Hepatitis C virus (HCV) genotype analysis in apparently healthy anti‐ HCV‐positive Parisian blood donors

Stuyver, Lieven; Fretz, Catherine; Esquivel, Cosme Alvarado; Boudifa, A.; Jaulmes, Dominique; Azar, Nabih; Lunel, F.; Leroux‐Roels, Geert; Maertens, Geert

doi:10.1046/j.1537-2995.1996.36696269516.x

Cited by 15 publications

(8 citation statements)

References 39 publications

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“…The five main HCV genotypes were found among French blood donors as already reported [12]. We confirm that 1b is the most prevalent genotype among European donors [12]and patients [13], followed by 3a.…”

Section: Discussionsupporting

confidence: 88%

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Hepatitis C Virus: Routes of Infection and Genotypes in a Cohort of Anti-HCV-Positive French Blood Donors

Elghouzzi¹,

Bouchardeau²,

Pillonel³

et al. 2000

Vox Sanguinis

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Background: We evaluated and analysed risk factors of HCV-infected blood donors according to HCV genotypes in order to improve the transfusion policy and safety of blood supply. Materials and Methods: HCV-RNA was analysed in sera from 518 anti-HCV-positive blood donors, who were invited to medical consultation and interview as to risk factors by means of an extensive questionnaire. HCV genotyping was done on all samples positive for HCV-RNA. Results: Of the 518 sera, 399 (77%) were HCV-RNA positive, and 394 of 399 HCV genotypes were identified. Major genotypes were 1b (34.3%), 3a (24%), 1a (19.5%) and 2 (11.4%). Of the donors, 289 (55.8%) were interviewed regarding their risk behaviour: 27% were former intravenous drug users (IVDUs), 26% had been transfused, 8% had a history of invasive diagnostic procedures, and 13% a history of surgery. Among the 224 interviewed donors, genotypes 1a and 3a were mainly associated with IVDU (51 and 45% respectively) and genotype 1b, with transfusion and nosocomial infections (40 and 25%, respectively). Conclusion: In this population of anti-HCV-positive blood donors, nosocomial infection may be a route of HCV spread, but the main risk factor remains IVDU, particularly in young men. The transfusion policy will improve if predonation interviews of such young men are done with a specific and sensitive questionnaire.

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Section: Discussionsupporting

confidence: 88%

“…We confirm that 1b is the most prevalent genotype among European donors [12]and patients [13], followed by 3a. We also found that IVDU and a history of blood transfusion are the main routes of HCV transmission, as observed in French studies [14, 15]and in other European countries [16, 17].…”

Section: Discussionsupporting

confidence: 75%

Hepatitis C Virus: Routes of Infection and Genotypes in a Cohort of Anti-HCV-Positive French Blood Donors

Elghouzzi¹,

Bouchardeau²,

Pillonel³

et al. 2000

Vox Sanguinis

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“…We could determine the serotype of 55 (80.9%) of the 68 samples, which is comparable with some other studies reporting 81.2% and 83%, respectively [16,17]. Serotypes 1 and 3 were the most prevalent serotypes among the Belgian population, confirming another Belgian study [18] which enrolled fewer patients from Flanders, as well as other studies among the European population [19][20][21][22][23]. Although these studies established the genotype instead of the serotype, the results can be compared since results obtained through genotyping and serotyping carried out using SA1-6 show a good correlation [16,17,24].…”

Section: Discussionsupporting

confidence: 88%

Serotyping and Genotyping of Hepatitis C Virus in Belgium

Cock

Vranckx

2003

Infection

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“…Numerous genotype distribution studies dating back to 1995 showed genotype 1 to be the most predominant (41,56,57,(78)(79)(80)(81)(82)(83)(84)(85). In the largest and best sample of HCV genotypes, 1769 samples were collected from 26 referral centres; 57% of the sample was genotype 1, 9.3% genotype 2, 20.8% genotype 3, 8.9% genotype 4, 2.7% genotype 5, 0.2% genotype 6 and 0.9% mixed genotypes (57).…”

Section: Genotype Distributionmentioning

confidence: 99%

A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel

Cornberg

Razavi

Alberti

et al. 2011

Liver International

374

294

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Background and Aim: Decisions on public health issues are dependent on reliable epidemiological data. A comprehensive review of the literature was used to gather country-specific data on risk factors, prevalence, number of diagnosed individuals and genotype distribution of the hepatitis C virus (HCV) infection in selected European countries, Canada and Israel. Methodology: Data references were identified through indexed journals and non-indexed sources. In this work, 13 000 articles were reviewed and 860 were selected based on their relevance. Results: Differences in prevalence were explained by local and regional variances in transmission routes or different public health measures. The lowest HCV prevalence ( 0.5%) estimates were from northern European countries and the highest (Z3%) were from Romania and rural areas in Greece, Italy and Russia. The main risk for HCV transmission in countries with wellestablished HCV screening programmes and lower HCV prevalence was injection drug use, which was associated with younger age at the time of infection and a higher infection rate among males. In other regions, contaminated glass syringes and Keywords diagnosis -epidemiology -HCV -hepatitis C -incidence -mortality -prevalence Conclusion: Despite the eradication of transmission by blood products, HCV infection continues to be one of the leading blood-borne infections in the region.Chronic hepatitis C (CHC) is a major health burden in Europe. Recent data suggest that patients with CHC have a higher overall morbidity and mortality (1, 2). A significant portion of liver transplantation in Europe is attributable to cirrhosis and hepatocellular carcinoma because of CHC (3). The socioeconomic impact of hepatitis C virus (HCV) infection is tremendous. The incidence of complications of CHC will not decline over the next 10 years despite improved efficacy of antiviral therapy because most patients with CHC remain undiagnosed (4). Prevention of new infections, HCV screening and early treatment have the potential to reduce the overall morbidity and mortality. However, the cost-effectiveness of HCV screening may depend on the HCV prevalence (5). Decisions on public health issues such as HCV screening and prevention measures are dependent on reliable epidemiological data regarding HCV prevalence and transmission routes. The epidemiological status in Europe is continuously evolving and may vary significantly among the different regions throughout Europe (6). Thus, different countries may need different strategies to reduce the overall burden of HCV infection.Because epidemiological data are the basis for the development of preventive measures, we aimed to systematically identify, review and characterize HCV epidemiology throughout Europe. We included Canada and Israel in our analysis because their healthcare systems and the epidemiological situation are similar to many European countries. MethodsA comprehensive review of the literature was used to gather country-specific data on risk factors, prevalence, number of diagnosed...

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Hepatitis C virus (HCV) genotype analysis in apparently healthy anti‐ HCV‐positive Parisian blood donors

Cited by 15 publications

References 39 publications

Hepatitis C Virus: Routes of Infection and Genotypes in a Cohort of Anti-HCV-Positive French Blood Donors

Hepatitis C Virus: Routes of Infection and Genotypes in a Cohort of Anti-HCV-Positive French Blood Donors

Serotyping and Genotyping of Hepatitis C Virus in Belgium

A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel

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