Hepatocarcinogenicity of Glandless Cottonseeds and Cottonseed Oil to Rainbow Trout (
            <i>Salmo gairdnerii</i>
            )

Hendricks, Jerry D.; Sinnhuber, R. O.; Loveland, Patricia M.; Pawlowski, Norman E.; Nixon, J.E.

doi:10.1126/science.6892734

Cited by 55 publications

(38 citation statements)

References 19 publications

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“…O resultado do estudo dos ácidos graxos da Sterculia striata reforça o relatado na literatura sobre a presença de compostos com grupos ciclopropênicos em óleos de sementes de plantas da família Sterculiaceae 6,7 . Desta forma, não se recomenda a ingestão das amên-doas de chichá e o óleo só será próprio para fins comestíveis se tais ácidos forem eliminados 4,9,24 . …”

Section: Resultsunclassified

Caracterização química do óleo da amêndoa de Sterculia striata St. Hil. et Naud

Chaves¹,

Barbosa²,

Neto³

et al. 2004

Quím. Nova

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Section: Resultsunclassified

Caracterização química do óleo da amêndoa de Sterculia striata St. Hil. et Naud

Chaves¹,

Barbosa²,

Neto³

et al. 2004

Quím. Nova

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“…Namely, Hendricks et al [6] failed to prove the presence of tumors on 144 necropsies in brown bullheads (Ictalurus nebulosus), but tumor incidence in the same type of fish taken from polluted waters ranged 30% on the sample of 532 [6] . Neoplasms do appear in all non-mammalian vertebrates and this is important in and of itself since these animals can serve as models to understand the behaviour and trajectory of such tumors in mammals and humans.…”

Section: Comparative Oncologymentioning

confidence: 99%

Comparative Oncology and Comparative Tumor Immunology

Bubanovic¹,

Najman²

2005

J. of Biological Sciences

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Abstract:Comparative oncology is a branch of comparative pathology that is relatively new biomedical discipline. The need for a comparative research into tumors across different groups of living beings has arisen from a relatively old notion that most of multicellular organisms may develop tumors. This apparently very simple fact indicate the possible nature of tumor growth, which can be associated with the basic features of the cells of multicellular organisms such as the division, development, growth and differentiation of cells and tissues. Regarding this, tumor growth is commonly defined as a fundamental disorder in the regulation of cell division, growth, differentiation and cell socialization. In all vertebrates, neoplasia is a disease in which genetically altered cells escape from the normal cell-cycle regulation and monitoring of the immune system. This results in a persistent, expanding or infiltrating growth without control and the architecture of the normal tissue. Concerning the facts that mechanisms of cell sociability control and anti-tumor immune monitoring might be different in different group of animals, especially, in different classes of vertebrates, development of disciplines such as comparative oncology and comparative tumor immunology can be of great scientific importance.

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“…Dietary CFAs caused lesions, increased glycogen deposition, and elevated saturated fatty acid concentration in the liver in rainbow trout (Struthers et al 1975a, b). The CFAs are powerful carcinogens when fed in combination with aflatoxins for rainbow trout (Hendricks et al 1980) and sockeye salmon (Wales and Sinnhuber 1972). These compounds also induced hepatomas without aflatoxins in rainbow trout (Hendricks et al 1980).…”

Section: Cyclopropenoic Fatty Acidsmentioning

confidence: 99%

“…The CFAs are powerful carcinogens when fed in combination with aflatoxins for rainbow trout (Hendricks et al 1980) and sockeye salmon (Wales and Sinnhuber 1972). These compounds also induced hepatomas without aflatoxins in rainbow trout (Hendricks et al 1980). Dietary CFAs alter the activity of several liver enzymes (Eisele et al 1983), including the inhibition of fatty acid desaturases (Roehm et al 1970) which may explain the accumulation of saturated fatty acids found in the liver of fish fed CFAs.…”

Section: Cyclopropenoic Fatty Acidsmentioning

confidence: 99%

Mini review on Incorporation of Cotton Seed Meal, an Alternative to Fish Meal in Aquaculture Feeds

Kumar¹,

Ramudu

Devi

2014

International Journal of Biological Research

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Fish nutrition has advanced dramatically in recent years with the development of new balanced commercial diets that promote best fish growth and health. Feed accounts for a major part (30-70%) of the total operation cost of an average fish farm. Traditionally, animal protein sources, particularly fishmeal have been the major ingredient of aqua feeds. Fishmeal is one of the most expensive ingredients in formulated fish feeds. Due to increasing demand, decreasing supply and the high cost of fish meal, fish nutritionists have concentrated their efforts to find alternative protein sources to substitute fish meal in the diet of fish. Thus, cottonseed meal (CSM), a by-product of the cotton fiber and cottonseed oil industries, may be used to replace fish meal partially or totally in fish diets. However, the cottonseed meal was evaluated by its anti-nutritional factors and its impact on the growth, survival, carcass composition and histopathology of fishes. It is observed that the more research is concentrated on the gossypol content in the cottonseed meal which is described as the antinutritional factor that shows high impact on the growth, carcass composition and pathological changes in the fish. Hence, considering these problems it is advised to use low levels of cottonseed meal in the aqua feeds. The gossypol level can be minimized by the solvent extracted cottonseed meal and be counteracted by the fortification of lysine and adding up of required iron levels. Further research may be required in histopathological studies to assess the toxicity levels in the tissues of the fish due to the gossypol factor.

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Hepatocarcinogenicity of Glandless Cottonseeds and Cottonseed Oil to Rainbow Trout ( Salmo gairdnerii )

Cited by 55 publications

References 19 publications

Caracterização química do óleo da amêndoa de Sterculia striata St. Hil. et Naud

Caracterização química do óleo da amêndoa de Sterculia striata St. Hil. et Naud

Comparative Oncology and Comparative Tumor Immunology

Mini review on Incorporation of Cotton Seed Meal, an Alternative to Fish Meal in Aquaculture Feeds

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