Serotyping and Genotyping of Hepatitis C Virus in Belgium

Cock, L. De; Vranckx, R.

doi:10.1007/s15010-002-3001-5

Cited by 9 publications

(10 citation statements)

References 39 publications

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“…The HCV genotypes in the studied group were distributed as follows: genotype 3 was predominant (49%), followed by genotype 1 (38%), genotype 4 (9%) and genotype 2 (2%). This distribution is quite different compared to the genotype distribution of a general Belgian population, in which genotype 1 (54%) is more prevalent than genotype 3 (15%) [De Cock and Vranckx, 2003]. The predominance of genotype 1 and 3 in injecting drug users in the three regions of Belgium is in accordance with the findings of the Belgian study and other Western European studies [Mathei et al, 2005].…”

Section: Discussionsupporting

confidence: 72%

Distribution of hepatitis C virus genotypes among injecting drug users in contact with treatment centers in Belgium, 2004–2005

Micalessi

Gérard

Ameye

et al. 2008

Journal of Medical Virology

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The aim of this study was to determine the current prevalence of HCV genotypes in injecting drug users recruited at treatment centers all over Belgium, and to analyze if the distribution of genotypes was correlated with demographic characteristics, at-risk behaviors, and co-infection with other viruses. Therefore 147 anti-HCV-positive serum samples were selected for subsequent HCV RNA detection and genotyping. HCV RNA could be detected in 98 (67%) of the 147 serum samples. Genotype 1 (38%) and 3 (49%) were the most common genotypes followed by genotype 4 (9%) and genotype 2 (2%). One mixed infection (1%) was detected. The subtype could be determined in 80 cases: genotype 3a was the most prevalent (49%), followed by genotype 1a (16%) and genotype 1b (15%). No significant difference was found between the distribution of genotypes and the location of treatment centers, at-risk behaviors and co-infection with other viruses. Nevertheless, a slight variation over time could be identified (P = 0.06): one in two genotype 3 drug users started with their injecting drug use in the last 10 years (33% in the period 1995-1999 and 21% in the period > or =2000) compared to only one in four genotype 1 drug users (20% in the period 1995-1999 and 9% in the period > or =2000).

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Section: Discussionsupporting

confidence: 72%

Distribution of hepatitis C virus genotypes among injecting drug users in contact with treatment centers in Belgium, 2004–2005

Micalessi

Gérard

Ameye

et al. 2008

Journal of Medical Virology

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“…Genotype 3, more frequent in wp donors than in control groups, is often detected in intravenous drug users (IVDUs) 26‐29 . Our donors denied this possibility.…”

Section: Discussionmentioning

confidence: 66%

“…Genotype 3, more frequent in wp donors than in control groups, is often detected in intravenous drug users (IVDUs). [26][27][28][29] Our donors denied this possibility. In the study of Orton and coworkers, 12 in 29.2 percent of wp donors, recent history of IVDU was the source of infection.…”

Section: Discussionmentioning

confidence: 96%

The hepatitis C virus genotype and subtype frequency in hepatitis C virus RNA‐positive, hepatitis C virus antibody‐negative blood donors identified in the nucleic acid test screening program in Poland

et al. 2004

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“…4 This disparity has prompted suggestions that routine serotypic determination of HCV isolates is necessary for the effective management of HCV-infected patients. 5 Furthermore, variations in the epidemiological pattern of HCV transmission have been recognised globally, with suggestions that each requires a specific intervention programme. Thus, our understanding of the serotypic profile of HCV types in each community could facilitate patient management and appropriate intervention programmes.…”

Section: Introductionmentioning

confidence: 99%

Hepatitis C virus prevalence and serotypes associated with HIV in The Gambia

Mboto

Fielder²,

Davies-Russell³

et al. 2010

British Journal of Biomedical Science

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Hepatitis C virus (HCV) serotypes are important in the epidemiology and pathogenesis of HCV-related disease, but little is known of this connection in West Africa. Coinfection with human immunodeficiency virus (HIV) is associated with significant morbidity and mortality. This study aims to determine the prevalence of HCV and its serotypes associated with HIV in The Gambia. A total of 1500 individuals referred to the Royal Victoria Teaching Hospital for HIV serology between July and December, 2002 were screened for antibodies to HIV and subsequently for HCV, and seropositive samples were typed. This study shows HIV and HCV prevalence of 6.7% and 1.6%, respectively, with a co-infection rate of 0.6%. Serotype 2 showed the highest prevalence (58.1%), followed by serotype 1 (19.4%). Prevalence of HCV serotype 3 was 6.5% and five samples were untypeable. Co-infection of HIV-1 with HCV serotype 1 showed a prevalence of 44.4%, and with HCV serotype 2 of 33.3%. The findings support the evidence to suggest the West African subregion as the origin of HCV serotype 2. It also demonstrates the need for routine HCV screening of HIV-infected persons and blood donations, and calls for further studies to elucidate the sources of the HCV virus.

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Serotyping and Genotyping of Hepatitis C Virus in Belgium

Abstract: Our data showed a 96.0% correlation between the serotyping and genotyping assays. Genotypes 1 and 3 are the most prevalent types among Belgian patients. The data suggest that genotype 1 spread earlier than genotypes 2, 3 and 4. This corroborates previous European studies.

Cited by 9 publications

References 39 publications

Distribution of hepatitis C virus genotypes among injecting drug users in contact with treatment centers in Belgium, 2004–2005

Distribution of hepatitis C virus genotypes among injecting drug users in contact with treatment centers in Belgium, 2004–2005

The hepatitis C virus genotype and subtype frequency in hepatitis C virus RNA‐positive, hepatitis C virus antibody‐negative blood donors identified in the nucleic acid test screening program in Poland

Hepatitis C virus prevalence and serotypes associated with HIV in The Gambia

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