Hepatitis C: Prevalence of serologic markers and risk factors in blood donors at a large blood centre in South-eastern Brazil (2007–2010)

Mendes-Oliveira, Franciane; Bolina-Santos, Eduarda; Salomon, Tassila; Miranda, Carolina; Cioffi, Júnia Guimarães Mourão; Sabino, Éster Cerdeira; Barbosa-Stancioli, Edel Figueiredo; Moreno, Elizabeth Castro; Carneiro-Proietti, Anna Bárbara de Freitas

doi:10.1016/j.transci.2015.05.003

Cited by 7 publications

(4 citation statements)

References 16 publications

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“…In relation to gender, the prevalence of HCV infection in males and females has been controversial: some population‐based studies did not show any significant difference in prevalence between the two sexes [Gacche and Al‐Mohani, ], while others have shown a higher prevalence among females [Guadagnino et al, ; Maio et al, ; Di Stefano et al, ]. Other studies, similar to the present investigation, have shown a significantly higher prevalence of HCV infection among males [Tagnya et al, ; Keshvari et al, ; Mendes‐Oliveira et al, ]. These variations could be attributed to the type of study, the sample size, and the validity of the laboratory methods used for diagnosing anti‐HCV antibodies.…”

Section: Discussionsupporting

confidence: 50%

Hepatitis C virus infection in southwestern Saudi Arabia: Are we still in the plateau phase?

2016

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The aim was to study the seroprevalence of Hepatitis C virus (HCV) infection and related risk factors in Aseer region in southwestern Saudi Arabia, the region known to be of the highest endemicity of viral hepatitis. In a cross-sectional study, all participants were interviewed using structured questionnaire. HCV infection was diagnosed using fourth-generation ELISA. All positive and equivocal HCV serology results were further confirmed by using a qualitative confirmatory RT-PCR. The study enrolled 10,234 participants. A seroprevalence of 2.2% (95%CI: 1.9-2.5%) was found. In multivariate logistic regression analysis, the study showed that males had significantly more risk to become seropositive for HCV (aOR = 1.437, 95%CI: 1.071-1.927) compared to females. Similarly, participants having history of blood transfusion had more than two times the risk of becoming seropositive for HCV (aOR = 2.079, 95%CI: 1.037-4.149). HCV infection in the study area is still high in the plateau phase. It is recommended to have an active educational and media campaign about the risks of HCV infections. Workshops and training of qualified laboratory staff related to blood banking seem mandatory. J. Med. Virol. 89:867-871, 2017. © 2016 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 50%

Hepatitis C virus infection in southwestern Saudi Arabia: Are we still in the plateau phase?

2016

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“…When compared to other risk groups, the HCV prevalence found was higher than in Uberaba [24], Pará [25], Belo Horizonte [26] but similar to observed among prisoners in Central Brazil [27] and healthcare waste workers suggesting that this profession exposes the worker to the blood and other organic fluids and raises the risk of acquiring infections transmitted by parenteral pathways. The risk of HBV acquisition by dentist was already associated to the lack of vaccination [29].…”

Section: Discussionsupporting

confidence: 61%

Seroprevalence of Hepatitis B and Hepatitis C Virus Infections in Dentists From Belem, Para, Brazil

Costa¹,

Siravenha²,

Feitosa³

et al. 2018

BIOP

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“…At the same time, Brazilian blood banks have observed a decrease in the prevalence of transfusion-transmissible infections among donors, mainly HCV, likely attributed to the improvement in clinical and laboratory screening of hemotherapy services, as well as to changes in regional demographic composition. This ultimately reflects a decrease in the frequency of this infection in the community and, consequently, a reduction in the risk of blood transmission [23][24][25][26][27][28][29] . Our data indicating that HCV seroprevalence among HCT recipients is comparable to that of the, confirms the high quality and increased safety of blood transfusion in Brazil.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and clinical consequences of Hepatitis C virus infection in patients undergoing hematopoietic stem cell transplantation

Diaz,

Witkin,

Almeida Neto

et al. 2024

Rev. Inst. Med. trop. S. Paulo

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Hepatitis C virus (HCV) infection is a significant cause of morbidity and mortality among hematopoietic stem cell transplant (HCT) recipients. In Brazil, its occurrence in HCT recipients remains undetermined. We now report on HCV prevalence in HCT recipients and its clinical consequences. The medical records of all HCT recipients seen at Hospital das Clinicas, Sao Paulo University Medical School, from January 2010 to January 2020 were reviewed to determine HCV serostatus. A retrospective analysis of medical charts was undertaken on all seropositive cases to determine HCV genotype, presence of liver fibrosis, co-infections with other viruses, previous treatments, and clinical evolution of liver pathology after HCT. Of the 1,293 HCT recipients included in the study, seven (0.54%) were HCV antibody-positive and five (0.39%) were also viremic for HCV-RNA. Four of these individuals had moderate to severe liver fibrosis (METAVIR F2/F3) and one was cirrhotic. Two of the viremic patients developed acute liver dysfunction following transplantation. All patients had their acute episode of liver dysfunction resolved with no further complications. Four of the viremic patients were treated for HCV infection with direct acting agents (DAA). Information regarding HCV treatment was lacking for one of the viremic HCV patients due to loss of follow up. Sustained anti-virologic responses were observed in three cases after the use of DAA. The detection of HCV in hematological adults undergoing HCT and its successful treatment with DAA highlight the necessity of testing for HCV both prior to and following transplantation.

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Hepatitis C: Prevalence of serologic markers and risk factors in blood donors at a large blood centre in South-eastern Brazil (2007–2010)

Cited by 7 publications

References 16 publications

Hepatitis C virus infection in southwestern Saudi Arabia: Are we still in the plateau phase?

Hepatitis C virus infection in southwestern Saudi Arabia: Are we still in the plateau phase?

Seroprevalence of Hepatitis B and Hepatitis C Virus Infections in Dentists From Belem, Para, Brazil

Prevalence and clinical consequences of Hepatitis C virus infection in patients undergoing hematopoietic stem cell transplantation

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