Hepatitis C Virus and Lichen Planus

Liu, Sheng-yuan; Songpo, Yao; Wen, Wei; Tian, Weijun; Zhang, Haitao; Wang, Binyou

doi:10.1001/archdermatol.2009.200

Cited by 131 publications

(40 citation statements)

References 71 publications

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“…[21] The prevalence of hepatitis C in Indian population shows regional variation (Arunachal Pradesh 7.89%, Andhra Pradesh 1.4–2.02%, Maharashtra 0.09%, West Bengal 0.71%). [22] The overall prevalence of HCV in India is low compared to those countries which show correlation between these infections and OLP.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of hepatitis C and hepatitis B virus infection(s) in patients with oral lichen planus

Jayavelu

Sambandan

2012

J Pharm Bioall Sci

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Aim:The aim of this study was to determine the prevalence of hepatitis B virus and hepatitis C virus (HCV) infections in patients with oral lichen planus (OLP) and to compare it with that of general population.Materials and Methods:A total of 60 patients were included in the study. Patients were selected from the outpatient department of Rama Dental College Research Centre, Kanpur, Uttar Pradesh. Thirty patients with OLP were included in Group 1. Thirty age- and sex-matched healthy patients with no history of oral or skin lesions were included in Group 2. Detailed case history, biopsy (the most representative site of the lesion is chosen for specimen), detection of hepatitis B surface antigen (HBsAg), and detection of anti-HCV antibody were carried out.Results:The serum of the entire study sample (Group 1 and Group 2) was tested for both hepatitis C antibodies and HBsAgs with the enzyme-linked immunosorbent assay (ELISA) test (using the third generation kit). It was found negative for both HBsAgs and hepatitis C antibodies.Conclusion:In the present study, all the samples including OLP patients and healthy patients were seronegative for both hepatitis B (HBsAg) and hepatitis C (HCV antibody).

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Section: Discussionmentioning

confidence: 99%

Prevalence of hepatitis C and hepatitis B virus infection(s) in patients with oral lichen planus

Jayavelu

Sambandan

2012

J Pharm Bioall Sci

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“…Among them, a viral etiology has been suspected in view of the association with viral infections such as hepatitis C virus (HCV) and VZV [4,5,6,16]. In the literature of LP associated with VZV infection, LP followed the onset of HZ: they had LP lesions at healed HZ scars or at the site of a prior HZ eruption [4,5,6].…”

Section: Discussionmentioning

confidence: 99%

Detection of Varicella-Zoster Virus Antigens in Lesional Skin of Zosteriform Lichen Planus but Not in That of Linear Lichen Planus

Mizukawa

Horie²,

Yamazaki³

et al. 2012

Dermatology

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Background: Distinctions between ‘linear lichen planus’ (LP) and ‘zosteriform LP’ are difficult to determine solely based on clinical findings. Objective: The aim of this study is to determine whether the presence of the varicella-zoster virus (VZV) antigens could be used to differentiate the zosteriform LP from the linear LP. Methods: We immunohistochemically investigated the presence of in vivo localization of VZV antigens in 8 LP lesions (zosteriform LP: n = 5, linear LP: n = 3). Results: We describe 2 cases of zosteriform LP without apparent prior episodes of herpes zoster, in whom VZV antigens were detected in the eccrine epithelium. Further analysis showed that VZV antigens were exclusively detected in the eccrine epithelium in the zosteriform LP lesions, but not in the linear LP lesions. Conclusion: Etiological differences exist between zosteriform LP and linear LP. The presence of VZV antigens in lesional skin of the former indicates a possible triggering role of this virus in the pathogenesis of this variant.

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“…6 The role of hepatitis C virus in the development of lichen planus is an area of active investigation, with some theorizing that expression of viral antigens on the surface of the basal keratinocytes triggers a response by CD8 + T lymphocytes. 7 A recent meta-analysis found an association between hepatitis C virus infection and lichen planus, but this association was limited to certain geographic regions (East and Southeast Asia, South America, Middle East, and Europe). 7 These authors suggested that screening patients with lichen planus for occult hepatitis C infection may be warranted.…”

mentioning

confidence: 99%

“…7 A recent meta-analysis found an association between hepatitis C virus infection and lichen planus, but this association was limited to certain geographic regions (East and Southeast Asia, South America, Middle East, and Europe). 7 These authors suggested that screening patients with lichen planus for occult hepatitis C infection may be warranted. 7 …”

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confidence: 99%

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Allelic imbalance in oral lichen planus and assessment of its classification as a premalignant condition

Accurso¹,

Warner²,

Knobloch³

et al. 2011

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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OLP is a relatively common immune-mediated mucosal condition with a predilection for middle-aged women. Although classified as a premalignant condition, this classification remains controversial. Using stringent diagnostic criteria, some authors have found that OLP patients are not at increased risk for oral SCC. Credible but limited genetic evidence also indicates that epithelial tissues from OLP patients diagnosed using stringent criteria differs from premalignant or malignant oral lesions but is similar to epithelium from benign oral lesions. To further investigate this genetic line of evidence, biopsy specimens diagnosed as fibroma, OLP, low-grade dysplasia, high-grade dysplasia, and SCC were retrieved from the archives of the Oral Pathology Consultants at the Ohio State University. Using laser capture microdissection, tissue of interest was captured from each case and DNA subsequently extracted. Fluorescently labeled PCR primers were used to amplify DNA at 3 tumor suppressor gene loci (3p14.2, 9p21, and 17p13) and evaluated for LOH or microsatellite instability (MSI). OLP was found to be significantly different from low-grade dysplasia, high-grade dysplasia, and SCC when LOH/MSI was found at more than 1 loci (P = .011, P = .032, P = .003), but not different from benign fibromas (P = .395). In agreement with previous studies, well-documented cases of OLP diagnosed using stringent criteria exhibit a genetic profile more similar to a benign or reactive process than a premalignant/malignant one. These findings do not support the classification of OLP as a premalignant condition.

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Hepatitis C Virus and Lichen Planus

Cited by 131 publications

References 71 publications

Prevalence of hepatitis C and hepatitis B virus infection(s) in patients with oral lichen planus

Prevalence of hepatitis C and hepatitis B virus infection(s) in patients with oral lichen planus

Detection of Varicella-Zoster Virus Antigens in Lesional Skin of Zosteriform Lichen Planus but Not in That of Linear Lichen Planus

Allelic imbalance in oral lichen planus and assessment of its classification as a premalignant condition

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