Hepatoprotective Activity of Dried‐ and Fermented‐Processed Virgin Coconut Oil

Zakaria, Zainul Amiruddin; Rofiee, Mohd Salleh; Somchit, M. N.; Zuraini, A.; Sulaiman, Mohd Roslan; Teh, Lay Kek; Salleh, Mohd Zaki; Long, Kamariah

doi:10.1155/2011/142739

Cited by 78 publications

(58 citation statements)

References 56 publications

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“…However, a reduction in the liver weight of the AmSO0.5 and AmSO1.0 groups compared to CtrlAmSO group was observed ( Table 2). The hepatoprotective effect has been identified in coconut oil, the study of Zakaria et al, (2011). Treatment with virgin coconut oil reduced the hepatotoxicity induced by acetaminophen, reduced the dosages of liver enzymes and improved liver morphology.…”

Section: Discussionmentioning

confidence: 99%

Potential of <em>Annona muricata</em> L. seed oil: phytochemical and nutritional characterization associated with non-toxicity

Pinto

Souza

et al. 2018

Grasas y Aceites

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SUMMARY:The aim of this study was to evaluate the nutritional quality, phenolic compounds, fatty acid and antioxidant activity in vitro as well as a toxicological screening of A. muricata seed oil in vivo. The chemical composition and quantification of phenolic compounds were determined by the Adolfo Lutz Institute normative. The antioxidant activity was evaluated by DPPH, FRAP and ABTS methods. The oil was extracted by chloroform/ methanol and precipitated crude (AmPtO) and supernatant oils (AmSO) were obtained. The fatty acid profile was evaluated by gas chromatography and total compounds by HPLC-DAD. BALB/C mice received AmPtO and AmSO (0.5 and 1.0mL·Kg -1 ) for 14 days. Toxicity parameters were assessed. The major fatty acids in the oil were oleic (39.2%) and linoleic (33%). HPLC-DAD suggested the presence of acetogenins (annonacin: 595 [M-H] -), with a greater presence in AmPtO. The AmPtO group showed toxicity, which may be related to the acetogenin content in AmPtO. The AmSO group showed no toxicity and this oil has potential for food or medicinal use. KEYWORDS:Acetogenins; Annona muricata seeds; Annonacin; Linoleic acid; Oleic acid RESUMEN: Potencial del aceite de Annona muricata L.: Caracterización nutricional y fitoquímica asociada con no toxicidad. El objetivo de este estudio fue evaluar la calidad nutricional, compuestos fenólicos, ácidos grasos, actividad antioxidante in vitro y evaluación toxicológica del aceite de las semillas de la Annona muricata. La composición química y los compuestos fenólicos se determinaron de acuerdo con las normas del Instituto Adolfo Lutz y la actividad antioxidante por métodos de DPPH, FRAP y ABTS. El aceite fue extraído con cloroformo/metanol obteniéndose un precipitado crudo (AmPtO) y un aceite sobrenadante (AmSO). El perfil de ácidos grasos fue evaluado por cromatografía gaseosa y los compuestos fitoquímicos mediante HPLC-DAD. BALB/C recibieron AmPtO y AmSO (0,5 y 1,0 mL·kg

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Section: Discussionmentioning

confidence: 99%

Potential of <em>Annona muricata</em> L. seed oil: phytochemical and nutritional characterization associated with non-toxicity

Pinto

Souza

et al. 2018

Grasas y Aceites

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“…On the other hand, in some experiments it has been shown that virgin coconut oil has hepato-protective activity on rabbits (Zakaria et al, 2011). Moreover, it was shown that the replacement of soyabean oil by coconut oil in the feed of broilers lowered the level of low density lipoprotein (LDL)-cholesterol and favourably affected lipid profile in serum (Wang et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Addition of coconut oil to the diet based on maize dried distilled grains with solubles (DDGS) alters miR-122a expression in the pig liver

Oczkowicz¹,

Pawlina²,

Bugno‐Poniewierska³

et al. 2017

J. Anim. Feed Sci.

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“…A slightly modified method of Zakaria et al, (2011) for CCl 4 toxicity assay was used. The rats were randomly divided into six groups each consisting of six rats (n = 6).…”

Section: -Induced Toxicitymentioning

confidence: 99%

In Vivo Carbon Tetrachloride-Induced Hepatoprotective and in Vitro Cytotoxic Activities of Garcinia Hombroniana (Seashore Mangosteen)

Jamila

Khan

Atlas

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Garcinia hombroniana, known as "manggis hutan" (jungle mangosteen) in Malaysia, is distributed in tropical Asia, Borneo, Thailand, Andaman, Nicobar Islands, Vietnam and India. In Malaysia, its ripened crimson sour fruit rind is used as a seasoning agent in curries and culinary dishes. Its roots and leaves decoction is used against skin infections and after child birth. This study aimed to evaluate in vivo hepatoprotective and in vitro cytotoxic activities of 20% methanolic ethyl acetate (MEA) G. hombroniana bark extract. Materials and Methods: In hepatoprotective activity, liver damage was induced by treating rats with 1.0 mL carbon tetrachloride (CCl 4 )/kg and MEA extract was administered at a dose of 50, 250 and 500 mg/kg 24 h before intoxication with CCl 4 . Cytotoxicity study was performed on MCF-7 (human breast cancer), DBTRG (human glioblastoma), PC-3 (human prostate cancer) and U2OS (human osteosarcoma) cell lines.1 H, 13 C-NMR (nuclear magnetic resonance), and IR (infrared) spectral analyses were also conducted for MEA extract. Results: In hepatoprotective activity evaluation, MEA extract at a higher dose level of 500 mg/kg showed significant (p<0.05) potency. In cytotoxicity study, MEA extract was more toxic towards MCF-7 and DBTRG cell lines causing 78.7% and 64.3% cell death, respectively. MEA extract in 1 H,

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Hepatoprotective Activity of Dried‐ and Fermented‐Processed Virgin Coconut Oil

Cited by 78 publications

References 56 publications

Potential of <em>Annona muricata</em> L. seed oil: phytochemical and nutritional characterization associated with non-toxicity

Potential of <em>Annona muricata</em> L. seed oil: phytochemical and nutritional characterization associated with non-toxicity

Addition of coconut oil to the diet based on maize dried distilled grains with solubles (DDGS) alters miR-122a expression in the pig liver

In Vivo Carbon Tetrachloride-Induced Hepatoprotective and in Vitro Cytotoxic Activities of Garcinia Hombroniana (Seashore Mangosteen)

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