Hepatoprotective activity of Adhatoda vasica aqueous leaf extract on d-galactosamine-induced liver damage in rats

Bhattacharyya, Dipankar; Pandit, Sudipta; Jana, Utpal; Sen, S. K.; Sur, Tapas Kumar

doi:10.1016/j.fitote.2004.10.014

Cited by 47 publications

(24 citation statements)

References 12 publications

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“…Due to the radical scavenging potential of these phytochemicals, toxicity level reduces and body tends back towards normalcy (Laszczyk et al, 2006). Several studies have shown the hepatoprotective effects of Justicia leaves (Pandit et al, 2004;Bhattacharya et al, 2005;Krishna et al, 2010), but no work has reported on flowers of J. adhatoda. It has been reported that due to its antioxidant potential, J. adhatoda ethanolic extracts pretreatment significantly prevents radiation induced chromosomal eccentricity in bone marrow cells and reduces stickiness of chromosomes .…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effects of Justicia adhatoda L. against carbon tetrachloride (CCl4) induced liver injury in Swiss albino mice

Afzal¹

2013

Afr. J. Pharm. Pharmacol.

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Medicinal plants are believed to be a precious natural reservoir and have been continuously studied for their pharmacological activities against various ailments, liver being no exception. Leaves of Justicia adhatoda L. are being extensively used against many human ailments. Hepatoprotective effects of J. adhatoda L. leaves and flowers were investigated on carbon tetrachloride (CCl 4 ) induced liver damage in Swiss albino mice. Liver injury was assessed by estimation of biochemical parameters which includes liver function tests and supplemented by histopathological examination of liver. Aqueous, ethanolic and methanolic extracts of different concentrations were given orally and activities of these extracts were compared with standard drug (silymarin). The results showed that J. adhatoda leaves and flowers showed unambiguous hepatoprotective activity against CCl 4 induced liver toxicity. It was also concluded that different concentrations of leaves and flowers of J. adhatoda did not show any sign and symptoms of toxicity and mortality.

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Section: Discussionmentioning

confidence: 99%

Hepatoprotective effects of Justicia adhatoda L. against carbon tetrachloride (CCl4) induced liver injury in Swiss albino mice

Afzal¹

2013

Afr. J. Pharm. Pharmacol.

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“…[67] In another experiment, AV leaf showed significant hepatoprotective effect at doses of 50-100 mg/kg on liver damage induced by D-galactosamine in rats. [68] Radioprotection Activity…”

Section: Effect On Gastrointestinal Tractmentioning

confidence: 99%

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Kapgate¹

2017

IJGP

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Natural products are the most important source for discovery of new and effective drug molecules. The emergence of drug-resistant pathogens and the increase in diseases affecting the immune system have greatly intensified the need to investigate new bioactive metabolites for potential pharmaceutical and industrial applications. Ayurvedic classics have a unique wealth of medicinal plants and vast traditional knowledge of herbal medicine for the cure of various diseases. Adhatoda vasica (Nees) (AV) of family Acanthaceae, is a shrub growing throughout the Indian peninsula. The frequent use of AV has resulted in its inclusion in the WHO manual -The Use of Traditional Medicine in Primary Health Care. Thus, extensive research work has been conducted on the AV. The present article is an endeavor to review the ethanopharmacological evidence of therapeutic uses of AV in nutshell.

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“…The aqueous leaf extracts of Adhatoda vasica has shown hepatoprotective activity in d ‐galactosamine‐induced liver damage in rats. Further studies on this plant revealed the presence of two pharmacologically important quinazoline alkaloids, vasicine, and vasicinone [48]. The ether extract of Luffa echinata , which contains α‐eleterin, 2–epicucurbitacin B, and cucurbitacin B, showed significant protection against CCl 4 ‐induced liver damage in rats.…”

Section: Chemistrymentioning

confidence: 99%

Indian herbal medicines in the treatment of liver diseases: problems and promises

Girish

Pradhan

2011

Fundamemntal Clinical Pharma

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Plant drugs are known to play a major role in the management of liver diseases. There are many plants and their extracts that have been shown to possess hepatoprotective activities. There are more than 300 preparations in Indian system of medicine for the treatment of jaundice and chronic liver diseases. About 600 commercial herbal formulations with claimed hepatoprotective activity are being sold all over the globe. The active phytochemical fraction that imparts hepatoprotective activity has been identified in many plants. These phytochemicals can be isolated and developed as single-ingredient drugs, with quality and standards of modern medicine. The major problem faced with herbal products is their standardization and their quality assurance. There can be batch-to-batch variations in their efficacies as a result of natural and genetic alterations, seasonal changes, differences in soil and climatic conditions, and nutritional status of the medicinal plant. Pharmacological validation of each hepatoprotective plant should include efficacy evaluation against liver diseases induced by various agents. The most effective drugs for each kind of liver disease have to be selected by separate efficacy evaluations. To treat liver disease of known, unknown, or multiple causes, a combination of different herbs with active fractions (or purified compounds) has to be developed. They may prove to be useful in the treatment of infective, toxic, and degenerative diseases of the liver.

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Hepatoprotective activity of Adhatoda vasica aqueous leaf extract on d-galactosamine-induced liver damage in rats

Cited by 47 publications

References 12 publications

Hepatoprotective effects of Justicia adhatoda L. against carbon tetrachloride (CCl4) induced liver injury in Swiss albino mice

Hepatoprotective effects of Justicia adhatoda L. against carbon tetrachloride (CCl4) induced liver injury in Swiss albino mice

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Indian herbal medicines in the treatment of liver diseases: problems and promises

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