Hepatitis in pre-school children: prevalent role of cytomegalovirus

Nigro, Giovanni; Mattia, S.; Vitolo, Rosa; Bartmann, U.; Midulla, M

doi:10.1007/978-3-7091-5633-9_60

Cited by 5 publications

(1 citation statement)

References 10 publications

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“…In an extensive review of the medical literature, we found descriptions of 34 cases of severe CMV disease in immunocompetent adults [6] and only six cases in immunocompetent children [5,7]. Of these six children, five were aged 1-5 years and one was aged 8 months.…”

Section: Discussionmentioning

confidence: 99%

Ganciclovir for Severe Cytomegalovirus Primary Infection in an Immunocompetent Child

Hadaya

Kaiser

Rubbia‐Brandt

et al. 2004

European Journal of Clinical Microbiology & Infectious Dise

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Described here is the unusual case of a previously healthy 17-month-old girl who developed severe cytomegalovirus (CMV) disease with prolonged fever and hepatitis. The severity of her illness required hospitalization and prompted antiviral treatment. Short-term intravenous ganciclovir treatment was associated with immediate and sustained resolution of the symptoms as well as a sharp decrease of CMV viremia. This observation suggests that antiviral therapy might be considered in select cases of severe primary CMV infection in immunocompetent children.

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Section: Discussionmentioning

confidence: 99%

Ganciclovir for Severe Cytomegalovirus Primary Infection in an Immunocompetent Child

Hadaya

Kaiser

Rubbia‐Brandt

et al. 2004

European Journal of Clinical Microbiology & Infectious Dise

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Multiple viral infections in HIV-infected children with chronically-evolving hepatitis

Nigro

Taliani

Krzysztofiak

et al. 1993

Research in Chronic Viral Hepatitis

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Ganciclovir therapy for cytomegalovirus-associated liver disease in immunocompetent or immunocompromised children

et al. 1997

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Ganciclovir therapy was given intravenously to 20 children with cytomegalovirus (CMV)-associated liver disease, of whom 6 were immunocompetent and 14 were immunocompromised (9 had AIDS and 5 had solid tumors). Immunocompetent children had isolated liver disease diagnosed at birth (4 children), or systemic congenital CMV infection including liver disease (2 children). Ganciclovir was used following two regimens: A) 5 mg/kg twice daily for 8 to 86 days (mean 21); B) 7.5 mg/kg twice daily for 14 days followed by 10 mg/kg three times weekly for three months. CMV infection was diagnosed by viral isolation, detection of viral antigens, and/or CMV DNA from blood and urine. All immunocompetent children had negative CMV culture and CMV DNA detection from blood and/or urine after 14 weeks of treatment. However, the three children who were treated with regimen B showed normal ALT levels at the end of the maintenance course, whereas the children who received ganciclovir with regimen A had normal ALT levels only after about 1 year. All children with tumors initiated regimen B, but only three, who had negative CMV detection and markedly decreased ALT levels, received full treatment; of the remaining two children, one recovered after only an initial course, and the other had therapy interrupted because of hepatic failure and died 9 days later. In contrast, the children with AIDS received several ganciclovir courses for different periods at the lower dosage: they generally improved during treatment but did not recover completely, and five children died with active CMV infections. Based on our study, CMV-associated liver disease can be efficiently treated with ganciclovir both in immunocompetent and immunodeficient children. However, a single ganciclovir course including a higher dosage and prolonged therapy appeared to be more effective than several courses with lower dosages.

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Hepatitis in pre-school children: prevalent role of cytomegalovirus

Cited by 5 publications

References 10 publications

Ganciclovir for Severe Cytomegalovirus Primary Infection in an Immunocompetent Child

Ganciclovir for Severe Cytomegalovirus Primary Infection in an Immunocompetent Child

Multiple viral infections in HIV-infected children with chronically-evolving hepatitis

Ganciclovir therapy for cytomegalovirus-associated liver disease in immunocompetent or immunocompromised children

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