Hepatoma registry of the western world

Current Surgical Management of Liver Tumors

“…Median survival in unresected patients ranges from 1 to 9 months. 18,19 Fortunately, the surgical treatment of hepatic tumors and perioperative care have allowed major advances in recent years. Hepatic surgery offers demonstrable benefits of prolongation of life and, in many patients, cure of their disease.…”

“…10,26 Currently, at centers experienced in hepatic surgery, perioperative mortality (i.e., death within 30 days of surgery) in cirrhotic patients is approximately 15% and is less than 5% when performed in noncirrhotic patients. 4,13,16,18,26 Perioperative morbidity ranges from 13% to 50% but has shifted in character in recent years. 7 In the past, intra-abdominal sepsis and biliary leak were the most common complications and often required reoperation.…”

“…28,29 Using current techniques, overall 5-year survival rates after HCC resection range from 32 to 59%. [3][4][5][6]18,30 when broken down by AJCC staging, 5year survival is 41 to 69% for patients with stage I disease, 46 to 52% for patients with stage II disease, 29 to 32% for patients with stage III disease, and 5 to 19% for patients with stage IV disease. 10,12,31 Interestingly, in most series the type of resection performed did not significantly affect survival as long as the margin of resection was at least 1 cm.…”

“…10 The incidence of cirrhosis in Asia is approximately 70% compared with only 40% in Western countries. 10,18 In the United States the tumor is most often associated with underlying cirrhosis secondary to infectious hepatitis or the intake of alcohol. The mechanism of causation for development of the tumor due to alcoholism remains obscure, although it may be due to replicative errors that occur during hepatocyte regeneration after toxic insult.…”

Bedeutung bildgebender Verfahren für die chirurgische Indikationsstellung bei soliden Lebertumoren

“…Im Hepatomregister fü r die westliche Welt wurden folgende Daten als prognostisch relevant charakterisiert: Vorliegen einer Cirrhose, portaler/coeliacaler Lymphknotenbefall, Multizentrizitä t und Resektionsrand < 1 cm [38]. Im Hepatomregister fü r die westliche Welt wurden folgende Daten als prognostisch relevant charakterisiert: Vorliegen einer Cirrhose, portaler/coeliacaler Lymphknotenbefall, Multizentrizitä t und Resektionsrand < 1 cm [38].…”