Hepatitis C Virus (HCV) Infection: Serum Rheumatoid Factor Activity and HCV Genotype Correlate With Cryoglobulin Clonality

Antonescu, Cristian; Mayerat, C.; Mantegani, A.; Frei, P. C.; Spertini, François; Tissot, Jean‐Daniel

doi:10.1182/blood.v92.9.3486

Cited by 13 publications

(5 citation statements)

References 12 publications

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“…However the maximum RF concentration in their samples was 47 IU/ml, considerably lower than in other studies. Since RF seroprevalence is associated with viral, parasitic and chronic bacterial infections [ 8 , 14 , 15 ], the higher FP rates may be a concern in many malaria endemic countries, especially countries with high prevalence of hepatitis B and C [ 7 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

An assessment of false positive rates for malaria rapid diagnostic tests caused by non-Plasmodium infectious agents and immunological factors

et al. 2018

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BackgroundMalaria rapid diagnostic tests (RDTs) can produce false positive (FP) results in patients with human African trypanosomiasis and rheumatoid factor (RF), but specificity against other infectious agents and immunological factors is largely unknown. Low diagnostic specificity caused by cross-reactivity may lead to over-estimates of the number of malaria cases and over-use of antimalarial drugs, at the cost of not diagnosing and treating the true underlying condition.MethodsData from the WHO Malaria RDT Product Testing Programme was analysed to assess FP rates of 221 RDTs against four infectious agents (Chagas, dengue, Leishmaniasis and Schistosomiasis) and four immunological factors (anti-nuclear antibody, human anti-mouse antibody (HAMA), RF and rapid plasma regain). Only RDTs with a FP rate against clean negative samples less than 10% were included. Paired t-tests were used to compare product-specific FP rates on clean negative samples and samples containing non-Plasmodium infectious agents and immunological factors.ResultsForty (18%) RDTs showed no FP results against any tested infectious agent or immunological factor. In the remaining RDTs significant and clinically relevant increases in FP rates were observed for samples containing HAMA and RF (P<0.001). There were significant correlations between product-matched FP rates for RF and HAMA on all RDT test bands (P<0.001), and FP rates for each infectious agent and immunological factor were also correlated between test bands of combination RDTs (P≤0.002).ConclusionsFalse positive results against non-Plasmodium infectious agents and immunological factors does not appear to be a universal property of malaria RDTs. However, since many malaria RDTs have elevated FP rates against HAMA and RF positive samples practitioners may need to consider the possibility of false positive results for malaria in patients with conditions that stimulate HAMA or RF.

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Section: Discussionmentioning

confidence: 99%

An assessment of false positive rates for malaria rapid diagnostic tests caused by non-Plasmodium infectious agents and immunological factors

et al. 2018

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“…Previous studies have demonstrated mutated V gene rearrangements in SS, mucosa‐associated lymphoid tissue lymphoma [22,23], cryoglobulinaemia [24,25] and possibly other diseases, suggesting an antigen‐driven local immune response. However, to our knowledge, few reports analysing Ig V gene of infiltrating IgG4‐producing plasma cells in IgG4‐related disease are available [26].…”

Section: Introductionmentioning

confidence: 99%

Clonal relationship between infiltrating immunoglobulin G4 (IgG4)-positive plasma cells in lacrimal glands and circulating IgG4-positive lymphocytes in Mikulicz's disease

Yamada

Kawano

Inoüe

et al. 2008

Clinical and Experimental Immunology

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“…Serum samples (1 mL) were then simultaneously exposed to increasing temperatures (4, 10, 15, 20 and 258C) in stabilised incubators for 4 days prior to serum centrifugation and cryoglobulin titration, performed as previously described. 7 There was a clear temperature-dependent cryoprecipitation, as depicted in Figure 1 (r 2 0/0.94, p 0/0.0064). At 48C, cryoprecipitate composition was as follows: IgG 0.066 g/L, IgM 0.13 g/L; IgA and rheumatoid factor were not detectable.…”

Section: Case Historymentioning

confidence: 81%

Prevention of cryoprecipitation during cardiopulmonary bypass in a patient with HIV-HCV co-infections

Fontana¹,

Ruchat²,

Horisberger³

et al. 2006

Perfusion

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Hepatitis C Virus (HCV) Infection: Serum Rheumatoid Factor Activity and HCV Genotype Correlate With Cryoglobulin Clonality

Cited by 13 publications

References 12 publications

An assessment of false positive rates for malaria rapid diagnostic tests caused by non-Plasmodium infectious agents and immunological factors

An assessment of false positive rates for malaria rapid diagnostic tests caused by non-Plasmodium infectious agents and immunological factors

Clonal relationship between infiltrating immunoglobulin G4 (IgG4)-positive plasma cells in lacrimal glands and circulating IgG4-positive lymphocytes in Mikulicz's disease

Prevention of cryoprecipitation during cardiopulmonary bypass in a patient with HIV-HCV co-infections

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