Hepatoprotective Activity of Gentisic Acid on 5-Fluorouracil-induced Hepatotoxicity in Wistar Rats

Pujari, Rohini; Bandawane, D. D.

doi:10.4274/tjps.galenos.2020.95870

Cited by 20 publications

(10 citation statements)

References 22 publications

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“…In the present study increased the activities of ALT, AST attributed due to liver dysfunction. A similar increase in ALT, AST was observed in rats by [11][12][13] . Resveratrol offers hepatoprotection by influencing the levels of lipid peroxidation products and liver markers, which could be due to their free radical scavenging and antioxidant property [14] .…”

Section: Discussionsupporting

confidence: 85%

Evaluation and comparison of protective actions resveratrol and vitamin-e in 5-flourouracil induced hepatotoxicity

Harish¹,

Shivakumar²,

Kumar³

et al. 2021

Pharma Innovation

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Section: Discussionsupporting

confidence: 85%

Evaluation and comparison of protective actions resveratrol and vitamin-e in 5-flourouracil induced hepatotoxicity

Harish¹,

Shivakumar²,

Kumar³

et al. 2021

Pharma Innovation

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“…Phytomolecules like Vitexin and vitexin analogs ( Duan et al, 2020 ), Kaempferol and kaempferol analogs ( Wang M. et al, 2015 ; Wang et al, 2015c ), Quercetin-3-methyl ether ( Tseng et al, 2012 ), Quercetin and quercetin analogs ( Miltonprabu et al, 2017 ), Acacetin analogs ( Cho H.-I. et al, 2014 ), Stigmasterol ( Carter et al, 2007 ), β-Sitosterol ( Abdou et al, 2019 ), Ellagic acid ( Girish and Pradhan, 2012 ), Ferulic acid ( Rukkumani et al, 2004 ), p-Coumaric acid ( Parvizi et al, 2020 ), 2,5-Dihydroxybenzoic acid ( Pujari and Bandawane, 2021 ), Chlorogenic acid ( Chen et al, 2019 ), and β-Carotene ( Manda and Bhatia, 2003 ) which were previously reported from Alternanthera sessilis (L.) R.Br. ex DC., may be the contributory constituents towards the elicited hepatoprotective activity.…”

Section: Introductionmentioning

confidence: 99%

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

et al. 2022

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Ethnopharmacological relevance: The genus Alternanthera (Amaranthaceae) comprises 139 species including 14 species used traditionally for the treatment of various ailments such as hypertension, pain, inflammation, diabetes, cancer, microbial and mental disorders.Aim of the review: To search research gaps through critical assessment of pharmacological activities not performed to validate traditional claims of various species of Alternanthera. This review will aid natural product researchers in identifying Alternanthera species with therapeutic potential for future investigation.Materials and methods: Scattered raw data on ethnopharmacological, morphological, phytochemical, pharmacological, toxicological, and clinical studies of various species of the genus Alternanthera have been compiled utilizing search engines like SciFinder, Google Scholar, PubMed, Science Direct, and Open J-Gate for 100 years up to April 2021.Results: Few species of Alternanthera genus have been exhaustively investigated phytochemically, and about 129 chemical constituents related to different classes such as flavonoids, steroids, saponins, alkaloids, triterpenoids, glycosides, and phenolic compounds have been isolated from 9 species. Anticancer, antioxidant, antibacterial, CNS depressive, antidiabetic, analgesic, anti-inflammatory, and immunomodulator effects have been explored in the twelve species of the genus. A toxicity study has been conducted on 3 species and a clinical study on 2 species.Conclusions: The available literature on pharmacological studies of Alternanthera species reveals that few species have been selected based on ethnobotanical surveys for scientific validation of their traditional claims. But most of these studies have been conducted on uncharacterized and non-standardized crude extracts. A roadmap of research needs to be developed for the isolation of new bioactive compounds from Alternanthera species, which can emerge out as clinically potential medicines.

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“…In our research, the level of liver enzymes measured after treatment with 5-FU substantially increased, compatible with other studies that demonstrated a considerable increment in liver damage and the level of liver biomarkers, including ALP, AST and ALT. 8,12,59,60 Also, our histological studies showed hyperemia, severe infiltration of inflammatory cells and severe vacuolar degeneration following treatment with 5-FU. This aligns with previous studies that observed hydropic degeneration and necrosis of liver cells after treatment with 5-FU.…”

Section: Discussionmentioning

confidence: 57%

Therapeutic benefit of melatonin in 5‐fluorouracil‐induced renal and hepatic injury

Mansoori,

Kazemi,

Almasi

et al. 2024

Basic Clin Pharma Tox

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Nephrotoxicity and hepatotoxicity include increased oxidative stress and apoptosis; as a result, liver and kidney damage are related to its pathogenesis. These are significant side effects caused in cancer patients treated with 5‐FU. In the research, 25 rats were divided into five groups, including control, 5‐FU, and 5‐FU + 2.5, 5, and 10 mg/Kg melatonin (MEL), and the protective impact of MEL against 5‐FU‐induced hepatorenal damage in rats was investigated. 5‐FU caused significant harm, resulting in severe renal failure and histopathological changes. It also increased BUN, creatinine, and hepatic function markers levels while decreasing superoxide dismutase and glutathione peroxidase activity. Additionally, 5‐FU led to a notable increase in malondialdehyde content. However, MEL co‐administration to rats reversed most biochemical and histologic effects. In the control and MEL+5‐FU groups, the values were comparable. The doses of MEL treatment had a significant positive impact on 5‐FU‐induced oxidative stress, apoptosis, lipid peroxidation, and kidney damage. Our data concluded that MEL has an ameliorative effect on hepatorenal damage caused by 5‐FU.

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Hepatoprotective Activity of Gentisic Acid on 5-Fluorouracil-induced Hepatotoxicity in Wistar Rats

Cited by 20 publications

References 22 publications

Evaluation and comparison of protective actions resveratrol and vitamin-e in 5-flourouracil induced hepatotoxicity

Evaluation and comparison of protective actions resveratrol and vitamin-e in 5-flourouracil induced hepatotoxicity

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

Therapeutic benefit of melatonin in 5‐fluorouracil‐induced renal and hepatic injury

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