus Infection: Current Perspectives

Hepatitis C und Stillen

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