Hepatoprotective activity of &lt;i&gt; Ficus carica&lt;/i&gt; leaf extract on rifampicin-induced hepatic damage in rats

Gond, N. Y.; Khadabadi, S. S.

doi:10.4103/0250-474x.43003

Cited by 78 publications

(40 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our result revealed that INH/RIF administration to rats increased the levels of serum AST and ALT compared to the normal rats this was agreed by [38,39]. The reduction in the levels of these parameters toward the respective normal values by Moringa oleifera is an indication of the stabilization of plasma membranes as well as repair of hepatic tissue damage caused by INH/RIF [40].…”

Section: Discussionsupporting

confidence: 84%

Protective Effects of Moringa oleifera extract on Isoniazid and Rifampicin Induced Hepatotoxicity in Rats: Involvment of Adiponectin and Tumor Necrosis Factor-α

elhameed¹,

Salama

Attia

et al. 2018

NIDOC-ASRT

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 84%

Protective Effects of Moringa oleifera extract on Isoniazid and Rifampicin Induced Hepatotoxicity in Rats: Involvment of Adiponectin and Tumor Necrosis Factor-α

elhameed¹,

Salama

Attia

et al. 2018

NIDOC-ASRT

View full text Add to dashboard Cite

“…There was significant reversal of biochemical (glutamic oxaloacetate transaminase, glutamic pyruvic transaminase, bilirubin), histological and functional changes (pentobarbitione sleeping time) induced by rifampicin in rats treated by petroleum ether extract [116]. The hepato-protective action of Ficus carica leaf ethanolic extract was evaluated in hepatotoxicity induced by carbon tetrachloride (CCl 4 ) in mice.…”

Section: Nephro-and Hepato-protective Effectmentioning

confidence: 99%

Nutritional and pharmacological importance of Ficus carica - A review

Al-Snafi¹

2017

IOSRPHR

126

111

View full text Add to dashboard Cite

Abstract:-The preliminary phytocemical analysis showed that the fruits of Ficus carica contained alkaloids, tannins, glycosides, flavanoids, saponins, coumarins, sterols, terpenes carbohydrates, phenols, essential oil, volatile oil, proteins and minerals. The previous pharmacological studies revealed that Ficus carica possessed antibacterial, antiviral, antiparasitic, antioxidant, anticancer, antimutagene, anti-angiogenic, antiinflammatory, antipyretic, antidiabetic, antiplatelet, reproductive, endocrine, immunological, dermatological, hypolipidemic, nootropic, antispasmodic, antidiarrheal, anti-warts, nephro-and hepato-protective effects. The current paper reviewed the chemical constituents, nutritional and pharmacological importance of Ficus carica.

show abstract

“…Other species of Ficus viz. F. carica (Gond & Khadabadi, 2008), F. glomerata (Kubsad et al, 2008), and F. racemosa (Mandal et al, 1999) were found to have hepatoprotective activity. Based on this, an attempt has been made to evaluate the hepatoprotective effect of F. benghalensis.…”

Section: Introductionmentioning

confidence: 99%

Protective role of Ficus benghalensis against isoniazid-rifampicin induced oxidative liver injury in rat

Parameswari¹,

Saleem²,

Chandrasekar³

et al. 2012

Rev. bras. farmacogn.

View full text Add to dashboard Cite

The present study was made to investigate the protective effect of methanolic extract of Ficus benghalensis L., Moraceae, on isoniazid-rifampicininduced hepatotoxicity in rats. Rats were divided into six different groups; group 1 served as a control, group 2 received isoniazid and rifampicin (100 mg/ kg, i.p.), in sterile water, groups 3, 4 and 5 received 100, 200 & 300 mg/kg bw, p.o. methanolic extract of F. benghalensis and group 6 received Liv 52. All the treatment protocols followed 21 days and after rats were sacrificed blood and liver were used for biochemical and histological studies, respectively. Administration of isoniazid and rifampicin caused a significant elevation in the levels of liver marker enzymes (p<0.05 and p<0.01) and thiobarbituric acid reactive substances (p<0.001) in experimental rats. Administration of methanolic extracts of F. benghalensis significantly prevented isoniazid-rifampicin-induced elevation in the levels of serum diagnostic liver marker enzymes and TBARS level in experimental groups of rats. Morever, total protein and reduced glutathione levels were significantly (p<0.001) increased in treatment group. The effect of extract was compared with a standard drug, Liv 52. The changes in biochemical parameters were supported by histological profile. It is to be concluded that the methanolic extract of F. benghalensis protects against isoniazid and rifampicin-induced oxidative liver injury in rats.

show abstract

Hepatoprotective activity of <i> Ficus carica</i> leaf extract on rifampicin-induced hepatic damage in rats

Cited by 78 publications

References 9 publications

Protective Effects of Moringa oleifera extract on Isoniazid and Rifampicin Induced Hepatotoxicity in Rats: Involvment of Adiponectin and Tumor Necrosis Factor-α

Protective Effects of Moringa oleifera extract on Isoniazid and Rifampicin Induced Hepatotoxicity in Rats: Involvment of Adiponectin and Tumor Necrosis Factor-α

Nutritional and pharmacological importance of Ficus carica - A review

Protective role of Ficus benghalensis against isoniazid-rifampicin induced oxidative liver injury in rat

Contact Info

Product

Resources

About