Hepatoprotective activity of <i>Feronia limonia</i> root

Jain, Mahendra; Kapadia, Rakhee; Jadeja, Ravirajsinh N.; Thounaojam, Menaka C.; Devkar, Ranjitsinh; Mishra, S.H.

doi:10.1111/j.2042-7158.2012.01481.x

Cited by 13 publications

(8 citation statements)

References 23 publications

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“…The color intensity indirectly reflects the health of cells and functional mitochondria . Because of the simplicity and effectiveness of this protocol MTT assay is widely used for assessing cytotoxicity of various therapeutic agents, metal complexes, and nanoparticles . In our study interaction of ion gel with adherent A549 cells did not account for any mortality till the highest dose (200 μg mL −1 ) (Figure ).…”

Section: Resultsmentioning

confidence: 61%

Preparation of a Noncytotoxic Hemocompatible Ion Gel by Self-Polymerization of HEMA in a Green Deep Eutectic Solvent

Mukesh

Upadhyay

Devkar

et al. 2016

Macromol. Chem. Phys.

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Self‐polymerization of optimized amount of 2‐hydroxyethylmethacrylate (HEMA) in a natural deep eutectic solvent (NADES) is obtained by the complexation between choline chloride and fructose (ChCl:Fruc. 2:1) in the presence of indomethacin, an anti‐inflammatory drug resulted formation of a drug‐immobilized ion gel. The ion gel thus obtained is found to be stable in gastrointestinal fluid pH (GIF) and sustained release in simulated lower intestinal fluid for 20 h (88% release) at pH 6.8 and 96% release at pH 7.4 for 15 h (colon & blood pH) at physiological human body temperature (37 °C) of the drug is recorded. The drug can be stored in the gel matrices at room temperature for long durations such as 6 months without any degradation. The ion gel of poly‐HEMA obtained in the NADES does not appear to inhibit the growth of mammalian cells in vitro and is found to be compatible to human blood thus implying toward their potential for therapeutic applications as pH‐sensitive hydrophobic drug carrier for oral application as well as in tissue engineering.

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Section: Resultsmentioning

confidence: 61%

Preparation of a Noncytotoxic Hemocompatible Ion Gel by Self-Polymerization of HEMA in a Green Deep Eutectic Solvent

Mukesh

Upadhyay

Devkar

et al. 2016

Macromol. Chem. Phys.

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“…e liver is one of the most important vital organs in our body; it takes care of several essential physiological functions such as metabolism, secretion, and storage [1]. Moreover, the liver plays a crucial role in the detoxification and excretion of endogenous and exogenous substances such as xenobiotics, pharmaceutical drugs, and viral infections [1,2]. us, this indicated the vulnerability of the liver which is mostly threatened by the toxic effects of xenobiotic compounds, leading to hepatic insufficiency.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect ofZizyphus lotusL. (Desf.) Fruit against CCl₄-Induced Acute Liver Injury in Rat

Bencheikh

Kharchoufa

Choukri

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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In Morocco, “Zizyphus lotus L.” is one of the most widely and traditionally used plant species to treat various diseases, including liver disorders. The present study was conducted to evaluate the aqueous extract of Zizyphus lotus L. fruit against carbon tetrachloride- (CCL4-) induced liver damage in Wistar rats. The animals were daily treated with the aqueous extract of Zizyphus lotus L. fruit using two doses separately 200 and 400 mg/kg body weight for 14 days. CCL4 was injected intraperitoneally (1 ml/kg body weight) at two times, 7th and 14th days. At the end of the treatment, rats were sacrificed, and the blood was collected for the assessment of biochemical parameters. Moreover, the body weight as well as liver weight was determined. The injection of CCl4 to the rats induced various alterations such as the increase of relative liver weight, serum alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, total bilirubin, direct bilirubin, triglycerides, very low-density lipoproteins, total cholesterol (slight increase), creatinine, urea, uric acid, and malondialdehyde. On the contrary, the effects of CCL4 lead to the reduction in serum levels of high-density lipoprotein. However, the daily administration of the aqueous extract of Zizyphus lotus L. fruit to the injected rats with CCL4 restored this abnormal variation in these biochemical parameters to normal values. Based on the results obtained in this study, it seems that the aqueous extract of Zizyphus lotus L. fruit has an hepatoprotective effect against hepatic lesions induced by CCL4 in rats.

