Hepatitis C Virus Infection in Hemodialysis Patients: Comparison of the Surabaya Dialysis Center and Juntendo University Hospital Dialysis Centre

Santoso, Djoko; Pranawa, Pranawa; Yogiantoro, M; Widodo, Widodo; Wardana, Aditia; Mardiana, Nunuk; Mohani, Chandra Irwanadi; soewanto, soewanto; Shou, Ichiyu; Maeda, Kunimi; Hamada, Chikuma; Fukui, Mitsumine; Horikoshi, Satoshi; Tomino, Yasuhiko

doi:10.20473/ijtid.v1i3.2183

Cited by 4 publications

(4 citation statements)

References 20 publications

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“…Unfortunately, blood transfusion, rather than erythropoietin treatment, is still being used to correct renal anemia in the hemodialysis unit. Consistent with previous studies [Saketi et al, ; Santoso et al, ], the duration of hemodialysis was independently and positively associated with the prevalence of HCV infection, supporting the hypothesis that nosocomial transmission was responsible for HCV infection within the hemodialysis unit.…”

Section: Discussionsupporting

confidence: 91%

“…The prevalence of HBV infection in this study was higher than that in another hemodialysis unit in Jakarta, but the prevalence of HCV infection was lower than that in hemodialysis units in Jakarta and Surabaya, where the prevalence rates were 97.9% and 88%, respectively [Budihusodo et al, ; Santoso et al, ]. However, these findings may simply represent the high prevalence of HBV and HCV in Java, independent of hemodialysis units.…”

Section: Discussioncontrasting

confidence: 51%

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Hepatitis B and C virus infection among hemodialysis patients in yogyakarta, Indonesia: Prevalence and molecular evidence for nosocomial transmission

Rinonce

Yano

Utsumi

et al. 2013

Journal of Medical Virology

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Hemodialysis patients are at an increased risk of acquiring hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. However, the prevalence of hepatitis viral infection and its genotype distribution among hemodialysis patients in Indonesia are unclear. In order to investigate these issues and the possibility of nosocomial transmission, 161 hemodialysis patients and 35 staff members at one of the hemodialysis unit in Yogyakarta, Indonesia, were tested for serological and virological markers of both viruses. HBV surface antigen (HBsAg) was detected in 18 patients (11.2%) and in two staff members (5.7%). Anti-HCV was detected in 130 patients (80.7%) but not in any staff members. Occult HBV and HCV infection were detected in 21 (14.7%) and 4 (12.9%) patients, respectively. The overall prevalence rates of HBV and HCV infection among patients were 24.2% and 83.2%, respectively. HCV infection was independently associated with hemodialysis duration and the number of blood transfusions. Phylogenetic analysis revealed that 23 of 39 tested HBV strains (59%) were genotype B, 11 (28.2%) were genotype C, and 5 (12.8%) were genotype A. HCV genotype 1a was dominant (95%) among 100 tested HCV strains. Nosocomial transmission was suspected because the genotype distribution differed from that of the general population in Indonesia, and because the viral genomes of several strains were identical. These findings suggest that HBV and HCV infection is common among hemodialysis patients in Yogyakarta, and probably occurs through nosocomial infection. Implementation of strict infection-control programs is necessary in hemodialysis units in Indonesia.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 51%

Hepatitis B and C virus infection among hemodialysis patients in yogyakarta, Indonesia: Prevalence and molecular evidence for nosocomial transmission

Rinonce

Yano

Utsumi

et al. 2013

Journal of Medical Virology

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“…This figure is higher than the reported HCV seropositivity among the general population in Indonesia (1%) [ 13 ]. The seroconversion rate in our study was lower than the seroconversion rates reported from other hemodialysis units in Indonesia, that is, 38% in Jakarta and 88% in Surabaya [ 17 , 18 ]. Hepatitis C seroconversion in our dialysis unit was also lower than the seropositivity reported in studies in Brazil (46.7%), Libya (34.9%), and Egypt (34.8%) [ 8 , 19 , 20 ].…”

