Hepatocellular carcinoma first presenting as a tumor of the oral cavity

Alrumaih, Redha Ali; Arian, A; Alhedyani, Alanoud A.; Al-Zaher, Nabil; Dababo, Mohammad Anas

doi:10.1016/j.hemonc.2015.03.001

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…Among this series and other published cases in Korean or Japanese languages, more patients were from Asian areas including Japan, China, Korea, and Indonesia [3, 7–18, 25–29]. It seems that Asia should be the specific region with highest morbidity rate of HCC-metastatic gingival tumor, which is probably attributed to the geographic epidemiological characteristic of HCC [11, 12, 17].…”

Section: Discussionmentioning

confidence: 67%

“…According to limited series with survival data in English literatures, the median time of overall and truncated survival for HCC patients with gingival metastasis is about 11.5 months (range, 2 to 92 months) and 3.5 months (range, 1 to 15 months), respectively (Table 1). Herein, many cases, which are individually reported or included in systematic reviews but without complete survival data or accurate description of gingival metastasis, have been excluded [4–6, 19, 29–31, 33–35]. A diagnosed case of gingival metastasis with synchronic HCC and primary prostate cancer has also been excluded because the survival may be markedly influenced by the second malignancy [36].…”

Section: Discussionmentioning

confidence: 99%

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Rare Gingival Metastasis by Hepatocellular Carcinoma

Xue

Mao

Geng

et al. 2017

Case Reports in Medicine

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Hepatocellular carcinoma (HCC) uncommonly metastasizes to the gingiva, which always means a poor outcome. We reported a rare HCC case with multiple metastases to gingiva, lungs, and brain. A 60-year-old man was initially diagnosed as HCC with metastases to double lungs. He was subjected to a transarterial chemoembolization (TACE) (5-fluorouracil, 750 mg) and two cycles of intravenous chemotherapy (gemcitabine 1.8 g at days 1 and 8, oxaliplatin 200 mg at day 2, every 4 weeks). However, the volume of liver tumor still increased. A bean-size gingival nodule growing with occasional bleeding was also found. TACE (5-fluorouracil 750 mg, perarubicin 40 mg, cisplatin 20 mg) was performed again and an oral sorafenib therapy (400 mg, twice per day) was adopted. The disease maintained relatively stable for about 6 months until a second obvious progress. The gingival nodule was then palliatively excised and identified as a poorly differentiated metastatic HCC by histopathological examination. Best supportive treatments were made since the performance score was too bad. Finally, cerebral metastases occurred and the patient died of systemic failure. Upon review of previous reports, we discussed risk factors, clinical and pathological characteristics, treatments, and prognosis of gingival metastasis by HCC.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Rare Gingival Metastasis by Hepatocellular Carcinoma

Xue

Mao

Geng

et al. 2017

Case Reports in Medicine

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“…Hepatocellular carcinoma (HCC) is considered the sixth most common malignant neoplasm in the world, with 748,000 cases per year [1]. Its etiology is associated with hepatitis A, hepatitis B, hepatitis C and alcohol consumption [2].…”

Section: Introductionmentioning

confidence: 99%

“…Its etiology is associated with hepatitis A, hepatitis B, hepatitis C and alcohol consumption [2]. Extra-hepatic metastases occur in 50% of cases, predominantly affecting the lung, diaphragm, abdominal lymph nodes and bones [1]. In the oral cavity, metastases are extremely rare [2] and are usually found at an advanced stage of cancer [3].…”

Section: Introductionmentioning

confidence: 99%

Rare Metastatic Lesion Affecting the Mouth: Case Report and Review

Curi¹,

Curra²,

Condezo³

et al. 2017

JCT

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The presence of metastases in the oral cavity is considered quietly rare in the literature. Considering metastasis of hepatocellular carcinoma, the occurrence occurs in approximately 1% of cases. The objective of this study was to report a case of metastasis of hepatocellular carcinoma in gingiva, in a patient with a previous diagnosis of cancer presenting a poor prognosis. Furthermore, a review of reported cases has already been performed and found only 20 reports. This case report emphasizes the importance of including metastases in soft tissue of the mouth, in the differential diagnosis of lesions with benign aspect.

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