Hepatitis C virus in Asia: utility values based on the Short Form-36 questionnaire

Abstract

Utility data are important in Asia, where the need for health economic evaluations is growing. A literature review was conducted across international and local bibliographical databases in four languages to evaluate the utilities for chronic hepatitis C (CHC) patients in Asia. The results showed a lack of research on the humanistic burden of CHC in Asia. Using mapping, the estimated utilities for CHC patients in Asia ranged between 0.68 and 0.86. The utilities of CHC patients were lower than that of healthy controls, with the differences ranging between 0.032 and 0.261 units. On-treatment utility values declined by 0.07-0.13 units for subjects without sustained virological response and by 0.03-0.06 units for sustained virological response subjects. The results provide empirical data on utility values among CHC patients in Asia that can be used in future cost-effectiveness analysis or health technology assessment.

Cost‐effectiveness of strategy‐based approach to treatment of genotype 1 chronic hepatitis C

“…Other outcome measures such as the number of liver complications prevented and liver‐related deaths prevented were evaluated. Health utility scores were obtained from published literature (Table ) …”

“…Health utility scores were obtained from published literature (Table 1). 18,26,27,29,30 Retreatment. To reflect real-life scenario, patients who failed to achieve SVR in the treatment arm would be retreated with SOF/LDV or OBV/PTV/r-DSV+/ÀRBV for 12 weeks 4 in accordance with current American Association for the Study of Liver Disease guidelines.…”

Cost‐effectiveness of the highly effective direct‐acting antivirals in the treatment of chronic hepatitis C in Hong Kong

“…The Short Form‐36 questionnaire for health survey is one of the most commonly used tools to estimate the utility values (Table ). Two review articles on the utility values scored by Short Form‐36 healthy survey in both Asian and Western CHC patients were compared and analyzed for the modelling in this study …”

“…Two review articles on the utility values scored by Short Form-36 healthy survey in both Asian and Western CHC patients were compared and analyzed for the modelling in this study. 37,38 Model outcomes and statistical analysis. Health benefits were measured in quality-adjusted life-year (QALY) gained using local data.…”

Factors Associated With Longitudinal QOL Change in Patients With Chronic Liver Diseases

“…Sarcopenia can also result in health-related quality of life (QOL) decline and be linked to poor outcomes in CLD patients (4,(7)(8)(9). The most widely accepted evaluation tool for patient health-related QOL is the 36-Item Short Form Health Survey (SF-36, self-reported questionnaire) (10)(11)(12). On the other hand, body composition analysis can be suitable for the evaluation of nutritional status in routine clinical settings as it involves simple and minimally invasive procedures (13,14).…”