Hepatoprotective activities of Lappula barbata and Plantago holosteum against paracetamol induced liver damage in rats and their in vitro antioxidant effects

Soliman, GA; Yusufoğlu, Hasan Soliman; Tatlı-Çankaya, I; Abdel-Rahman, RF; Anul, Serap Arabaci; Akaydın, Galip

doi:10.1055/s-0036-1596397

Cited by 4 publications

(6 citation statements)

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“…Also, earlier reports were for anti-inflammatory, analgesic, and antipyretic activities (Alamgeer et al 2016). No use report of Lappula barbata is from the communities of Shingar, but earlier reports elaborated its importance as antiviral and antiinflammatory activities (Soliman et al 2016). Also, no use report of Onosma limitaneum is from the interviews of communities during the survey of Shingar, but the plant has been identified to have great medicinal importance (Sarangzai et al 2013).…”

Section: Ethnobotanical Inventory In the Folk Community Of Shingharmentioning

confidence: 99%

Species diversity and ethnobotanical inventory of wild flora used by the folk community of Shinghar Balochistan, Pakistan

2021

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Abstract. Haq AU, Saeed S, Ahmed A. 2021. Species diversity and ethnobotanical inventory of wild flora used by the folk community of Shinghar Balochistan, Pakistan. Nusantara Bioscience 13: 148-157. Upper Suleiman Mountain of Shinghar Balochistan, Pakistan is little known, the structural and floristic composition are poorly understood. The dominant socio-linguistic groups of the area are Pashtoon tribes, having a long history of medicinal plants utilization as a part of their indigenous primary health care system. The present study was carried out to describe the plant species diversity of Shinghar, and to the inventory of some important wild medicinal, edible and endemic plants of the region. A total of 102 species belonging to 42 families and 88 genera were recorded. Herbs were dominant comprising 62% of documented plants, followed by shrubs (26%), and trees (14%). Medicinal plants of the area are being used in treatments of many ailments like joint pains, stomach problems, skin allergies and inflammation.. Edible plants were 14% of total recorded plants. The documented plants were also used for other use-categories than medicinal and edible purposes including fodder, fencing, and ornamental. In addition, some of the medicinal plants were considered poisonous but used for medicine. Elevation of the area ranged from 1700 to 3400 meters above sea level. The dominating tree was Pinus gerardiana, and the area is also known as the Chilghoza Forest. Asteraceae was the dominating family in the area with 14 species, followed by Lamiaceae (7 species), Poaceae (6 species), Solanaceae, Leguminosae, Fabaceae, and Apocynaceae with 5 species each. The results revealed the importance of endemic and endangered plants of area which are need to be conserve. Moreover, the present study highlighted species diversity not earlier described from high altitudes.

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Section: Ethnobotanical Inventory In the Folk Community Of Shingharmentioning

confidence: 99%

Species diversity and ethnobotanical inventory of wild flora used by the folk community of Shinghar Balochistan, Pakistan

2021

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“…Antiviral, anti-inflammatory, antifungal, hepatoprotective, analgesic, antibacterial, and cytotoxic effects have been previously reported on distinct Plantago species. [1,2] Earlier investigations on Plantago species showed that phenyl carboxylic acid derivatives, iridoid glycosides, flavonoids, and phenylethanoid glycosides are the main compounds. [3,4] In Turkey, especially the leaves of P. major, P. lanceolata and the seeds of P. psyllium are commonly employed to treat the abscess and wound to treat cancer, urinary infections, constipation, and diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…[6] Several phenolic acids, iridoid glucosides and flavonoids, have been previously isolated from P. subulata L. These secondary metabolites have been thought responsible for their hepatoprotective and antioxidant effects. [2,4] Carbonic anhydrase enzymes (CAs) catalyze hydration and dehydration reactions of H 2 CO 3 , and CO 2 ; in the dehydration reaction carbonic acid (H 2 CO 3 ) is converted to CO 2 . [7][8][9] CAs have a crucial role in the acid-base balance by maintaining a crucial buffering system for the body tissues and fluids.…”

Section: Introductionmentioning

confidence: 99%

Isolation of Some Phenolic Compounds from Plantago subulata L. and Determination of Their Antidiabetic, Anticholinesterase, Antiepileptic and Antioxidant Activity

