Hepatolobectomy‐induced depression of hepatic circulation and metabolism in the dog is counteracted by isoflurane, but not by halothane

Abstract

The present data indicate that isoflurane has less adverse effect than halothane anesthesia on hepatic circulation, oxygen delivery and energy charge in hepatolobectomy cases.

Effects of Dopamine, Dobutamine, Amrinone and Milrinone on Regional Blood Flow in Isoflurane Anesthetized Dogs

“…Liver accepts blood supply through hepatic artery and portal vein. Proportion of hepatic blood flow through hepatic artery and through portal vein is approximately 1:2 to 1:3 under 1.5 MAC ISO anesthesia [21]. However arterial blood contains more volume of oxygen and hepatic artery supplies half of total oxygen transporting to liver [18].…”

Hepatic function during xenon anesthesia in pigs

“…No differences in any other measured liver parameters such as ALT, LDH and urea production rate were found. Volatile anesthetics, especially halothane and to a lesser extend isoflurane, are known to change hepatic perfusion distribution towards increased hepatic arterial perfusion (8). This effect was not found in our study (9).…”

Perioperative management of patients with concomitant liver diseases

“…В печени существует механизм ауторегуляции кровотока, направленный на поддержание ОПК, который заключается в увеличении КПА при снижении КПВ [29]. Данный адаптационный механизм позволяет сохранять постоянство ОПК в условиях гиповолемии, воздействия неблагоприятных эффектов абдоминальных операций или массивного кровотечения [30]. Галотан в значительной степени угнетает его, в то время как изофлюран и севофлюран способствуют его функционированию [31].…”