Hepatoprotective Activity of Aqueous Extract of Oxalis Debilis Kunth Against Ccl4 - Induced Liver Damage

Athokpam, Rojini; Bawari, Meenakshi; Choudhury, Manabendra Dutta

doi:10.22159/ajpcr.2017.v10i9.19100

Cited by 4 publications

(5 citation statements)

References 14 publications

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“…Various herbal preparations impart their hepatoprotective effects by reducing the levels of these enzymes [11,26,31,32] and improving cellular morphology [26][27][28]. Our results are in agreement with these reports.…”

Section: Discussionsupporting

confidence: 91%

Antioxidant and Hepatoprotective Effect of Swertia Chirata on Hypoxia-Induced Oxidative Stress in Wistar Rats

Kaushal

Singh

Thakur

2019

Asian J Pharm Clin Res

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Objective: Swertia chirata has been used in traditional and folklore medicine to treat several ailments such as hepatic disorders. However, the mechanistic and experimental justification to its traditional use is lacking. The present study was aimed to investigate the hepatoprotective potential of S. chirata during hypoxia (HYP)-induced hepatic damage in Wistar rats and to determine the underlying mechanism.Methods: Hydroalcoholic extract of S. chirata was prepared using Soxhlet extraction. Animals were divided into six groups (n=5). Animals in the HYP groups were subjected to HYP for 3 days (10% O2) to induce oxidative stress and hepatic damage. 50 and 100 mg/kg extract treatments were provided orally once daily for 7 days after which animals were sacrificed, and biochemical investigations for oxidative stress, liver function tests, and hepatic histopathology were performed.Results: HYP-induced marked oxidative stress as indicated by the significantly elevated mitochondrial ROS generation, lipid peroxidation, glutathione, and depleted catalase levels. Liver function test indicated hepatic damage as the levels of serum glutamic-oxaloacetic transaminase, serum glutamic pyruvic transaminase, and aspartate transaminase were significantly elevated in HYP animals. S. chirata treatment alleviated oxidative stress and improved liver functions in a dose-dependent manner. Liver histopathology confirmed the marked hepatic damage induced by HYP and revealed that S. chirata efficiently rescued liver from hypoxic damage.Conclusion: Hydroalcoholic extract of S. chirata is a potent hepatoprotective intervention which was associated with its potential to alleviate oxidative stress and improve liver functions. Moreover, it could find clinical application as a safer and alternative remedy for liver ailments.

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Section: Discussionsupporting

confidence: 91%

Antioxidant and Hepatoprotective Effect of Swertia Chirata on Hypoxia-Induced Oxidative Stress in Wistar Rats

Kaushal

Singh

Thakur

2019

Asian J Pharm Clin Res

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“…There were many phagocytic organizations around the vessels and between the liver cells. This result was consistent with studies of Kang and Koppula (2014), Athokpam et al (2017), Singhal and Gupta (2012). 15,21,22 CCl4 compromised-mice treated with Silymarin had a recovery of liver cells (Figure 3.III).…”

Section: Liver Protective Effectsupporting

confidence: 93%

“…The phagocytic organizations were significantly reduced compared to the group of mice administered with CCl4, concentrating mainly around vascular structures, demonstrating the liver protective effects of Silymarin. 21,23,24 The hepatocytes of mice with liver damage by CCl4 treated with EM extract at concentrations of 200, 400 and 800 mg/kg were all well improved (Figure 3. IV, V, VI).…”

