Hepatocellular Carcinoma After Renal Transplantation: The Long-Term Impact of Cirrhosis on Chronic Hepatitis B Virus Infection

Changes in peripheral lymphocyte subsets in patients after partial microwave ablation of the spleen for secondary splenomegaly and hypersplenism: A preliminary study

“…immune function of cirrhotic patients with secondary splenomegaly and hypersplenism is low. Patients easily contract infections and HCC [30,31]. Splenic immune function is important and removal of the spleen is not to be taken lightly.…”

Outcomes and risk factors for hepatitis B virus (HBV) reactivation after kidney transplantation in occult HBV carriers

“…Several reports have shown that HBsAg‐seropositive recipients are at high risk of developing liver function failure and HCC , and meta‐analysis has demonstrated that HBsAg seropositivity was an independent risk factors for patient death and graft failure . However, whether HBsAg‐seronegative but HBcAb‐seropositive occult HBV carriers have similar risks after kidney transplantation still needs to be evaluated.…”

Systematic review of hepatocellular carcinoma mortality rates among hepatitis B virus-infected renal transplant recipients, with supplemental analyses of liver failure and all-cause mortality

“…Two studies did not respond. The authors of Fan et al did not respond; 50 it was decided to include their study because antiviral therapy only became widely utilized in Taiwan in 2002 when a government funding program began, and their follow-up finished in 2004. Authors of a second study from India published in 2009 did not reply; the study was excluded.…”

“…The appearance of the term HCC in the title and/or abstract was considered indicative that the cases may have influenced the decision to publish. From high seroprevalence areas, only Fan et al 50 highlighted their cases of HCC mortality. Two additional studies were found that highlighted the cases of mortality from HCC.…”

“…However, inflammation is not completely inactivated in RT patients, and cirrhosis is well documented to develop in HBsAgseropositive RT patients. 10,33,50,95,108,109 Serum HBV DNA levels have recently become recognized as having very strong associations with mortality due to NMLD and HCC for in persons of the general population. 99 Serum HBV DNA levels are high in RT patients, 95,110,111 due to their reduced T-lymphocyte activity.…”