Hepatocellular carcinoma in association with hepatic focal nodular hyperplasia

Langrehr, Jan M.; Pfitzmann, Robert; Hermann, M; Radke, Cornelia; Neuhaus, P.; Pech, Maciej; Denecke, Timm; Felix, R; Hänninen, Enrique Lopez

doi:10.1080/02841850600570474

Cited by 33 publications

(29 citation statements)

References 18 publications

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“…The prevalence of FNH is approximately 0.9%. FNH appears more frequently in females (80-95%) in the third or fourth decade of life with indefinite etiology [6][7][8].…”

Section: Pathogenesismentioning

confidence: 98%

Management and surgical treatment for focal nodular hyperplasia in children

Yang

et al. 2008

Pediatr Surg Int

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Focal nodular hyperplasia (FNH) is rare in pediatric liver tumor. To investigate the experience in the appropriate management of pediatric FNH, the records of consecutive children who were managed at our institute from 2000 to 2007were reviewed for FNH. There were four males and nine females whose ages ranged from 26 months to 18 years with a mean of 11.7 years. FNH in most children was detected by medical examination for abdominal pain (61.5%) or other symptoms. All the 13 pediatric patients underwent liver resection. There was no operative death or postoperative complications. The children were regularly followed up ranging from 2 to 85 months and they were healthy without recurrence. For pediatric FNH patients with clinical symptoms or indefinite diagnosis, it is suggested that active surgical treatment by hepatectomy should be performed.

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“…The prevalence of FNH is approximately 0.9%. FNH appears more frequently in females (80-95%) in the third or fourth decade of life with indefinite etiology [6][7][8].…”

Section: Pathogenesismentioning

confidence: 98%

Management and surgical treatment for focal nodular hyperplasia in children

Yang

et al. 2008

Pediatr Surg Int

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“…Although there is no evidence in the literature for malignant degeneration of FNH, there are reports of FNH occurring simultaneously with hepatocellular carcinoma [15,16]. The case presented here is an interesting combination of a secondary hepatoblastoma most likely occurring adjacent to a posttherapy FNH.…”

Section: Discussionmentioning

confidence: 64%

Hepatoblastoma presenting with focal nodular hyperplasia after treatment of neuroblastoma

Gutweiler

Kim

et al. 2008

Journal of Pediatric Surgery

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“…Focal nodular hyperplasia can occur close to a malignancy such as hepatoblastoma or hepatocellular carcinoma [11][12][13]. If there are other nodules adjacent to FNH, the possibility of malignancy should be considered.…”

Section: Discussionmentioning

confidence: 99%