Section: Discussioncontrasting

confidence: 87%

“…Previous studies that investigated local HCV infection outbreaks within dialysis units found common evidence that suggests nosocomial infection with various risk factors related to the dialysis procedure, which were unique to each dialysis unit [2,15]. Accordingly, the duration of hemodialysis was reported as an independent risk factor for HCV transmission [2,[16][17][18]. Hemodialysis patients with hepatitis B and HIV infection also have a greater risk of HCV seroconversion [2].…”

Section: Introductionmentioning

confidence: 99%

Hepatitis C Seroconversion Remains High among Patients with Regular Hemodialysis: Study of Associated Risk Factors

Dharmesti

Wibawa

Kandarini

2022

International Journal of Hepatology

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Background/Aims. Hemodialysis patients have a higher risk of hepatitis C compared to the general population. The burden of hepatitis C infection among hemodialysis patients is substantial and was estimated to rise constantly. This study is aimed at determining the frequency of HCV seroconversion and associated risk factors among hemodialysis patients in our unit. Methods. An analytical cross-sectional study involving patients from 2 dialysis units (1 referral hospital and 1 private dialysis unit) in Denpasar, Bali, Indonesia, from January 2020 to December 2021. We evaluated age, gender, duration of hemodialysis, vascular access, history of transfusion, history of surgery, diabetes mellitus, hepatitis B, human immunodeficiency virus (HIV) infection, and type of dialyzer as possible risk factors of hepatitis C seroconversion among hemodialysis patients. Results. A total of 338 hemodialysis patients were enrolled in this study. We found hepatitis C seroconversion in 94 patients (27.8%), all of which occurred after regular dialysis was started. Vascular access type (OR 42.07, 95% CI 5.757–307.472) and dialyzer reuse (OR 8.324, 95% CI 4.319–16.044) were showing a statistically significant association with hepatitis C seroconversion. A separate analysis on each dialysis unit found common evidence that the duration of dialysis was significantly associated with hepatitis C infection among hemodialysis patients. Conclusion. Hepatitis C seroconversion among dialysis patients remains high. Factors related to the dialysis procedure itself played a major role in transmitting the virus.

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Current hepatitis B virus infection situation in Indonesia and its genetic diversity

Lusida¹,

Juniastuti²,

Yano³

2016

WJG

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Indonesia has a moderate to high endemicity of hepatitis B virus (HBV) infection. The risk for chronic HBV infection is highest among those infected during infancy. Since 1997, hepatitis B (HepB) vaccination of newborns has been fully integrated into the National Immunization Program. Although HBV infection has been reduced by the universal newborn HepB immunization program, it continues to occur in Indonesia. The low birth dose coverage and the presence of vaccine escape mutants might contribute to this endemicity among children. Although limited information is available for an analysis of occult HBV infection (OBI), several variations and substitutions in the pre-S/S region have been detected in Indonesian HBV strains. Additionally, persistent infection and disease progression of chronic hepatitis B are related to not only viral factors but also the host genome. Indonesia is one of the most ethnically heterogeneous nations, with Javanese and Sundanese as the two highest ethnic groups. This multi-ethnicity makes genomic research in Indonesia difficult. In this article, we focused on and reviewed the following aspects: the current hepatitis B immunization program and its efficacy, OBI, HBV infection among high-risk patients, such as hemodialysis patients, and research regarding the host genome in Indonesia.

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Hepatitis C Virus Infection in Hemodialysis Patients: Comparison of the Surabaya Dialysis Center and Juntendo University Hospital Dialysis Centre

Cited by 4 publications

References 20 publications

Hepatitis B and C virus infection among hemodialysis patients in yogyakarta, Indonesia: Prevalence and molecular evidence for nosocomial transmission

Hepatitis B and C virus infection among hemodialysis patients in yogyakarta, Indonesia: Prevalence and molecular evidence for nosocomial transmission

Hepatitis C Seroconversion Remains High among Patients with Regular Hemodialysis: Study of Associated Risk Factors

Current hepatitis B virus infection situation in Indonesia and its genetic diversity

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