2019
DOI: 10.21037/hbsn.2019.03.06
|View full text |Cite
|
Sign up to set email alerts
|

Hepatobiliary surgeons meet immunologists: the case of colorectal liver metastases patients

Abstract: The burgeoning field of cancer immunology demands a change in the paradigm of cancer patient management. The understanding of the course of a given malignant disease should also include the host immune system as one of the key factors in determining the patient's prognosis. Surgical and medical oncologists need to understand the basic and advanced applications of immunotherapies, which are rapidly evolving, and are nowadays an integral part of the armamentarium for the treatment of cancer patients. In the pres… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
4

Relationship

1
3

Authors

Journals

citations
Cited by 4 publications
(2 citation statements)
references
References 60 publications
0
2
0
Order By: Relevance
“…Moreover, scRNA-seq uncovered malignancy-associated exhausted and regulatory T cells, together with a subset of dendritic cells (DC3), as players involved in CLM development [181]. Therefore, the host immune system represents one of the key factors in determining the patient's prognosis, and its involvement in the study of new effective immunotherapies is rapidly evolving [182]. Nowadays, curative tumor resection and chemotherapy are the standard methods of treatment in patients with CLMs [183].…”
Section: Senescence In Colorectal Liver Metastases (Clm)mentioning
confidence: 99%
“…Moreover, scRNA-seq uncovered malignancy-associated exhausted and regulatory T cells, together with a subset of dendritic cells (DC3), as players involved in CLM development [181]. Therefore, the host immune system represents one of the key factors in determining the patient's prognosis, and its involvement in the study of new effective immunotherapies is rapidly evolving [182]. Nowadays, curative tumor resection and chemotherapy are the standard methods of treatment in patients with CLMs [183].…”
Section: Senescence In Colorectal Liver Metastases (Clm)mentioning
confidence: 99%
“…2 Considering that the liver is the main filter for intestinal venous drainage, CRC patients often develop colorectal liver metastases (CLM). 3 Synchronous CLM occurs in approximately 15% of patients at the initiation of therapy, and approximately 50% of patients during follow-up. 4 Surgical resection is the standard treatment for patients with limited disease CLM, but most patients are not suitable for surgery because of extensive disease, tumor multiplicities, concomitant major systemic diseases, or poor hepatic functional reserve.…”
Section: Introductionmentioning
confidence: 99%