Hepatitis Due to Aflatoxicosis

Krishnamachari, K. A. V. R.; Nagarajan, V.; Bhat, R. V.; Tilak, T. B. G.

doi:10.1016/s0140-6736(75)91829-2

Cited by 331 publications

(63 citation statements)

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“…Since 1982, deaths caused by AF-contaminated maize have repeatedly occurred in the Eastern Province of Kenya (Probst et al 2007). Similar cases have also previously been recorded at various times in India (Krishnamachari et al 1975) and Malaysia (Lye et al 1995). A recent case reported in Kenya is as a result of consuming contaminated maize (Nyikal et al 2004) with 125 deaths out of 317 cases (Azziz-Baumgartner et al, 2005) being recorded.…”

Section: Acute Toxicitysupporting

confidence: 72%

“…This condition is an inflammation of the liver cells caused by various agents including viruses e.g., hepatitis B virus, (HBV) and may be self healing or in extended chronic cases, lead to cirrhosis. Several cases of hepatitis have been reported in the literature including one in India that was attended by high mortality (Krishnamachari et al 1975). The outbreak was associated with maize contaminated by AF and it was concluded that it was as a result of aflatoxicosis.…”

Section: Hepatitismentioning

confidence: 99%

See 1 more Smart Citation

Aflatoxin Contamination in Foods and Feeds: A Special Focus on Africa

Anthony¹,

Francis²,

Berka³

et al. 2012

Trends in Vital Food and Control Engineering

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Section: Acute Toxicitysupporting

confidence: 72%

Section: Hepatitismentioning

confidence: 99%

Aflatoxin Contamination in Foods and Feeds: A Special Focus on Africa

Anthony¹,

Francis²,

Berka³

et al. 2012

Trends in Vital Food and Control Engineering

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“…Since the 1960s, aflatoxicosis epidemics have also been reported in India, Kenya and recently in Tanzania [3][4][5]. Management is a critical strategy for aflatoxin reduction.…”

Section: Introductionmentioning

confidence: 99%

Near Infrared Spectrometry for Rapid Non-Invasive Modelling of Aspergillus-Contaminated Maturing Kernels of Maize (Zea mays L.)

et al. 2017

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Aflatoxin-producing Aspergillus spp. produce carcinogenic metabolites that contaminate maize. Maize kernel absorbance patterns of near infrared (NIR) wavelengths (800-2600 nm) were used to non-invasively identify kernels of milk-, dough-and dent-stage maturities with four doses of Aspergillus sp. contamination. Near infrared spectrometry (NIRS) spectral data was pre-processed using first derivative Savitzky-Golay (1d-SG) transformation and multiplicative scatter correction on spectral data. Contaminated kernels had higher absorbance between 800-1134 nm, while uninoculated samples had higher absorbance above 1400 nm. Dose and maturity clusters seen in Principal Component Analysis (PCA) score plots were due to bond stretches of combination bands, CH and C=O functional groups within grain macromolecules. The regression model at 2198 nm separated uninoculated and inoculated kernels (p < 0.0001, R 2 = 0.88, root mean square error = 0.15). Non-invasive identification of Aspergillus-contaminated maize kernels using NIR spectrometry was demonstrated in kernels of different maturities.

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“…Another outbreak of acute aflatoxicosis in India in 1974 practically spared the children under the age of five years, who made about 8 % of the affected patients (13,14). In the most severe aflatoxicosis outbreak in Kenya in 1981, the number of affected children was never established (15), but in the outbreak of 2004, it was half of those whose age data was known (308 of 317 people).…”

Section: Aflatoxinsmentioning

confidence: 99%

Mycotoxicoses in children

Peraica

Richter

Rašić

2014

Archives of Industrial Hygiene and Toxicology

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Mycotoxicoses are acute and chronic poisonings caused by mould toxins called mycotoxins. Although acute mycotoxicoses, caused by high mycotoxin levels in food are rare nowadays, they need to be described in order to inform physicians and other health care workers about their symptoms. Children are more sensitive to mycotoxins because of their lower body mass, higher metabolic rate, and underdeveloped organ functions and detoxication mechanisms. Some mycotoxicoses appear only in children, and some are more pronounced in children than in adults. Acute mycotoxicoses in children are reported poorly, mostly because they occur in the tropical regions with poor healthcare coverage. In developed countries healthcare authorities are more concerned about child exposure to low levels of mycotoxins with immunotoxic, genotoxic or carcinogenic properties.

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Hepatitis Due to Aflatoxicosis

Cited by 331 publications

References 1 publication

Aflatoxin Contamination in Foods and Feeds: A Special Focus on Africa

Aflatoxin Contamination in Foods and Feeds: A Special Focus on Africa

Near Infrared Spectrometry for Rapid Non-Invasive Modelling of Aspergillus-Contaminated Maturing Kernels of Maize (Zea mays L.)

Mycotoxicoses in children

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