Hepatitis C virus infection in patients with acute hepatitis B

Rodrı́guez, Manuel; Ca, Navascués; Martínez, Alberto; Suárez, A. García; Ng, Sotorrío; Cimadevilla, R.; Linares, Antonio; Pérez, Ramón; Rodrigo, Luı́s

doi:10.1007/bf01710674

Cited by 11 publications

(4 citation statements)

References 21 publications

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“…Most of the reports on acute coinfection occur in the settings of intravenous drug use, accidental needle stick, and blood transfusion [17–19]. Acute coinfection can result in clearance of one or both viruses as described below, or can result in fulminant hepatitis or chronic coinfection.…”

Section: Natural History Of Hbv/hcv Coinfectionmentioning

confidence: 99%

“…In the setting of acute coinfection, spontaneous clearance of either or both viruses has been documented in the literature [17, 21–23]. Mimms et al [21] observed that patients with coinfection had lower alanine transaminase (ALT) levels, delayed HBsAg appearance, and decreased HBs antigenemia, suggesting HCV suppression of HBV.…”

Section: Natural History Of Hbv/hcv Coinfectionmentioning

confidence: 99%

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Current Concepts of HBV/HCV Coinfection: Coexistence, but Not Necessarily in Harmony

2010

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Hepatitis B and hepatitis C are important causes of chronic liver disease globally. Although HBV/ HCV coinfection is not uncommon, its epidemiology is poorly defined. Numerous studies provided evidence that coinfection accelerates liver disease progression and increases the risk of hepatocellular carcinoma. By applying new cell culture models to examine the interaction of both viruses, investigators concluded that HBV and HCV replicate in the same hepatocyte without interference. The roles of innate and adaptive immunity in determining the viral replication and disease outcomes still need rigorous investigation. To date, no standard-of-care recommendation exists for HBV/HCV coinfection. Pegylated interferon and ribavirin combination therapy demonstrated similar efficacy in suppressing HCV RNA in coinfection and HCV monoinfection. However, HBV reactivation during therapy can be a challenge. Future clinical trials evaluating the addition of a nucleoside/nucleotide analog for selective patients with HBV/HCV coinfection are essential for successful management of HBV/HCV coinfection.

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Section: Natural History Of Hbv/hcv Coinfectionmentioning

confidence: 99%

Section: Natural History Of Hbv/hcv Coinfectionmentioning

confidence: 99%

Current Concepts of HBV/HCV Coinfection: Coexistence, but Not Necessarily in Harmony

2010

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“…A cute coinfection of hepatitis B virus (HBV) and hepatitis C virus (HCV) is rare but more prevalent in intravenous drug abusers (1). The few previous cases all describe acute HBV followed by acute HCV, leading to HBV clearance but chronic HCV (1)(2)(3)(4).…”

mentioning

confidence: 99%

Acute Coinfection with Hepatitis B and Hepatitis C Viruses

Yan

Lee

2005

Canadian Journal of Gastroenterology

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“…Indeed, concurrent infection with both HBV and HCV is growingly recognized in patients with acute and chronic hepatitis [220][221][222][223] . It has been reported that 22% of patients with HBV infection are tested positive with HCV [224][225][226][227][228] .…”

Section: Discussionmentioning

confidence: 99%

Electrochemical paper-based immunosensor for biomarkers detection

Boonkaew¹

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This dissertation focused on the development of electrochemical paper-based immunosensor for determining essential biomarkers by using a label-free immunoassay. This dissertation can be divided into four main parts. In the first part, an origami paper-based analytical device (oPAD) was developed for c-reactive protein (CRP) detection. oPAD was designed to combine the preparation of immunosensor and detection step into a single device. A gold nanoparticle modified graphene screen-printed carbon electrode (AuNPs/G/SPCE) was utilized to enhance the sensitivity of the electrode. The developed sensor was successfully applied to determine CRP in a certified serum sample. For the second part, an electrochemical paper-based analytical device (ePAD) was created for simultaneous determination of three crucial cardiovascular disease (CVD) biomarkers including CRP, troponin I (cTnI), and procalcitonin (PCT). The proposed ePAD has multiple detection zones and multiple working electrodes, which could enable simultaneous three biomarkers in a single sample with high sensitivity and selectivity. For the third part, a simple and low-cost ePAD immunosensor for ferritin determination was reported. The ePAD was custom designed on the filter paper to successfully fabricate an immunosensor. The working electrode was first modified with graphene oxide (GO) using an inkjet-printing technique to enhance the reproducibility of the electrode. The ePAD was finally applied in a practical sample, giving results that are in agreement with the standard method. Lastly, an ePAD was architecturally designed for simultaneous detection of hepatitis B (HBV) and hepatitis C core antigen (HCV). The fast-flow and delayed channels were created to control the flow velocity on an ePAD device. To validate the sensor performance, the developed immunosensor was applied to measure the known amount of HBV and HCV in the serum samples. All developed immunosensors provided good performances for biological and clinical diagnosis and allowed for further development of an advanced platform.

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Hepatitis C virus infection in patients with acute hepatitis B

Cited by 11 publications

References 21 publications

Current Concepts of HBV/HCV Coinfection: Coexistence, but Not Necessarily in Harmony

Current Concepts of HBV/HCV Coinfection: Coexistence, but Not Necessarily in Harmony

Acute Coinfection with Hepatitis B and Hepatitis C Viruses

Electrochemical paper-based immunosensor for biomarkers detection

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