Section: Liver Protective Effectmentioning

confidence: 97%

Acute Toxicity and Liver Protective Effects of Elephantopus mollis H.B.K

2021

TJNPR

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Elephantopus mollis (EM) is a wild species and is commonly used in folk medicine as remedy for various ailments. Some uses of this plant has been documented in the scientific literature. However, studies on the medicinal properties of this specie remain rarely published and the specie has not been recorded in the Vietnamese pharmacopeia. The present study therefore assessed the acute toxicity and liver-protective effects of Elephantopus mollis (EM). The acute toxicity of the aqueous extract of EM in mice was assessed following the method stipulated by the Organization for Economic Cooperation and Development (OECD), while the hepatoprotective effect was assessed following previously reported method. Whole plant extract of EM was not toxic to the tested mice (at a dose of 9,000 mg/kg) and showed good liver protection. The plant extract had the ability to reduce the degradation of liver cells by reducing the amount of liver enzymes. At a dose of 400 mg/kg EM, the reduction efficiency of AST and ALT in tested mice were 71.43 ± 11.36% and 63.82 ± 19.43%, respectively, when compared with the negative control group after 2 weeks of treatment. Mice liver morphology and histopathology treated with EM extract showed a decent improvement. The liver cells size of mice treated with EM extract decreased significantly (28.02 ± 6.33 µm) compared to the mice in the negative control group (34.82 ± 6.36 µm). The results suggest the potential effect of this extract as a hepatoprotective agent towards liver damage without any oral acute toxicity effect.

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“…It has been show that pre and post-treatment with the aqueous extract of the leaves led to a significant reduction in the serum level of enzymes (serum transaminase, phosphatase and bilirubin) and total protein content compared with the ccl 4 -treated groups (48). Thus, the leaf extracts can be utilized in the pharmaceutical and food industry due to their richness in phenolics and flavonoids.…”

Section: Anti-inflammatory and Antiproliferative Activitiesmentioning

confidence: 99%

“…Hepatoprotective activity. The aqueous extract of P. pashia leaves have been shown to exhibit hepatoprotective activity against carbon tetrachloride (ccl 4 )-induced liver damage (48).…”

Section: Anti-inflammatory and Antiproliferative Activitiesmentioning

confidence: 99%

Traditional uses, nutrition, phytochemistry and various pharmacological properties of Indian wild pear (Review)

2021

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The consumption of wild edible fruits for nutritional and medicinal benefits has been known for a long time. These naturally occurring fruit plants can thrive well under adverse climatic conditions and are being harvested and marketed locally. Pyrus pashia (P. pashia; Buch.-Ham. ex D. Don; family, Rosaceae), commonly known as 'wild edible or Himalayan pear' is one of such underutilized trees. It is widely distributed in temperate regions up to an altitude of 2,000 m in Western Himalaya. It has broad applications in traditional therapeutics for the treatment of diseases, such as eye infections, sore throat, diarrhea, stomach disorders and other infectious diseases. Chlorogenic acid, flavan-3-ols, gallic acid, tannins, alkaloids, hydroquinone, terpenoids and its isomers have been isolated and identified from the leaf, fruit, flower and bark portion of P. pashia. The phytochemicals present in the P. pashia tree may be responsible for the traditional beneficial health effects of the plant. Numerous scientific studies on P. pashia have validated the general uses of the plant by the native population; however, the data on its pharmacological properties and the mechanisms involved are insufficient. The present review aimed to provide a critical evaluation of the distribution, traditional uses, phytochemicals present, pharmacological activities and nutritional value of different plant parts of P. pashia. Detailed research is required on individual phytochemicals present and toxicological studies at the gene level. In-depth molecular studies may also confirm the various pharmaceutical claims for the development of novel pharmaceutical drugs and functional food products. Contents1. Introduction 2. Habitat and morphology 3. Traditional uses of various parts of P. pashia 4. Nutritive value 5. Phytochemistry and pharmacological properties 6. conclusion and future perspectives

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Hepatoprotective Activity of Aqueous Extract of Oxalis Debilis Kunth Against Ccl4 - Induced Liver Damage

Cited by 4 publications

References 14 publications

Antioxidant and Hepatoprotective Effect of Swertia Chirata on Hypoxia-Induced Oxidative Stress in Wistar Rats

Antioxidant and Hepatoprotective Effect of Swertia Chirata on Hypoxia-Induced Oxidative Stress in Wistar Rats

Acute Toxicity and Liver Protective Effects of Elephantopus mollis H.B.K

Traditional uses, nutrition, phytochemistry and various pharmacological properties of Indian wild pear (Review)

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