Özaslan

Kaya

Demir

et al. 2022

Chemistry & Biodiversity

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In the current study, some phenolic compounds, including acteoside, isoacteoside, echinacoside, and arenarioside purified and characterized from Plantago subulata. These compounds were tested for its antioxidant potential, including Fe3+ and Cu2+ reductive ability and Fe2+ chelating effects. The inhibitory effects of isolated phenolic compounds were tested towards human carbonic anhydrase I and II isoenzymes (hCA I and hCA II), butyrylcholinesterase (BChE) acetylcholinesterase (AChE), aldose reductase (AR) and α‐glycosidase (α‐gly). Ki values were found these compounds in range of 0.24±0.05–1.38±0.34 μM against hCA I, 0.194±0.018–1.03±0.06 μM against hCA II, 0.043±0.01–0.154±0.02 μM against AChE, 3.92±1.08–11.93±4.45 μM against BChE, 0.082±0.0008–1.68±0.42 μM against AR, and 6.93±2.74–17.17±6.70 μM against α‐glycosidase. As a result, isolated compounds displayed inhibition effects against studied all metabolic enzymes. They are promising candidates for treating disorders like Alzheimer's disease, diabetes mellitus, glaucoma, leukemia, and epilepsy.

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“…The genus Plantago that involves about 260 species with a worldwide distribution is formed by 21 species in the flora of Turkey and widely used as folk medicine in Anatolia [1][2][3]. Various biological activities such as wound healing, anti-inflammatory, antibacterial, antiviral, antifungal, analgesic, cytotoxic, hepatoprotective, and antitumoral effects were reported for different Plantago species previously [4][5][6][7][8][9]. Iridoid glucosides, phenylethanoid glycosides, flavonoids, triterpenes, and phenolic acids were isolated from the aerial parts of Plantago species up to date [3,6,10,11].…”

Section: Introductionmentioning

confidence: 99%

“…A few studies on P. holosteum Scop., widely found in Central and West Anatolia, showed that iridoid glucosides, phenylethanoid glycosides, and phenolic acids are the main constituents of the plant that are responsible for its hepatoprotective, antioxidant, cytotoxic, anti-inflammatory, and wound healing effects [5,7,11].…”

Section: Introductionmentioning

confidence: 99%

Enzyme inhibitory assessment of the isolated constituents fromPlantago holosteumScop.

Dereli

Genç

Saraçoğlu

et al. 2020

Zeitschrift Für Naturforschung C

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Plants of the Plantago genus are widely used in Turkish folk medicine especially for the treatment of wound, abscess, and inflammation. The aqueous extract and five phenylethanoid glycosides acteoside (1), arenarioside (2), echinacoside (3), isoacteoside (4), and leucosceptoside A (5) isolated from the aerial parts and roots of Plantago holosteum Scop. (Plantaginaceae) were tested for their possible inhibitory activity against hyaluronidase, elastase, and collagenase, related to wound pathogenesis. Even though the aqueous extract prepared from the aerial parts (36.26%) and roots (47.01%) and the isolated compounds acteoside (29.13%), echinacoside (28.73%), and isoacteoside (31.69%) exerted a notable inhibition, arenarioside and leucosceptoside A were found inactive in the hyaluronidase enzyme inhibition test. Similar results were obtained from the collagenase enzyme inhibition test. The aqueous extract prepared from the aerial parts (31.09%) and roots (35.17%), echinacoside (25.13%), and isoacteoside (23.85%) exerted a notable inhibition in this test. However, none of the extracts and isolated compounds displayed elastase enzyme inhibitory activity. The experimental data demonstrated that P. holosteum displayed a remarkable enzyme inhibitory activity against hyaluronidase and collagenase. This paper is the first report regarding the in vitro enzyme inhibitory activity of P. holosteum.

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Hepatoprotective activities of Lappula barbata and Plantago holosteum against paracetamol induced liver damage in rats and their in vitro antioxidant effects

Cited by 4 publications

References 0 publications

Species diversity and ethnobotanical inventory of wild flora used by the folk community of Shinghar Balochistan, Pakistan

Species diversity and ethnobotanical inventory of wild flora used by the folk community of Shinghar Balochistan, Pakistan

Isolation of Some Phenolic Compounds from Plantago subulata L. and Determination of Their Antidiabetic, Anticholinesterase, Antiepileptic and Antioxidant Activity

Enzyme inhibitory assessment of the isolated constituents fromPlantago holosteumScop.

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