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“…The liver is a vital organ that functions as a centre for metabolism of nutrients (carbohydrates, proteins and lipids) and excretion of xenobiotics from the body, thereby providing protection against foreign substances through detoxification and elimination processes [1,2]. Due to increasing incidences of xenobiotic/chemically induced hepatotoxicity, there is a need for safe protective agents, in lieu of synthetic chemical compounds [3].…”

Section: Introductionmentioning

confidence: 99%

“…Scientifically, marine halophytes have been shown to have antibacterial [8], antifungal, antiplasmodial and anti-viral properties [9,10]. For instance, the hepatoprotective nature of terrestrial plants (Murraya koenigii [1], Feronia limonia [2,3,5], Tecomella undulata [11], Clerodendron glandulosum [6,12], etc.) has been studied extensively.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective activity ofCeriops decandra(Griff.) Ding Hou mangrove plant against CCl₄induced liver damage

Gnanadesigan

Sundaram

Anand

2017

Journal of Taibah University for Science

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In folklore medicine, Ceriops decandra is used to treat hepatitis. However, a scientific evaluation has not been performed. Thus, the present study was carried out to identify the hepatoprotective activity of plant parts (leaf, bark, collar, flower and hypocotyls) of C. decandra. In vitro antioxidant studies were carried out with DPPH, HRSA, NO, FRAP and LPO assays. The LD 50 was calculated and in vivo hepatoprotective activity was carried out with the leaf extract, which was found to be the most potent. The in vivo hepatoprotective activity was performed as follows: Group 1, control animals; Group 2, carbon tetrachloride (CCl 4)-treated animals; Group 3, silymarin (100 mg kg −1 bw p.o.) treated animals; Groups 4, 5 and 6, C. decandra treatment groups (100, 200 and 400 mg kg −1 bw). Histopathological scores were calculated with standard protocols. Of the selected different plant parts, the leaf extract showed maximum antioxidant scavenging properties. A study of the oral acute toxicity found C. decandra extract to be non-toxic up to 2000 mg kg −1 bw. The in vivo hepatoprotective nature of the leaf extract was identified as dose dependent and the levels of SGOT, SGPT, ALP, bilirubin, CHL and LDH were found to be significantly decreased (p < 0.05) compared with hepatotoxin groups. Histopathological scores did not show any significant variations between control and high dose (400 mg kg −1 bw) of leaf extract-treated animals. Preliminary phytochemical analysis of the leaf extract revealed the presence of phenolic groups, alkaloids, triterpenoids, flavonoids, catechin and anthraquinone. In conclusion, the hepatoprotective nature of the C. decandra leaf extract might be due to the occurrence of unique secondary metabolites and their antioxidant scavenging properties.

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Hepatoprotective activity of Feronia limonia root

Abstract: This has been the first scientific report on the hepatoprotective potential of F. limonia root bark methanolic extract and marmesin.

Cited by 13 publications

References 23 publications

Preparation of a Noncytotoxic Hemocompatible Ion Gel by Self-Polymerization of HEMA in a Green Deep Eutectic Solvent

Preparation of a Noncytotoxic Hemocompatible Ion Gel by Self-Polymerization of HEMA in a Green Deep Eutectic Solvent

Protective Effect ofZizyphus lotusL. (Desf.) Fruit against CCl₄-Induced Acute Liver Injury in Rat

Hepatoprotective activity ofCeriops decandra(Griff.) Ding Hou mangrove plant against CCl₄induced liver damage

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Hepatoprotective activity of Feronia limonia root

Abstract: This has been the first scientific report on the hepatoprotective potential of F. limonia root bark methanolic extract and marmesin.

Cited by 13 publications

References 23 publications

Preparation of a Noncytotoxic Hemocompatible Ion Gel by Self-Polymerization of HEMA in a Green Deep Eutectic Solvent

Preparation of a Noncytotoxic Hemocompatible Ion Gel by Self-Polymerization of HEMA in a Green Deep Eutectic Solvent

Protective Effect ofZizyphus lotusL. (Desf.) Fruit against CCl4-Induced Acute Liver Injury in Rat

Hepatoprotective activity ofCeriops decandra(Griff.) Ding Hou mangrove plant against CCl4induced liver damage

Contact Info

Product

Resources

About

Protective Effect ofZizyphus lotusL. (Desf.) Fruit against CCl₄-Induced Acute Liver Injury in Rat

Hepatoprotective activity ofCeriops decandra(Griff.) Ding Hou mangrove plant against CCl₄induced liver damage