Hepatitis E virus in the countries of the Middle East and North Africa region: an awareness of an infectious threat to blood safety

Yazbek, Soha; Kreidieh, Khalil; Ramia, S.

doi:10.1007/s15010-015-0807-5

Cited by 30 publications

(34 citation statements)

References 115 publications

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“…A recent review reported that the anti-HEV seroprevalence in the general population in countries of the Middle East and the Northern African-region, where also Morocco is situated, ranges from 2 to 38 % [24]. This is lower than the 44 % weighted prevalence that we found among first generation Moroccans in Amsterdam.…”

Section: Discussioncontrasting

confidence: 76%

Seroprevalence of hepatitis E virus differs in Dutch and first generation migrant populations in Amsterdam, the Netherlands: a cross-sectional study

et al. 2016

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BackgroundIn the last decade hepatitis E virus (HEV) is increasingly recognized as a cause of acute viral hepatitis in developed countries. HEV is transmitted via the fecal-oral route. In countries like the Netherlands, HEV infection is suspected to be a zoonosis but HEV may also be introduced by migrants. We studied the seroprevalence of HEV among different migrants, mainly Moroccans and Turks, and compared this to that of the native Dutch population in Amsterdam, the Netherlands.MethodsData were obtained from a cross-sectional survey of the adult Amsterdam population performed in 2004; the Amsterdam Health Monitor. A total of 1199 plasma samples were tested for IgG-and IgM antibodies to HEV using the Wantai kit according to instructions of the manufacturer. Basic demographic data (gender, age, country of birth, and age at immigration) were used in the analyses. Hepatitis A virus (HAV) serology data were available from a previous study.ResultsThe total weighted anti-HEV IgG seroprevalence in the overall Amsterdam population was 26.7 %, based on 1199 samples. In the study population (not-weighted) this HEV seroprevalence was 157/426 (36.9 %) for the Dutch participants and it was 161/257 (62.6 %) for Moroccans, 99/296 (33.4 %) for Turks and 42/220 (19.1 %) for other ethnicities. HEV seroprevalence increased significantly with age. First-generation Moroccan migrants (44.0 %) had a significantly higher weighted HEV seroprevalence than the Dutch participants (29.7 %). In the first generation Turks (20.3 %) and first generation migrants from other countries (16.7 %) this weighted seroprevalence was lower, but this was only significant for the ‘other ethnicities’. The median age of migration was significantly higher in the Moroccan and Turkish migrants who were HEV IgG positive versus HEV IgG negative. However, when stratifying for age at time of study, median migration age was only significantly different for HEV sero-status for younger Turks and younger ‘other ethnicities’. HEV IgM antibodies were found in 0.6 % (n = 7) of participants and none were positive for HEV RNA, showing that there were no acute infections. Despite the common route of fecal-oral transmission for both viruses, there was no relation between HEV and HAV seropositivity.ConclusionWithin the multi-ethnical capital city of Amsterdam the HEV seroprevalence in first generation migrant populations differed from each other and from the autochthonous Dutch population. The relation between being HEV seropositive and a higher median age of migration suggests that younger migrants got more often infected in their country of origin than in the Netherlands.

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Section: Discussioncontrasting

confidence: 76%

Seroprevalence of hepatitis E virus differs in Dutch and first generation migrant populations in Amsterdam, the Netherlands: a cross-sectional study

et al. 2016

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“…Only two persons were found to have positive IgM for HEV. INFECTION has reported on the growing awareness of HEV not only in special risk populations but also in the area of transfusion services [10].…”

Section: The European Congress Of Clinical Microbiology and Infectioumentioning

confidence: 99%

Scaring and encouraging news on diagnosis, spreading, and therapy of resistant organisms: the ECCMID 2017 in Vienna

Bogner

2017

Infection

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“…It has been reported that a slow shift in the age of infected subjects from childhood to adulthood has been observed (14). The hepatitis D virus (HDV) appears to be endemic in the ME region (15), and the hepatitis E virus is reported to have a prevalence ranging from 2.0% to 37.5% in countries of the ME and North Africa (16). Furthermore, other types of hepatitis, including non-viral (autoimmune and drug-induced) hepatitis, have been reported in the region of the ME (17,18).…”

Section: Introductionmentioning

confidence: 99%

Ten-year analysis of hepatitis-related papers in the Middle East: a web of science-based scientometric study

Rezaee‐Zavareh¹,

Alavian

2017

Turk J Gastroenterol

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Hepatitis E virus in the countries of the Middle East and North Africa region: an awareness of an infectious threat to blood safety

Cited by 30 publications

References 115 publications

Seroprevalence of hepatitis E virus differs in Dutch and first generation migrant populations in Amsterdam, the Netherlands: a cross-sectional study

Seroprevalence of hepatitis E virus differs in Dutch and first generation migrant populations in Amsterdam, the Netherlands: a cross-sectional study

Scaring and encouraging news on diagnosis, spreading, and therapy of resistant organisms: the ECCMID 2017 in Vienna

Ten-year analysis of hepatitis-related papers in the Middle East: a web of science-based scientometric study

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