Hepatoprotective activity of alcoholic and aqueous extracts of leaves of Tylophora indica (Linn.) in rats

Abstract

Objective: To investigate the hepatoprotective activity of alcoholic (ALLT) and aqueous (AQLT) extracts of leaves of Tylophora indica (asclepiadaceae) against ethanol-induced hepatotoxicity. Materials and Methods: Leaf powder of Tylophora indica was successively extracted with alcohol and water. Preliminary phytochemical tests were done and the LD Departments of Pharmacology for both extracts determined. The hepatoprotective activity of the ALLT and AQLT were and *Pharmaceutical Chemistry, assessed in ethanol-induced hepatotoxic rats. V. L. College of Pharmacy, Results: The ALLT showed presence of alkaloids, carbohydrates, steroids, saponins and Raichur, India triterpenes, while alkaloids, carbohydrates and saponins were present with AQLT. The ALLT did not produce any mortality even at 5000 mg/kg while LD

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